Mycoplasma arthritidis superantigen (MAM)-induced macrophage nitric oxide release is MHC class II restricted, interferongamma dependent, and toll-like receptor 4 independent

Mycoplasma arthritidis causes arthritis in rodents that resembles human rheumatoid arthritis. It produces a superantigen (MAM) that stimulates production of cytokines by making a bridge between lymphocyte T-cell receptor with the appropriate Vbeta chain, and H-2 1-Ealpha MHC class II molecules. Here...

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Veröffentlicht in:	Experimental cell research 2003-06, Vol.286 (2), p.345-354
Hauptverfasser:	Ribeiro-Dias, Fátima, Shio, Marina Tiemi, Timenetsky, Jorge, Oliane, Ana Paula Camilo, Metran, Camila Cardoso, Pessoa, Fábio Borges, Jancar, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Bacterial Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Cell Communication - immunology Cells, Cultured Disease Models, Animal Dose-Response Relationship, Drug Histocompatibility Antigens Class II - drug effects Histocompatibility Antigens Class II - metabolism Interferon-gamma - metabolism Interferon-gamma - pharmacology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocytes - immunology Lymphocytes - metabolism Macrophages - drug effects Macrophages - metabolism Male Membrane Glycoproteins - drug effects Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mitogens - pharmacology Nitric Oxide - biosynthesis Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - metabolism Proteins Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Signal Transduction - drug effects Signal Transduction - immunology Superantigens Toll-Like Receptor 4 Toll-Like Receptors
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