Primary Sclerosing Cholangitis and Extraintestinal Manifestations in Patients with Ulcerative Colitis and Ileal Pouch–Anal Anastomosis
Objective The aim of this study was to assess complications and functional outcomes in patients having ileal pouch–anal anastomosis for ulcerative colitis with or without primary sclerosing cholangitis or extraintestinal manifestations and to assess if primary sclerosing cholangitis is a risk factor...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2010-07, Vol.14 (7), p.1099-1104 |
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| creator | Wasmuth, Hans H. Tranø, Gerd Endreseth, Birger H. Wibe, Arne Rydning, Astrid Myrvold, Helge E. |
| description | Objective
The aim of this study was to assess complications and functional outcomes in patients having ileal pouch–anal anastomosis for ulcerative colitis with or without primary sclerosing cholangitis or extraintestinal manifestations and to assess if primary sclerosing cholangitis is a risk factor for pouchitis.
Materials and methods
From 1984 to 2007, 289 patients underwent proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis. Mean follow-up time was 12 years and data was recorded prospectively. Eleven patients had primary sclerosing cholangitis, six had pyoderma gangrenosum, and 12 had arthritis or ankylosing spondylitis.
Results
Early complications were similar for patients with or without extraintestinal manifestations. Functional outcomes were similar, but more incontinence among patients with sclerosing cholangitis was found. These patients had more frequent pouchitis, 5.25 vs. 2.72 average episodes of pouchitis (
p
= 0.048), and more chronic pouchitis, 4/11 vs. 17/260 (
p
|
| doi_str_mv | 10.1007/s11605-010-1223-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733295582</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2790405281</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-18b6da089a1b1c23de8fd0b107493a4bcb61878018964b77d1f3520f454533673</originalsourceid><addsrcrecordid>eNp1UU1v1DAQtRCIlsIP4IIsceAUmLHjfByrVSmVilgJKnGznMTZdZW1i-3A9saRO_-QX8KsUiqExMWesd978_EYe47wGgHqNwmxAlUAQoFCyGL_gB1jU8uirET1kGJosRBKfT5iT1K6BsAasHnMjgSUDQglj9mPdXQ7E2_5x36yMSTnN3y1DZPxG5dd4sYP_Gyfo3E-25SdNxN_b7wbKTHZBZ-483xNofU58W8ub_nV1NtIL18tX4XpXuZiskReh7nf_vr-8_SgREfKYUdl01P2aDRTss_u7hN29fbs0-pdcfnh_GJ1eln0ssZcYNNVg4GmNdhhL-Rgm3GADqEuW2nKru8q2kBDY7ZV2dX1gKNUAsZSlUrKqpYn7NWiexPDl5mm0DuXejvRxDbMSddSilapRhDy5T_I6zBHajtpRBQkVgESChdUT9tL0Y76ZtmoRtAHl_TikoZDTi7pPXFe3CnP3c4O94w_thBALIBEX35j41-l_6v6G4G7n4w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1112367601</pqid></control><display><type>article</type><title>Primary Sclerosing Cholangitis and Extraintestinal Manifestations in Patients with Ulcerative Colitis and Ileal Pouch–Anal Anastomosis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Wasmuth, Hans H. ; Tranø, Gerd ; Endreseth, Birger H. ; Wibe, Arne ; Rydning, Astrid ; Myrvold, Helge E.</creator><creatorcontrib>Wasmuth, Hans H. ; Tranø, Gerd ; Endreseth, Birger H. ; Wibe, Arne ; Rydning, Astrid ; Myrvold, Helge E.</creatorcontrib><description>Objective
The aim of this study was to assess complications and functional outcomes in patients having ileal pouch–anal anastomosis for ulcerative colitis with or without primary sclerosing cholangitis or extraintestinal manifestations and to assess if primary sclerosing cholangitis is a risk factor for pouchitis.
Materials and methods
From 1984 to 2007, 289 patients underwent proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis. Mean follow-up time was 12 years and data was recorded prospectively. Eleven patients had primary sclerosing cholangitis, six had pyoderma gangrenosum, and 12 had arthritis or ankylosing spondylitis.
Results
Early complications were similar for patients with or without extraintestinal manifestations. Functional outcomes were similar, but more incontinence among patients with sclerosing cholangitis was found. These patients had more frequent pouchitis, 5.25 vs. 2.72 average episodes of pouchitis (
p
= 0.048), and more chronic pouchitis, 4/11 vs. 17/260 (
p
< 0.001) compared to patients without adjunct disease. Neoplasm of the colon was more frequent in patients with primary sclerosing cholangitis, 4/11 vs. 4/260 in ulcerative colitis patients (
p
< 0.001).
Conclusion
An association between primary sclerosing cholangitis and chronic/severe pouchitis was found, but not with other extraintestinal manifestations. Functional results were good and alike in patients with and without primary sclerosing cholangitis. Primary sclerosing cholangitis is a risk factor for chronic pouchitis and is associated with neoplasia.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-010-1223-x</identifier><identifier>PMID: 20480253</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Arthritis - etiology ; Athletes ; Cancer ; Cholangitis, Sclerosing - complications ; Colitis, Ulcerative - surgery ; Colonic Neoplasms - etiology ; Female ; Gastroenterology ; Humans ; Inflammatory bowel disease ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Postoperative Complications ; Pouchitis - etiology ; Proctocolectomy, Restorative ; Pyoderma Gangrenosum - etiology ; Risk Management ; Spondylitis, Ankylosing - etiology ; Surgery ; Treatment Outcome</subject><ispartof>Journal of gastrointestinal surgery, 2010-07, Vol.14 (7), p.1099-1104</ispartof><rights>The Society for Surgery of the Alimentary Tract 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-18b6da089a1b1c23de8fd0b107493a4bcb61878018964b77d1f3520f454533673</citedby><cites>FETCH-LOGICAL-c371t-18b6da089a1b1c23de8fd0b107493a4bcb61878018964b77d1f3520f454533673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-010-1223-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-010-1223-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20480253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wasmuth, Hans H.</creatorcontrib><creatorcontrib>Tranø, Gerd</creatorcontrib><creatorcontrib>Endreseth, Birger H.</creatorcontrib><creatorcontrib>Wibe, Arne</creatorcontrib><creatorcontrib>Rydning, Astrid</creatorcontrib><creatorcontrib>Myrvold, Helge E.</creatorcontrib><title>Primary Sclerosing Cholangitis and Extraintestinal Manifestations in Patients with Ulcerative Colitis and Ileal Pouch–Anal Anastomosis</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Objective
The aim of this study was to assess complications and functional outcomes in patients having ileal pouch–anal anastomosis for ulcerative colitis with or without primary sclerosing cholangitis or extraintestinal manifestations and to assess if primary sclerosing cholangitis is a risk factor for pouchitis.
Materials and methods
From 1984 to 2007, 289 patients underwent proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis. Mean follow-up time was 12 years and data was recorded prospectively. Eleven patients had primary sclerosing cholangitis, six had pyoderma gangrenosum, and 12 had arthritis or ankylosing spondylitis.
Results
Early complications were similar for patients with or without extraintestinal manifestations. Functional outcomes were similar, but more incontinence among patients with sclerosing cholangitis was found. These patients had more frequent pouchitis, 5.25 vs. 2.72 average episodes of pouchitis (
p
= 0.048), and more chronic pouchitis, 4/11 vs. 17/260 (
p
< 0.001) compared to patients without adjunct disease. Neoplasm of the colon was more frequent in patients with primary sclerosing cholangitis, 4/11 vs. 4/260 in ulcerative colitis patients (
p
< 0.001).
Conclusion
An association between primary sclerosing cholangitis and chronic/severe pouchitis was found, but not with other extraintestinal manifestations. Functional results were good and alike in patients with and without primary sclerosing cholangitis. Primary sclerosing cholangitis is a risk factor for chronic pouchitis and is associated with neoplasia.</description><subject>Adult</subject><subject>Arthritis - etiology</subject><subject>Athletes</subject><subject>Cancer</subject><subject>Cholangitis, Sclerosing - complications</subject><subject>Colitis, Ulcerative - surgery</subject><subject>Colonic Neoplasms - etiology</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Postoperative Complications</subject><subject>Pouchitis - etiology</subject><subject>Proctocolectomy, Restorative</subject><subject>Pyoderma Gangrenosum - etiology</subject><subject>Risk Management</subject><subject>Spondylitis, Ankylosing - etiology</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1UU1v1DAQtRCIlsIP4IIsceAUmLHjfByrVSmVilgJKnGznMTZdZW1i-3A9saRO_-QX8KsUiqExMWesd978_EYe47wGgHqNwmxAlUAQoFCyGL_gB1jU8uirET1kGJosRBKfT5iT1K6BsAasHnMjgSUDQglj9mPdXQ7E2_5x36yMSTnN3y1DZPxG5dd4sYP_Gyfo3E-25SdNxN_b7wbKTHZBZ-483xNofU58W8ub_nV1NtIL18tX4XpXuZiskReh7nf_vr-8_SgREfKYUdl01P2aDRTss_u7hN29fbs0-pdcfnh_GJ1eln0ssZcYNNVg4GmNdhhL-Rgm3GADqEuW2nKru8q2kBDY7ZV2dX1gKNUAsZSlUrKqpYn7NWiexPDl5mm0DuXejvRxDbMSddSilapRhDy5T_I6zBHajtpRBQkVgESChdUT9tL0Y76ZtmoRtAHl_TikoZDTi7pPXFe3CnP3c4O94w_thBALIBEX35j41-l_6v6G4G7n4w</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Wasmuth, Hans H.</creator><creator>Tranø, Gerd</creator><creator>Endreseth, Birger H.</creator><creator>Wibe, Arne</creator><creator>Rydning, Astrid</creator><creator>Myrvold, Helge E.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100701</creationdate><title>Primary Sclerosing Cholangitis and Extraintestinal Manifestations in Patients with Ulcerative Colitis and Ileal Pouch–Anal Anastomosis</title><author>Wasmuth, Hans H. ; Tranø, Gerd ; Endreseth, Birger H. ; Wibe, Arne ; Rydning, Astrid ; Myrvold, Helge E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-18b6da089a1b1c23de8fd0b107493a4bcb61878018964b77d1f3520f454533673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Arthritis - etiology</topic><topic>Athletes</topic><topic>Cancer</topic><topic>Cholangitis, Sclerosing - complications</topic><topic>Colitis, Ulcerative - surgery</topic><topic>Colonic Neoplasms - etiology</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Postoperative Complications</topic><topic>Pouchitis - etiology</topic><topic>Proctocolectomy, Restorative</topic><topic>Pyoderma Gangrenosum - etiology</topic><topic>Risk Management</topic><topic>Spondylitis, Ankylosing - etiology</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wasmuth, Hans H.</creatorcontrib><creatorcontrib>Tranø, Gerd</creatorcontrib><creatorcontrib>Endreseth, Birger H.</creatorcontrib><creatorcontrib>Wibe, Arne</creatorcontrib><creatorcontrib>Rydning, Astrid</creatorcontrib><creatorcontrib>Myrvold, Helge E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wasmuth, Hans H.</au><au>Tranø, Gerd</au><au>Endreseth, Birger H.</au><au>Wibe, Arne</au><au>Rydning, Astrid</au><au>Myrvold, Helge E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary Sclerosing Cholangitis and Extraintestinal Manifestations in Patients with Ulcerative Colitis and Ileal Pouch–Anal Anastomosis</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>14</volume><issue>7</issue><spage>1099</spage><epage>1104</epage><pages>1099-1104</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Objective
The aim of this study was to assess complications and functional outcomes in patients having ileal pouch–anal anastomosis for ulcerative colitis with or without primary sclerosing cholangitis or extraintestinal manifestations and to assess if primary sclerosing cholangitis is a risk factor for pouchitis.
Materials and methods
From 1984 to 2007, 289 patients underwent proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis. Mean follow-up time was 12 years and data was recorded prospectively. Eleven patients had primary sclerosing cholangitis, six had pyoderma gangrenosum, and 12 had arthritis or ankylosing spondylitis.
Results
Early complications were similar for patients with or without extraintestinal manifestations. Functional outcomes were similar, but more incontinence among patients with sclerosing cholangitis was found. These patients had more frequent pouchitis, 5.25 vs. 2.72 average episodes of pouchitis (
p
= 0.048), and more chronic pouchitis, 4/11 vs. 17/260 (
p
< 0.001) compared to patients without adjunct disease. Neoplasm of the colon was more frequent in patients with primary sclerosing cholangitis, 4/11 vs. 4/260 in ulcerative colitis patients (
p
< 0.001).
Conclusion
An association between primary sclerosing cholangitis and chronic/severe pouchitis was found, but not with other extraintestinal manifestations. Functional results were good and alike in patients with and without primary sclerosing cholangitis. Primary sclerosing cholangitis is a risk factor for chronic pouchitis and is associated with neoplasia.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>20480253</pmid><doi>10.1007/s11605-010-1223-x</doi><tpages>6</tpages></addata></record> |
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| issn | 1091-255X 1873-4626 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Arthritis - etiology Athletes Cancer Cholangitis, Sclerosing - complications Colitis, Ulcerative - surgery Colonic Neoplasms - etiology Female Gastroenterology Humans Inflammatory bowel disease Male Medicine Medicine & Public Health Original Article Postoperative Complications Pouchitis - etiology Proctocolectomy, Restorative Pyoderma Gangrenosum - etiology Risk Management Spondylitis, Ankylosing - etiology Surgery Treatment Outcome |
| title | Primary Sclerosing Cholangitis and Extraintestinal Manifestations in Patients with Ulcerative Colitis and Ileal Pouch–Anal Anastomosis |
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