Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

Leukocyte function-associated antigen-1 (LFA-1), also known as CD11a/CD18 or αLβ2, belongs to the β2 integrin subfamily and is constitutively expressed on all leukocytes. The major ligands of LFA-1 include three intercellular adhesion molecules 1, 2, and 3 (ICAM 1, 2, and 3). The interactions betwee...

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Veröffentlicht in:	Journal of medicinal chemistry 2010-05, Vol.53 (9), p.3814-3830
Hauptverfasser:	Watterson, Scott H, Xiao, Zili, Dodd, Dharmpal S, Tortolani, David R, Vaccaro, Wayne, Potin, Dominique, Launay, Michele, Stetsko, Dawn K, Skala, Stacey, Davis, Patric M, Lee, Deborah, Yang, Xiaoxia, McIntyre, Kim W, Balimane, Praveen, Patel, Karishma, Yang, Zheng, Marathe, Punit, Kadiyala, Pathanjali, Tebben, Andrew J, Sheriff, Steven, Chang, ChiehYing Y, Ziemba, Theresa, Zhang, Huiping, Chen, Bang-Chi, DelMonte, Albert J, Aranibar, Nelly, McKinnon, Murray, Barrish, Joel C, Suchard, Suzanne J, Murali Dhar, T. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Hydantoins - pharmacokinetics Hydantoins - pharmacology Immunologic Factors - chemistry Lymphocyte Function-Associated Antigen-1 - chemistry Lymphocyte Function-Associated Antigen-1 - drug effects Lymphocyte Function-Associated Antigen-1 - immunology Nicotinic Acids - pharmacokinetics Nicotinic Acids - toxicity Structure-Activity Relationship
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