Ceramides and Barrier Function in Healthy Skin
Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and...
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| Veröffentlicht in: | Acta dermato-venereologica 2010-01, Vol.90 (4), p.350-353 |
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| container_title | Acta dermato-venereologica |
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| creator | MUTANU JUNGERSTED, Jakob HELLGREN, Lars I HØGH, Julie K DRACHMANN, Tue JEMEC, Gregor B. E AGNER, Tove |
| description | Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02). |
| doi_str_mv | 10.2340/00015555-0894 |
| format | Article |
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No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. 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No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Ceramides - metabolism</subject><subject>Cholesterol - metabolism</subject><subject>Denmark</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Permeability</subject><subject>Skin - metabolism</subject><subject>Skin Absorption</subject><subject>Surveys and Questionnaires</subject><subject>Water Loss, Insensible</subject><subject>Young Adult</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDFPwzAQhS0EoqUwsqIsiCnlHNtJPEJEKVIlBmC2nIsjDIlT7GTovydRW7jl9PQ-veEj5JrCMmEc7gGAivFiyCU_IXOaChonILJTMp-6eCpn5CKErzEmgubnZDb1XMh8TpaF8bq1lQmRdlX0qL23xkerwWFvOxdZF62NbvrPXfT2bd0lOat1E8zV4S_Ix-rpvVjHm9fnl-JhEyNLaR9LxmmOBpDLqgQUUNMamWSaoxgz6BqN5JkpoQJAiizLciyZYJqmCeWULcjdfnfru5_BhF61NqBpGu1MNwSVMcZACMlHMt6T6LsQvKnV1ttW-52ioCZD6mhITYZG_uawPJStqf7oo5IRuD0AOqBuaq8d2vDPMQCRjkO_i3xq9g</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>MUTANU JUNGERSTED, Jakob</creator><creator>HELLGREN, Lars I</creator><creator>HØGH, Julie K</creator><creator>DRACHMANN, Tue</creator><creator>JEMEC, Gregor B. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Ceramides - metabolism Cholesterol - metabolism Denmark Dermatology Female Humans Male Medical sciences Middle Aged Permeability Skin - metabolism Skin Absorption Surveys and Questionnaires Water Loss, Insensible Young Adult |
| title | Ceramides and Barrier Function in Healthy Skin |
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