ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration

: Cell movement is generated by a driving force provided by dynamic cytoskeletal organization. Two main cytoskeletal‐dependent features, essential for migration, are the highly cell polarized structure and focal adhesion complexes. Cell migration and substrate anchorage are finely regulated by exte...

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Veröffentlicht in:	Journal of pineal research 2009-01, Vol.46 (1), p.15-21
Hauptverfasser:	Ortíz-López, Leonardo, Morales-Mulia, Sandra, Ramírez-Rodríguez, Gerardo, Benítez-King, Gloria
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Analysis of Variance Animals Biological and medical sciences Breast Neoplasms - enzymology Breast Neoplasms - pathology cancer Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects cytoskeleton Cytoskeleton - drug effects Cytoskeleton - physiology focal adhesions Fundamental and applied biological sciences. Psychology Humans MCF-7 cells melatonin Melatonin - pharmacology Microscopy, Fluorescence Microtubules - drug effects migration Pyridines - pharmacology Rats rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Rho-associated protein kinase Vertebrates: endocrinology Wound Healing - drug effects
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