Improving the mouse model for studying the efficacy of voriconazole
Outbred ICR mice were rendered neutropenic, infected intravenously with Fusarium solani and treated orally with voriconazole. When given alone, voriconazole was not protective up to 40 mg/kg/day. When grapefruit juice was administered before infection, mice were protected by voriconazole. The mechan...
Gespeichert in:
| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2003-06, Vol.51 (6), p.1373-1376 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1376 |
|---|---|
| container_issue | 6 |
| container_start_page | 1373 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 51 |
| creator | Graybill, John R. Najvar, Laura K. Gonzalez, Gloria M. Hernandez, Steve Bocanegra, Rosie |
| description | Outbred ICR mice were rendered neutropenic, infected intravenously with Fusarium solani and treated orally with voriconazole. When given alone, voriconazole was not protective up to 40 mg/kg/day. When grapefruit juice was administered before infection, mice were protected by voriconazole. The mechanism may be inhibition of gut mucosal cytochrome enzymes that rapidly degrade voriconazole in the mouse. These murine studies support expansion of voriconazole therapy in other highly resistant systemic mycoses. |
| doi_str_mv | 10.1093/jac/dkg261 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73329974</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73329974</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-98eecdded47819607762064530fadc374bb7938c6399587e61a072885ff6925a3</originalsourceid><addsrcrecordid>eNqF0c9r2zAUB3BRNpo066V_wDCD9jBwqx-2nnQcabsGAoXSsbCLUGQpc2pbnWSXpn99FZK1sMsu0uF9ePo-PYROCD4nWLKLtTYX1cOKcnKAxqTgOKdYkg9ojBkucyhKNkJHMa4xxrzk4hCNCIWCMyjGaDprH4N_qrtV1v-2WeuHuD0r22TOhyz2Q7X5W7TO1UabTeZd9uRDbXynX3xjP6GPTjfRHu_vCfpxfXU_vcnnt99n02_z3DCAPpfCWlNVtipAEMkxAKeYp3TY6SqRYrkEyYThTMpSgOVEY6BClM5xSUvNJuhs1zcl_jPY2Ku2jsY2je5syq2AMSolFP-FRGwfAEjwyz9w7YfQpSEUJcBTPsES-rpDJvgYg3XqMdStDhtFsNouQKUFqN0CEv687zgsW1u90_2PJ3C6Bzoa3bigO1PHd1dIKjmhyeU7V8fePr_VdXhQHBiU6mbxS93xa_aT3S_UJXsF8FecCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217662083</pqid></control><display><type>article</type><title>Improving the mouse model for studying the efficacy of voriconazole</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Free Full-Text Journals in Chemistry</source><creator>Graybill, John R. ; Najvar, Laura K. ; Gonzalez, Gloria M. ; Hernandez, Steve ; Bocanegra, Rosie</creator><creatorcontrib>Graybill, John R. ; Najvar, Laura K. ; Gonzalez, Gloria M. ; Hernandez, Steve ; Bocanegra, Rosie</creatorcontrib><description>Outbred ICR mice were rendered neutropenic, infected intravenously with Fusarium solani and treated orally with voriconazole. When given alone, voriconazole was not protective up to 40 mg/kg/day. When grapefruit juice was administered before infection, mice were protected by voriconazole. The mechanism may be inhibition of gut mucosal cytochrome enzymes that rapidly degrade voriconazole in the mouse. These murine studies support expansion of voriconazole therapy in other highly resistant systemic mycoses.</description><identifier>ISSN: 0305-7453</identifier><identifier>ISSN: 1460-2091</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkg261</identifier><identifier>PMID: 12746374</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Beverages ; Biological and medical sciences ; Citrus paradisi ; Disease Models, Animal ; Fusarium - drug effects ; Fusarium - growth & development ; Fusarium solani ; grapefruit juice ; Kidney - drug effects ; Kidney - microbiology ; Medical sciences ; Mice ; Mice, Inbred ICR ; Mycoses - drug therapy ; Mycoses - microbiology ; Pharmacology. Drug treatments ; Pyrimidines - pharmacology ; Pyrimidines - therapeutic use ; Spleen - drug effects ; Spleen - microbiology ; Triazoles - pharmacology ; Triazoles - therapeutic use ; Voriconazole</subject><ispartof>Journal of antimicrobial chemotherapy, 2003-06, Vol.51 (6), p.1373-1376</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jun 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-98eecdded47819607762064530fadc374bb7938c6399587e61a072885ff6925a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14929612$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12746374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graybill, John R.</creatorcontrib><creatorcontrib>Najvar, Laura K.</creatorcontrib><creatorcontrib>Gonzalez, Gloria M.</creatorcontrib><creatorcontrib>Hernandez, Steve</creatorcontrib><creatorcontrib>Bocanegra, Rosie</creatorcontrib><title>Improving the mouse model for studying the efficacy of voriconazole</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J. Antimicrob. Chemother</addtitle><description>Outbred ICR mice were rendered neutropenic, infected intravenously with Fusarium solani and treated orally with voriconazole. When given alone, voriconazole was not protective up to 40 mg/kg/day. When grapefruit juice was administered before infection, mice were protected by voriconazole. The mechanism may be inhibition of gut mucosal cytochrome enzymes that rapidly degrade voriconazole in the mouse. These murine studies support expansion of voriconazole therapy in other highly resistant systemic mycoses.</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Beverages</subject><subject>Biological and medical sciences</subject><subject>Citrus paradisi</subject><subject>Disease Models, Animal</subject><subject>Fusarium - drug effects</subject><subject>Fusarium - growth & development</subject><subject>Fusarium solani</subject><subject>grapefruit juice</subject><subject>Kidney - drug effects</subject><subject>Kidney - microbiology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Mycoses - drug therapy</subject><subject>Mycoses - microbiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrimidines - pharmacology</subject><subject>Pyrimidines - therapeutic use</subject><subject>Spleen - drug effects</subject><subject>Spleen - microbiology</subject><subject>Triazoles - pharmacology</subject><subject>Triazoles - therapeutic use</subject><subject>Voriconazole</subject><issn>0305-7453</issn><issn>1460-2091</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9r2zAUB3BRNpo066V_wDCD9jBwqx-2nnQcabsGAoXSsbCLUGQpc2pbnWSXpn99FZK1sMsu0uF9ePo-PYROCD4nWLKLtTYX1cOKcnKAxqTgOKdYkg9ojBkucyhKNkJHMa4xxrzk4hCNCIWCMyjGaDprH4N_qrtV1v-2WeuHuD0r22TOhyz2Q7X5W7TO1UabTeZd9uRDbXynX3xjP6GPTjfRHu_vCfpxfXU_vcnnt99n02_z3DCAPpfCWlNVtipAEMkxAKeYp3TY6SqRYrkEyYThTMpSgOVEY6BClM5xSUvNJuhs1zcl_jPY2Ku2jsY2je5syq2AMSolFP-FRGwfAEjwyz9w7YfQpSEUJcBTPsES-rpDJvgYg3XqMdStDhtFsNouQKUFqN0CEv687zgsW1u90_2PJ3C6Bzoa3bigO1PHd1dIKjmhyeU7V8fePr_VdXhQHBiU6mbxS93xa_aT3S_UJXsF8FecCw</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Graybill, John R.</creator><creator>Najvar, Laura K.</creator><creator>Gonzalez, Gloria M.</creator><creator>Hernandez, Steve</creator><creator>Bocanegra, Rosie</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Improving the mouse model for studying the efficacy of voriconazole</title><author>Graybill, John R. ; Najvar, Laura K. ; Gonzalez, Gloria M. ; Hernandez, Steve ; Bocanegra, Rosie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-98eecdded47819607762064530fadc374bb7938c6399587e61a072885ff6925a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Beverages</topic><topic>Biological and medical sciences</topic><topic>Citrus paradisi</topic><topic>Disease Models, Animal</topic><topic>Fusarium - drug effects</topic><topic>Fusarium - growth & development</topic><topic>Fusarium solani</topic><topic>grapefruit juice</topic><topic>Kidney - drug effects</topic><topic>Kidney - microbiology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Mycoses - drug therapy</topic><topic>Mycoses - microbiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrimidines - pharmacology</topic><topic>Pyrimidines - therapeutic use</topic><topic>Spleen - drug effects</topic><topic>Spleen - microbiology</topic><topic>Triazoles - pharmacology</topic><topic>Triazoles - therapeutic use</topic><topic>Voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graybill, John R.</creatorcontrib><creatorcontrib>Najvar, Laura K.</creatorcontrib><creatorcontrib>Gonzalez, Gloria M.</creatorcontrib><creatorcontrib>Hernandez, Steve</creatorcontrib><creatorcontrib>Bocanegra, Rosie</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graybill, John R.</au><au>Najvar, Laura K.</au><au>Gonzalez, Gloria M.</au><au>Hernandez, Steve</au><au>Bocanegra, Rosie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improving the mouse model for studying the efficacy of voriconazole</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J. Antimicrob. Chemother</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>51</volume><issue>6</issue><spage>1373</spage><epage>1376</epage><pages>1373-1376</pages><issn>0305-7453</issn><issn>1460-2091</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Outbred ICR mice were rendered neutropenic, infected intravenously with Fusarium solani and treated orally with voriconazole. When given alone, voriconazole was not protective up to 40 mg/kg/day. When grapefruit juice was administered before infection, mice were protected by voriconazole. The mechanism may be inhibition of gut mucosal cytochrome enzymes that rapidly degrade voriconazole in the mouse. These murine studies support expansion of voriconazole therapy in other highly resistant systemic mycoses.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12746374</pmid><doi>10.1093/jac/dkg261</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 2003-06, Vol.51 (6), p.1373-1376 |
| issn | 0305-7453 1460-2091 1460-2091 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73329974 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Free Full-Text Journals in Chemistry |
| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Beverages Biological and medical sciences Citrus paradisi Disease Models, Animal Fusarium - drug effects Fusarium - growth & development Fusarium solani grapefruit juice Kidney - drug effects Kidney - microbiology Medical sciences Mice Mice, Inbred ICR Mycoses - drug therapy Mycoses - microbiology Pharmacology. Drug treatments Pyrimidines - pharmacology Pyrimidines - therapeutic use Spleen - drug effects Spleen - microbiology Triazoles - pharmacology Triazoles - therapeutic use Voriconazole |
| title | Improving the mouse model for studying the efficacy of voriconazole |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T14%3A01%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Improving%20the%20mouse%20model%20for%20studying%20the%20efficacy%20of%20voriconazole&rft.jtitle=Journal%20of%20antimicrobial%20chemotherapy&rft.au=Graybill,%20John%20R.&rft.date=2003-06-01&rft.volume=51&rft.issue=6&rft.spage=1373&rft.epage=1376&rft.pages=1373-1376&rft.issn=0305-7453&rft.eissn=1460-2091&rft.coden=JACHDX&rft_id=info:doi/10.1093/jac/dkg261&rft_dat=%3Cproquest_cross%3E73329974%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217662083&rft_id=info:pmid/12746374&rfr_iscdi=true |