Epistatic effects occurring among susceptibility and protective MHC genes in IgA deficiency

Immunoglobulin A deficiency (IgAD), the most prevalent primary immunodeficiency in Caucasian populations, shows strong evidence of polygenic inheritance with several associated genes being located in the major histocompatibility complex (MHC). Our aims were to determine which previously described MH...

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Veröffentlicht in:	Genes and immunity 2003-06, Vol.4 (4), p.316-320
Hauptverfasser:	Martínez, A, Gual, L, Fernández-Arquero, M, Nogales, A, Ferreira, A, Garcia-Rodriguez, M C, Fontan, G, Concha, EG de la
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Chi-Square Distribution Confidence Intervals Diseases Drb1 protein Epistasis Epistasis, Genetic Fundamental and applied biological sciences. Psychology Gene Expression Gene Frequency - genetics Genes, MHC Class II Genetic Predisposition to Disease Genotype Haplotypes Haplotypes - genetics Histocompatibility antigen HLA HLA-D Antigens - genetics Human Genetics Humans IgA Deficiency - genetics Immunodeficiency Immunoglobulin A Immunology Major histocompatibility complex Microbiology Multifactorial diseases Odds Ratio Polygenic inheritance Primary immunodeficiencies Susceptibility
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