Tumoral angiogenesis and tissue factor expression during hepatocellular carcinoma progression in a transgenic mouse model

Background/Aims: The hypervascularity described in hepatocellular carcinoma varies according to the progression and the differentiation of the tumor, suggesting an angiogenic switch during tumor development. Methods: We used a transgenic mouse model of hepatocellular carcinoma induced by the express...

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Veröffentlicht in:	Journal of hepatology 2003-06, Vol.38 (6), p.793-802
Hauptverfasser:	Dupuy, Evelyne, Hainaud, Patricia, Villemain, Aude, Bodevin-Phèdre, Eva, Brouland, Jean Philippe, Briand, Pascale, Tobelem, Gérard
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Biological and medical sciences Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Disease Progression Female Gastroenterology. Liver. Pancreas. Abdomen Hepatocellular carcinoma HIF-1α Hypoxia-Inducible Factor 1, alpha Subunit Liver Neoplasms - blood supply Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mice Mice, Transgenic Neovascularization, Pathologic - blood Neovascularization, Pathologic - metabolism Platelet Activation RNA, Messenger - metabolism Thromboplastin - metabolism Tissue Distribution Tissue factor Transcription Factors - genetics Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vasculogenic mimicry
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