New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

Background & Aims During the process of liver fibrosis, hepatic stellate cells (HSCs) play a critical role in the excessive production of extracellular matrix (ECM). We evaluated the therapeutic effects of sorafenib, a multiple receptor tyrosine kinase inhibitor, targeting platelet-derived growt...

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Veröffentlicht in:	Journal of hepatology 2010-07, Vol.53 (1), p.132-144
Hauptverfasser:	Wang, Yan, Gao, Juncha, Zhang, Di, Zhang, Jian, Ma, Junji, Jiang, Huiqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Base Sequence Benzenesulfonates - pharmacology Biological and medical sciences Caspase 3 - metabolism Cell Cycle - drug effects Cell proliferation Cell Proliferation - drug effects Cells, Cultured Collagen Collagen Type I - biosynthesis Collagen Type I - genetics DNA Primers - genetics Down-Regulation - drug effects Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Hepatic stellate cell Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Humans In Vitro Techniques Liver Cirrhosis - drug therapy Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver fibrosis Liver. Biliary tract. Portal circulation. Exocrine pancreas Male MAP Kinase Signaling System - drug effects Medical sciences Niacinamide - analogs & derivatives Other diseases. Semiology Phenylurea Compounds Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Rats Rats, Sprague-Dawley Rats, Wistar Sorafenib
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