Corneal Viscoelasticity Differences Between Diabetic and Nondiabetic Glaucomatous Patients
PURPOSETo investigate corneal viscoelasticity in primary open-angle glaucoma patients with and without diabetes mellitus, and to correlate corneal hysteresis (CH) with central corneal thickness (CCT). METHODSIn this cross-sectional study, 44 primary open-angle glaucoma patients [19 with diabetes (34...
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| Veröffentlicht in: | Journal of glaucoma 2010-06, Vol.19 (5), p.341-343 |
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| container_title | Journal of glaucoma |
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| creator | Castro, Dinorah Piacentini Engel Prata, Tiago Santos Lima, Verônica Castro Biteli, Luis Gustavo de Moraes, Carlos Gustavo Vasconcelos Paranhos, Augusto |
| description | PURPOSETo investigate corneal viscoelasticity in primary open-angle glaucoma patients with and without diabetes mellitus, and to correlate corneal hysteresis (CH) with central corneal thickness (CCT).
METHODSIn this cross-sectional study, 44 primary open-angle glaucoma patients [19 with diabetes (34 eyes) and 25 without diabetes (40 eyes)] underwent a complete ophthalmic examination. Data collected by masked investigators included CH and CCT using the Ocular Response Analyzer. The mean of 3 measurements was considered for each test. We analyzed the difference between the mean CH in both groups using a general linear model. Partial correlation coefficient between CH and CCT was also calculated.
RESULTSMean±SD age in diabetic and nondiabetic groups was 67.1±8.7 and 65.9±15.1, respectively (P=0.77). There was no significant difference regarding mean CCT between diabetic (531.7±31.3 μm) and nondiabetic (546.6±37.3 μm) groups (P=0.21). Patients with diabetes presented significantly higher CH values than patients without diabetes (9.1±1.9 mm Hg vs. 7.8±1.7 mm Hg, P=0.04). There was a significant and positive correlation between CH and CCT for all patients (r=0.407, P |
| doi_str_mv | 10.1097/IJG.0b013e3181b4caa1 |
| format | Article |
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METHODSIn this cross-sectional study, 44 primary open-angle glaucoma patients [19 with diabetes (34 eyes) and 25 without diabetes (40 eyes)] underwent a complete ophthalmic examination. Data collected by masked investigators included CH and CCT using the Ocular Response Analyzer. The mean of 3 measurements was considered for each test. We analyzed the difference between the mean CH in both groups using a general linear model. Partial correlation coefficient between CH and CCT was also calculated.
RESULTSMean±SD age in diabetic and nondiabetic groups was 67.1±8.7 and 65.9±15.1, respectively (P=0.77). There was no significant difference regarding mean CCT between diabetic (531.7±31.3 μm) and nondiabetic (546.6±37.3 μm) groups (P=0.21). Patients with diabetes presented significantly higher CH values than patients without diabetes (9.1±1.9 mm Hg vs. 7.8±1.7 mm Hg, P=0.04). There was a significant and positive correlation between CH and CCT for all patients (r=0.407, P<0.001).
CONCLUSIONSPrimary open-angle glaucoma patients with diabetes have significantly higher CH values than those without diabetes. CH and CCT results were positively correlated. These findings merit further investigation to assess the role of different CH values on glaucoma evaluation and susceptibility.</description><identifier>ISSN: 1057-0829</identifier><identifier>EISSN: 1536-481X</identifier><identifier>DOI: 10.1097/IJG.0b013e3181b4caa1</identifier><identifier>PMID: 19855300</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Aged ; Cornea - physiopathology ; Cross-Sectional Studies ; Diabetes Mellitus - physiopathology ; Dilatation, Pathologic ; Elasticity - physiology ; Female ; Glaucoma, Open-Angle - physiopathology ; Humans ; Intraocular Pressure - physiology ; Male ; Prospective Studies ; Tonometry, Ocular</subject><ispartof>Journal of glaucoma, 2010-06, Vol.19 (5), p.341-343</ispartof><rights>2010 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3551-312614ff6d9a12628b8e4b2bdbc21746f289d29381f0335ba0d9345d1170e3223</citedby><cites>FETCH-LOGICAL-c3551-312614ff6d9a12628b8e4b2bdbc21746f289d29381f0335ba0d9345d1170e3223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19855300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castro, Dinorah Piacentini Engel</creatorcontrib><creatorcontrib>Prata, Tiago Santos</creatorcontrib><creatorcontrib>Lima, Verônica Castro</creatorcontrib><creatorcontrib>Biteli, Luis Gustavo</creatorcontrib><creatorcontrib>de Moraes, Carlos Gustavo Vasconcelos</creatorcontrib><creatorcontrib>Paranhos, Augusto</creatorcontrib><title>Corneal Viscoelasticity Differences Between Diabetic and Nondiabetic Glaucomatous Patients</title><title>Journal of glaucoma</title><addtitle>J Glaucoma</addtitle><description>PURPOSETo investigate corneal viscoelasticity in primary open-angle glaucoma patients with and without diabetes mellitus, and to correlate corneal hysteresis (CH) with central corneal thickness (CCT).
METHODSIn this cross-sectional study, 44 primary open-angle glaucoma patients [19 with diabetes (34 eyes) and 25 without diabetes (40 eyes)] underwent a complete ophthalmic examination. Data collected by masked investigators included CH and CCT using the Ocular Response Analyzer. The mean of 3 measurements was considered for each test. We analyzed the difference between the mean CH in both groups using a general linear model. Partial correlation coefficient between CH and CCT was also calculated.
RESULTSMean±SD age in diabetic and nondiabetic groups was 67.1±8.7 and 65.9±15.1, respectively (P=0.77). There was no significant difference regarding mean CCT between diabetic (531.7±31.3 μm) and nondiabetic (546.6±37.3 μm) groups (P=0.21). Patients with diabetes presented significantly higher CH values than patients without diabetes (9.1±1.9 mm Hg vs. 7.8±1.7 mm Hg, P=0.04). There was a significant and positive correlation between CH and CCT for all patients (r=0.407, P<0.001).
CONCLUSIONSPrimary open-angle glaucoma patients with diabetes have significantly higher CH values than those without diabetes. CH and CCT results were positively correlated. These findings merit further investigation to assess the role of different CH values on glaucoma evaluation and susceptibility.</description><subject>Aged</subject><subject>Cornea - physiopathology</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Dilatation, Pathologic</subject><subject>Elasticity - physiology</subject><subject>Female</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Male</subject><subject>Prospective Studies</subject><subject>Tonometry, Ocular</subject><issn>1057-0829</issn><issn>1536-481X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAQhi0EoqXwBgjlxinFY8eNc4QCpagCDoAQl8iOJ2ogC9iOqr49Ri1C4sBptn-2j5BjoGOgWXo2v52NqabAkYMEnRRKwQ4ZguCTOJHwsht8KtKYSpYNyIFzb5QyyhjskwFkUghO6ZC8Tjvboqqj58oVHdbK-aqo_Dq6rMoSLbYFuugC_QqxDTmlMdQj1ZrormvNTzyrVV90jfJd76IH5StsvTske6WqHR5t7Yg8XV89Tm_ixf1sPj1fxAUXAmIObAJJWU5MpoLLpJaYaKaNLhikyaRkMjMs4xJKyrnQipqMJ8IApBQ5Y3xETjdzP2z32aPzeRN-wbpWLYZ78pRzlok0kBqRZKMsbOecxTL_sFWj7DoHmn9DzQPU_C_U0HayXdDrBs1v05ZiEMiNYNXVHq17r_sV2nwZuPrl_7O_AMIDhmI</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>Castro, Dinorah Piacentini Engel</creator><creator>Prata, Tiago Santos</creator><creator>Lima, Verônica Castro</creator><creator>Biteli, Luis Gustavo</creator><creator>de Moraes, Carlos Gustavo Vasconcelos</creator><creator>Paranhos, Augusto</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201006</creationdate><title>Corneal Viscoelasticity Differences Between Diabetic and Nondiabetic Glaucomatous Patients</title><author>Castro, Dinorah Piacentini Engel ; Prata, Tiago Santos ; Lima, Verônica Castro ; Biteli, Luis Gustavo ; de Moraes, Carlos Gustavo Vasconcelos ; Paranhos, Augusto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3551-312614ff6d9a12628b8e4b2bdbc21746f289d29381f0335ba0d9345d1170e3223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Cornea - physiopathology</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Dilatation, Pathologic</topic><topic>Elasticity - physiology</topic><topic>Female</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Male</topic><topic>Prospective Studies</topic><topic>Tonometry, Ocular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castro, Dinorah Piacentini Engel</creatorcontrib><creatorcontrib>Prata, Tiago Santos</creatorcontrib><creatorcontrib>Lima, Verônica Castro</creatorcontrib><creatorcontrib>Biteli, Luis Gustavo</creatorcontrib><creatorcontrib>de Moraes, Carlos Gustavo Vasconcelos</creatorcontrib><creatorcontrib>Paranhos, Augusto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of glaucoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castro, Dinorah Piacentini Engel</au><au>Prata, Tiago Santos</au><au>Lima, Verônica Castro</au><au>Biteli, Luis Gustavo</au><au>de Moraes, Carlos Gustavo Vasconcelos</au><au>Paranhos, Augusto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corneal Viscoelasticity Differences Between Diabetic and Nondiabetic Glaucomatous Patients</atitle><jtitle>Journal of glaucoma</jtitle><addtitle>J Glaucoma</addtitle><date>2010-06</date><risdate>2010</risdate><volume>19</volume><issue>5</issue><spage>341</spage><epage>343</epage><pages>341-343</pages><issn>1057-0829</issn><eissn>1536-481X</eissn><abstract>PURPOSETo investigate corneal viscoelasticity in primary open-angle glaucoma patients with and without diabetes mellitus, and to correlate corneal hysteresis (CH) with central corneal thickness (CCT).
METHODSIn this cross-sectional study, 44 primary open-angle glaucoma patients [19 with diabetes (34 eyes) and 25 without diabetes (40 eyes)] underwent a complete ophthalmic examination. Data collected by masked investigators included CH and CCT using the Ocular Response Analyzer. The mean of 3 measurements was considered for each test. We analyzed the difference between the mean CH in both groups using a general linear model. Partial correlation coefficient between CH and CCT was also calculated.
RESULTSMean±SD age in diabetic and nondiabetic groups was 67.1±8.7 and 65.9±15.1, respectively (P=0.77). There was no significant difference regarding mean CCT between diabetic (531.7±31.3 μm) and nondiabetic (546.6±37.3 μm) groups (P=0.21). Patients with diabetes presented significantly higher CH values than patients without diabetes (9.1±1.9 mm Hg vs. 7.8±1.7 mm Hg, P=0.04). There was a significant and positive correlation between CH and CCT for all patients (r=0.407, P<0.001).
CONCLUSIONSPrimary open-angle glaucoma patients with diabetes have significantly higher CH values than those without diabetes. CH and CCT results were positively correlated. These findings merit further investigation to assess the role of different CH values on glaucoma evaluation and susceptibility.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>19855300</pmid><doi>10.1097/IJG.0b013e3181b4caa1</doi><tpages>3</tpages></addata></record> |
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| subjects | Aged Cornea - physiopathology Cross-Sectional Studies Diabetes Mellitus - physiopathology Dilatation, Pathologic Elasticity - physiology Female Glaucoma, Open-Angle - physiopathology Humans Intraocular Pressure - physiology Male Prospective Studies Tonometry, Ocular |
| title | Corneal Viscoelasticity Differences Between Diabetic and Nondiabetic Glaucomatous Patients |
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