Clonal Origin of Epithelial Ovarian Carcinoma: Analysis by Loss of Heterozygosity, p53 Mutation, and X-Chromosome Inactivation

Background: It has been suggested that multiple sites of epithelial ovarian carcinoma on the peritoneal surface reflect polyclonal disease arising from multiple primary tumors in the peritoneal mesothelium, rather than monoclonal disease spread by metastases from one primary ovarian cancer. Purpose:...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1992-12, Vol.84 (23), p.1793-1798
Hauptverfasser:	Jacobs, I. J., Kohler, M. F., Wiseman, R. W., Marks, J. R., Whitaker, R., Kerns, B. A. J., Humphrey, P., Berchuck, A., Ponder, B. A. J., Bast, R. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences Carcinoma - genetics Carcinoma - pathology Clone Cells - physiology DNA, Neoplasm - genetics Dosage Compensation, Genetic Female Female genital diseases Gene Expression Regulation, Neoplastic Genes, p53 - genetics Gynecology. Andrology. Obstetrics Heterozygote Humans Medical sciences Mutation Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Tumors
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