Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension
Abstract Background Idiopathic pulmonary arterial hypertension (IPAH) is a disease characterized by progressively increased resistance of pulmonary arteries. In this study, we evaluated the mechanical property of single pulmonary artery smooth muscles cells (PASMC) from patients with IPAH and tested...
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| Veröffentlicht in: | International journal of cardiology 2010-04, Vol.140 (1), p.102-107 |
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| creator | Nakamura, Kazufumi Shimizu, Juichiro Kataoka, Noriyuki Hashimoto, Katsushi Ikeda, Tetsuya Fujio, Hideki Ohta-Ogo, Keiko Ogawa, Aiko Miura, Aya Mohri, Satoshi Nagase, Satoshi Morita, Hiroshi Kusano, Kengo Fukushima Date, Hiroshi Matsubara, Hiromi Mochizuki, Seiichi Hashimoto, Ken Kajiya, Fumihiko Ohe, Tohru |
| description | Abstract Background Idiopathic pulmonary arterial hypertension (IPAH) is a disease characterized by progressively increased resistance of pulmonary arteries. In this study, we evaluated the mechanical property of single pulmonary artery smooth muscles cells (PASMC) from patients with IPAH and tested whether the PASMC showed abnormal response to a vasodilator by use of an atomic force microscope (AFM). Methods PASMC were isolated and cultured from explanted lungs of 7 patients with IPAH (IPAH-PASMC). Normal vascular specimens from 3 patients with bronchogenic carcinoma were used as normal controls (normal PASMC). The nano/micro-order elasticity of five to ten living PASMC in each sample was measured by parabolic force curves of cantilever deflection/indentation obtained by using an AFM. The elasticity measurements were performed under control conditions and under condition of nitric oxide (NO) treatment (190 and 380 nmol/L). Results There was no significant difference between nano/micro-order elasticity of normal PASMC and that of IPAH-PASMC under the control conditions. In normal PASMC, NO (190 and 380 nmol/L) significantly reduced (i.e., softened) the nano/micro-order elasticity. However, NO did not reduce elasticity in IPAH-PASMC, indicating higher vasodilator-resistive nano/micro-order rigidity in IPAH-PASMC. Conclusion Nano/micro-order elasticity change in PASMC in response to vasodilation induced by NO is reduced in patients with IPAH. |
| doi_str_mv | 10.1016/j.ijcard.2008.11.022 |
| format | Article |
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In this study, we evaluated the mechanical property of single pulmonary artery smooth muscles cells (PASMC) from patients with IPAH and tested whether the PASMC showed abnormal response to a vasodilator by use of an atomic force microscope (AFM). Methods PASMC were isolated and cultured from explanted lungs of 7 patients with IPAH (IPAH-PASMC). Normal vascular specimens from 3 patients with bronchogenic carcinoma were used as normal controls (normal PASMC). The nano/micro-order elasticity of five to ten living PASMC in each sample was measured by parabolic force curves of cantilever deflection/indentation obtained by using an AFM. The elasticity measurements were performed under control conditions and under condition of nitric oxide (NO) treatment (190 and 380 nmol/L). Results There was no significant difference between nano/micro-order elasticity of normal PASMC and that of IPAH-PASMC under the control conditions. In normal PASMC, NO (190 and 380 nmol/L) significantly reduced (i.e., softened) the nano/micro-order elasticity. However, NO did not reduce elasticity in IPAH-PASMC, indicating higher vasodilator-resistive nano/micro-order rigidity in IPAH-PASMC. Conclusion Nano/micro-order elasticity change in PASMC in response to vasodilation induced by NO is reduced in patients with IPAH.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2008.11.022</identifier><identifier>PMID: 19073348</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; Atomic force microscope ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular ; Cells, Cultured ; Child ; Elasticity ; Female ; Free Radical Scavengers - pharmacology ; Humans ; Hypertension, Pulmonary - pathology ; Male ; Medical sciences ; Microscopy, Atomic Force ; Muscle Contraction - physiology ; Myocytes, Smooth Muscle - drug effects ; Myocytes, Smooth Muscle - pathology ; Nanostructures ; Nitric oxide ; Nitric Oxide - pharmacology ; Pneumology ; Pulmonary hypertension ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Smooth muscle cell ; Vasodilator ; Vasodilator Agents - pharmacology ; Young Adult</subject><ispartof>International journal of cardiology, 2010-04, Vol.140 (1), p.102-107</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2008 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2008 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-84f745e0cec46bbd0bafc6e5b9f65c868b316c65169fdd1160d6c2152b978db43</citedby><cites>FETCH-LOGICAL-c446t-84f745e0cec46bbd0bafc6e5b9f65c868b316c65169fdd1160d6c2152b978db43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167527308011613$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22565614$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19073348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura, Kazufumi</creatorcontrib><creatorcontrib>Shimizu, Juichiro</creatorcontrib><creatorcontrib>Kataoka, Noriyuki</creatorcontrib><creatorcontrib>Hashimoto, Katsushi</creatorcontrib><creatorcontrib>Ikeda, Tetsuya</creatorcontrib><creatorcontrib>Fujio, Hideki</creatorcontrib><creatorcontrib>Ohta-Ogo, Keiko</creatorcontrib><creatorcontrib>Ogawa, Aiko</creatorcontrib><creatorcontrib>Miura, Aya</creatorcontrib><creatorcontrib>Mohri, Satoshi</creatorcontrib><creatorcontrib>Nagase, Satoshi</creatorcontrib><creatorcontrib>Morita, Hiroshi</creatorcontrib><creatorcontrib>Kusano, Kengo Fukushima</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><creatorcontrib>Matsubara, Hiromi</creatorcontrib><creatorcontrib>Mochizuki, Seiichi</creatorcontrib><creatorcontrib>Hashimoto, Ken</creatorcontrib><creatorcontrib>Kajiya, Fumihiko</creatorcontrib><creatorcontrib>Ohe, Tohru</creatorcontrib><title>Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Abstract Background Idiopathic pulmonary arterial hypertension (IPAH) is a disease characterized by progressively increased resistance of pulmonary arteries. In this study, we evaluated the mechanical property of single pulmonary artery smooth muscles cells (PASMC) from patients with IPAH and tested whether the PASMC showed abnormal response to a vasodilator by use of an atomic force microscope (AFM). Methods PASMC were isolated and cultured from explanted lungs of 7 patients with IPAH (IPAH-PASMC). Normal vascular specimens from 3 patients with bronchogenic carcinoma were used as normal controls (normal PASMC). The nano/micro-order elasticity of five to ten living PASMC in each sample was measured by parabolic force curves of cantilever deflection/indentation obtained by using an AFM. The elasticity measurements were performed under control conditions and under condition of nitric oxide (NO) treatment (190 and 380 nmol/L). Results There was no significant difference between nano/micro-order elasticity of normal PASMC and that of IPAH-PASMC under the control conditions. In normal PASMC, NO (190 and 380 nmol/L) significantly reduced (i.e., softened) the nano/micro-order elasticity. However, NO did not reduce elasticity in IPAH-PASMC, indicating higher vasodilator-resistive nano/micro-order rigidity in IPAH-PASMC. Conclusion Nano/micro-order elasticity change in PASMC in response to vasodilation induced by NO is reduced in patients with IPAH.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Atomic force microscope</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cells, Cultured</subject><subject>Child</subject><subject>Elasticity</subject><subject>Female</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Atomic Force</subject><subject>Muscle Contraction - physiology</subject><subject>Myocytes, Smooth Muscle - drug effects</subject><subject>Myocytes, Smooth Muscle - pathology</subject><subject>Nanostructures</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - pharmacology</subject><subject>Pneumology</subject><subject>Pulmonary hypertension</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Smooth muscle cell</subject><subject>Vasodilator</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Young Adult</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1DAUhS1ERYfCGyDkDWKV1HYcJ9kgVRUUpEpdFNaWY99oHBx7sJOiPAGvjdMZgdRNV7Z8v_vjcy5C7ygpKaHiciztqFU0JSOkLSktCWMv0I62DS9oU_OXaJexpqhZU52j1ymNhBDede0rdE470lQVb3foz5WbIYLBXvlwOVkdQxGigYjBqTRbbecVhwEfFjcFr-KKVcwJK05TCPMeT0vSDrAG59Ijp2YLfk74t81Ra2zIL3urnxawyuH9eoB898kG_wadDcoleHs6L9CPL5-_X38tbu9uvl1f3RaaczEXLR8aXgPRoLnoe0N6NWgBdd8NotataPuKCi1qKrrBGEoFMUIzWrO-a1rT8-oCfTzWPcTwa4E0y8mmbXrlISxJZlkqQljVZJIfySxJShEGeYh2yh-QlMjNATnKowNyc0BSKrMDOe39qcHST2D-J50kz8CHE6CSVm6Iymub_nGM1aIWdJv005GDLMeDhSiTztJqMDaCnqUJ9rlJnhbQznqbe_6EFdIYluiz1JLKxCSR99u2bMtCWpKFo1X1Fzycvug</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Nakamura, Kazufumi</creator><creator>Shimizu, Juichiro</creator><creator>Kataoka, Noriyuki</creator><creator>Hashimoto, Katsushi</creator><creator>Ikeda, Tetsuya</creator><creator>Fujio, Hideki</creator><creator>Ohta-Ogo, Keiko</creator><creator>Ogawa, Aiko</creator><creator>Miura, Aya</creator><creator>Mohri, Satoshi</creator><creator>Nagase, Satoshi</creator><creator>Morita, Hiroshi</creator><creator>Kusano, Kengo Fukushima</creator><creator>Date, Hiroshi</creator><creator>Matsubara, Hiromi</creator><creator>Mochizuki, Seiichi</creator><creator>Hashimoto, Ken</creator><creator>Kajiya, Fumihiko</creator><creator>Ohe, Tohru</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100401</creationdate><title>Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension</title><author>Nakamura, Kazufumi ; Shimizu, Juichiro ; Kataoka, Noriyuki ; Hashimoto, Katsushi ; Ikeda, Tetsuya ; Fujio, Hideki ; Ohta-Ogo, Keiko ; Ogawa, Aiko ; Miura, Aya ; Mohri, Satoshi ; Nagase, Satoshi ; Morita, Hiroshi ; Kusano, Kengo Fukushima ; Date, Hiroshi ; Matsubara, Hiromi ; Mochizuki, Seiichi ; Hashimoto, Ken ; Kajiya, Fumihiko ; Ohe, Tohru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-84f745e0cec46bbd0bafc6e5b9f65c868b316c65169fdd1160d6c2152b978db43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Atomic force microscope</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cells, Cultured</topic><topic>Child</topic><topic>Elasticity</topic><topic>Female</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Atomic Force</topic><topic>Muscle Contraction - physiology</topic><topic>Myocytes, Smooth Muscle - drug effects</topic><topic>Myocytes, Smooth Muscle - pathology</topic><topic>Nanostructures</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - pharmacology</topic><topic>Pneumology</topic><topic>Pulmonary hypertension</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Smooth muscle cell</topic><topic>Vasodilator</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Kazufumi</creatorcontrib><creatorcontrib>Shimizu, Juichiro</creatorcontrib><creatorcontrib>Kataoka, Noriyuki</creatorcontrib><creatorcontrib>Hashimoto, Katsushi</creatorcontrib><creatorcontrib>Ikeda, Tetsuya</creatorcontrib><creatorcontrib>Fujio, Hideki</creatorcontrib><creatorcontrib>Ohta-Ogo, Keiko</creatorcontrib><creatorcontrib>Ogawa, Aiko</creatorcontrib><creatorcontrib>Miura, Aya</creatorcontrib><creatorcontrib>Mohri, Satoshi</creatorcontrib><creatorcontrib>Nagase, Satoshi</creatorcontrib><creatorcontrib>Morita, Hiroshi</creatorcontrib><creatorcontrib>Kusano, Kengo Fukushima</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><creatorcontrib>Matsubara, Hiromi</creatorcontrib><creatorcontrib>Mochizuki, Seiichi</creatorcontrib><creatorcontrib>Hashimoto, Ken</creatorcontrib><creatorcontrib>Kajiya, Fumihiko</creatorcontrib><creatorcontrib>Ohe, Tohru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Kazufumi</au><au>Shimizu, Juichiro</au><au>Kataoka, Noriyuki</au><au>Hashimoto, Katsushi</au><au>Ikeda, Tetsuya</au><au>Fujio, Hideki</au><au>Ohta-Ogo, Keiko</au><au>Ogawa, Aiko</au><au>Miura, Aya</au><au>Mohri, Satoshi</au><au>Nagase, Satoshi</au><au>Morita, Hiroshi</au><au>Kusano, Kengo Fukushima</au><au>Date, Hiroshi</au><au>Matsubara, Hiromi</au><au>Mochizuki, Seiichi</au><au>Hashimoto, Ken</au><au>Kajiya, Fumihiko</au><au>Ohe, Tohru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>140</volume><issue>1</issue><spage>102</spage><epage>107</epage><pages>102-107</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>Abstract Background Idiopathic pulmonary arterial hypertension (IPAH) is a disease characterized by progressively increased resistance of pulmonary arteries. In this study, we evaluated the mechanical property of single pulmonary artery smooth muscles cells (PASMC) from patients with IPAH and tested whether the PASMC showed abnormal response to a vasodilator by use of an atomic force microscope (AFM). Methods PASMC were isolated and cultured from explanted lungs of 7 patients with IPAH (IPAH-PASMC). Normal vascular specimens from 3 patients with bronchogenic carcinoma were used as normal controls (normal PASMC). The nano/micro-order elasticity of five to ten living PASMC in each sample was measured by parabolic force curves of cantilever deflection/indentation obtained by using an AFM. The elasticity measurements were performed under control conditions and under condition of nitric oxide (NO) treatment (190 and 380 nmol/L). Results There was no significant difference between nano/micro-order elasticity of normal PASMC and that of IPAH-PASMC under the control conditions. In normal PASMC, NO (190 and 380 nmol/L) significantly reduced (i.e., softened) the nano/micro-order elasticity. However, NO did not reduce elasticity in IPAH-PASMC, indicating higher vasodilator-resistive nano/micro-order rigidity in IPAH-PASMC. Conclusion Nano/micro-order elasticity change in PASMC in response to vasodilation induced by NO is reduced in patients with IPAH.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19073348</pmid><doi>10.1016/j.ijcard.2008.11.022</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Atomic force microscope Biological and medical sciences Cardiology. Vascular system Cardiovascular Cells, Cultured Child Elasticity Female Free Radical Scavengers - pharmacology Humans Hypertension, Pulmonary - pathology Male Medical sciences Microscopy, Atomic Force Muscle Contraction - physiology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - pathology Nanostructures Nitric oxide Nitric Oxide - pharmacology Pneumology Pulmonary hypertension Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Smooth muscle cell Vasodilator Vasodilator Agents - pharmacology Young Adult |
| title | Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension |
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