Expression of Genes Associated with Bone Resorption is Increased and Bone Formation is Decreased in Mice Fed a High-Fat Diet

A high-fat diet (HFD) leads to an increased risk of osteoporosis-related fractures, but the molecular mechanisms for its effects on bone metabolism have rarely been addressed. The present study investigated the possible molecular mechanisms for the dyslipidemic HFD-induced bone loss through comparin...

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Veröffentlicht in:	Lipids 2010-04, Vol.45 (4), p.345-355
Hauptverfasser:	Xiao, Ying, Cui, Jue, Li, Ya-Xin, Shi, Yong-Hui, Le, Guo-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - anatomy & histology Adipose Tissue - drug effects Adiposity - drug effects Adiposity - genetics animal disease models Animal Feed Animals antioxidants Apolipoprotein E biomarkers Biomedical and Life Sciences Biosynthesis body weight Body Weight - drug effects Body Weight - genetics bone density Bone Density - drug effects Bone Density - genetics bone formation Bone mass Bone metabolism Bone resorption Bone Resorption - etiology Bone Resorption - genetics Bone turnover Diet Diet, Atherogenic Dietary Fats - pharmacology DNA microarrays Eating - drug effects Eating - physiology Fatty acids food intake Fractures Gene expression Gene expression profiles Gene Expression Profiling gene expression regulation Gene Expression Regulation - drug effects Genes - drug effects High fat diet human diseases human health Hyperlipidemia Insulin-like growth factor-binding protein 4 Interleukin 4 Life Sciences lipid metabolism Lipidology Male Medical Biochemistry Medicinal Chemistry Mice Mice, Inbred C57BL Microbial Genetics and Genomics Molecular modelling Neurochemistry Nutrition Oligonucleotide Array Sequence Analysis Original Article Osteogenesis Osteogenesis - drug effects Osteogenesis - genetics Osteoporosis p53 protein Peroxisome proliferator-activated receptors Polymerase chain reaction Risk assessment Signal transduction Transcription
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