Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29

A series of analogs of Ac-CCK-7 [Ac-Tyr(SO3H)-Met28-Gly29-Trp-Met-Asp- Phe-NH2, (1)] were prepared in which the Met28-Gly29 dipeptide was replaced by omega-aminoalkanoic acids. Compounds were assessed in binding assays using homogenated rat pancreatic membranes and bovine striatum as the source of C...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-10, Vol.35 (21), p.3774-3783
Hauptverfasser:	Tilley, Jefferson W, Danho, Waleed, Shiuey, Shian Jan, Kulesha, Irina, Swistok, Joseph, Makofske, Raymond, Michalewsky, Joseph, Triscari, Joseph, Nelson, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cattle Chemistry Cholecystokinin - analogs & derivatives Cholecystokinin - pharmacology Corpus Striatum - drug effects Corpus Striatum - metabolism Dipeptides - chemistry Exact sciences and technology Feeding Behavior - drug effects Glycine - chemistry In Vitro Techniques Magnetic Resonance Spectroscopy Male Methionine - chemistry Molecular Sequence Data Organic chemistry Pancreas - drug effects Pancreas - metabolism Peptides Preparations and properties Protein Conformation Rats Rats, Sprague-Dawley Receptors, Cholecystokinin - drug effects Receptors, Cholecystokinin - metabolism
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