Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice

An insertion polymorphism of the angiotensin-I converting enzyme gene (ACE) is common in humans and the higher expressing allele is associated with an increased risk of diabetic complications. The ACE polymorphism does not significantly affect blood pressure or angiotensin II levels, suggesting that...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-06, Vol.107 (22), p.10190-10195
Hauptverfasser:	Kakoki, Masao, Sullivan, Kelli A, Backus, Carey, Hayes, John M, Oh, Sang Su, Hua, Kunjie, Gasim, Adil M.H, Tomita, Hirofumi, Grant, Ruriko, Nossov, Sarah B, Kim, Hyung-Suk, Jennette, J. Charles, Feldman, Eva L, Smithies, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitors Animals Biological Sciences Blood plasma Bone Density Bradykinin receptors Diabetes Diabetes complications Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetic nephropathies Diabetic Nephropathies - etiology Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic neuropathies Diabetic Neuropathies - etiology Diabetic Neuropathies - genetics Diabetic Neuropathies - metabolism Diabetic Neuropathies - physiopathology Diabetic neuropathy DNA, Mitochondrial - genetics Gene expression Genetic mutation Genotype & phenotype Humans Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Osteoporosis - etiology Osteoporosis - genetics Osteoporosis - metabolism Peptides Phenotype Polymorphism Receptor, Bradykinin B1 - deficiency Receptor, Bradykinin B1 - genetics Receptor, Bradykinin B2 - deficiency Receptor, Bradykinin B2 - genetics Receptors Rodents Type 1 diabetes mellitus Type 2 diabetes mellitus
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