Targeting Multiple Chorismate-Utilizing Enzymes with a Single Inhibitor: Validation of a Three-Stage Design

Chorismate-utilizing enzymes are attractive antimicrobial drug targets due to their absence in humans and their central role in bacterial survival and virulence. The structural and mechanistic homology of a group of these inspired the goal of discovering inhibitors that target multiple enzymes. Prev...

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Veröffentlicht in:	Journal of medicinal chemistry 2010-05, Vol.53 (9), p.3718-3729
Hauptverfasser:	Ziebart, Kristin T, Dixon, Seth M, Avila, Belem, El-Badri, Mohamed H, Guggenheim, Kathryn G, Kurth, Mark J, Toney, Michael D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthranilate Synthase - antagonists & inhibitors Anti-Bacterial Agents - chemistry Carbon-Nitrogen Ligases - antagonists & inhibitors Catalytic Domain Chorismic Acid - metabolism Drug Delivery Systems Enzyme Inhibitors - chemistry Humans Intramolecular Transferases - antagonists & inhibitors Transaminases
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