The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia

The c-Jun NH(2)-terminal kinase (JNK) signaling cascade has been implicated in a wide range of diseases, including cancer. It is unclear how different JNK proteins contribute to human cancer. Here, we report that JNK2 is activated in more than 70% of human squamous cell carcinoma (SCC) samples and t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-04, Vol.70 (8), p.3080-3088
Hauptverfasser:	Ke, Hengning, Harris, Rebecca, Coloff, Jonathan L, Jin, Jane Y, Leshin, Benjamin, Miliani de Marval, Paula, Tao, Shiying, Rathmell, Jeffrey C, Hall, Russell P, Zhang, Jennifer Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopsy - methods Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 - metabolism DNA, Complementary - metabolism Gene Expression Regulation, Neoplastic Glycolysis Humans Mice Mice, SCID Mitogen-Activated Protein Kinase 9 - metabolism Mitogen-Activated Protein Kinase 9 - physiology Models, Biological ras Proteins - metabolism Signal Transduction Skin Neoplasms - enzymology
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