Effects of propranolol on bone metabolism in spontaneously hypertensive rats

The effects of propranolol (PRO), a nonselective beta-adrenergic receptor (beta-AR) antagonist with membrane-stabilizing action on bone metabolism, were examined in spontaneously hypertensive rats (SHR) showing osteoporosis with hyperactivity of the sympathetic nervous system. Treatment of SHR with...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2010-07, Vol.334 (1), p.99-105
Hauptverfasser:	Sato, Takuma, Arai, Michitsugu, Goto, Shigemi, Togari, Akifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-2 Receptor Antagonists Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Animals Blood Pressure - drug effects Bone Density - drug effects Bone Resorption - metabolism Bone Resorption - prevention & control Dose-Response Relationship, Drug Hypertension - drug therapy Hypertension - metabolism Lumbar Vertebrae - drug effects Lumbar Vertebrae - metabolism Male Propranolol - administration & dosage Propranolol - pharmacology Propranolol - therapeutic use Rats Rats, Inbred SHR Tibia - drug effects Tibia - metabolism
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