Transcript Elongation by RNA Polymerase II
Until recently, it was generally assumed that essentially all regulation of transcription takes place via regions adjacent to the coding region of a gene--namely promoters and enhancers--and that, after recruitment to the promoter, the polymerase simply behaves like a machine, quickly "reading...
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| Veröffentlicht in: | Annual review of biochemistry 2010-01, Vol.79 (1), p.271-293 |
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| container_title | Annual review of biochemistry |
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| creator | Selth, Luke A Sigurdsson, Stefan Svejstrup, Jesper Q |
| description | Until recently, it was generally assumed that essentially all regulation of transcription takes place via regions adjacent to the coding region of a gene--namely promoters and enhancers--and that, after recruitment to the promoter, the polymerase simply behaves like a machine, quickly "reading the gene." However, over the past decade a revolution in this thinking has occurred, culminating in the idea that transcript elongation is extremely complex and highly regulated and, moreover, that this process significantly affects both the organization and integrity of the genome. This review addresses basic aspects of transcript elongation by RNA polymerase II (RNAPII) and how it relates to other DNA-related processes. |
| doi_str_mv | 10.1146/annurev.biochem.78.062807.091425 |
| format | Article |
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This review addresses basic aspects of transcript elongation by RNA polymerase II (RNAPII) and how it relates to other DNA-related processes.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Chromatin Assembly and Disassembly</subject><subject>Chromosomal Proteins, Non-Histone - metabolism</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Genetics</subject><subject>Humans</subject><subject>RNA polymerase</subject><subject>RNA Polymerase II - metabolism</subject><subject>Transcription, Genetic</subject><issn>0066-4154</issn><issn>1545-4509</issn><issn>1545-4509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1Lw0AQQBdRbK3-BQleFCFx9jt7s5SqhaIi9bxsko2m5KPuJkL_vdFED54Ghseb4SF0hSHCmIkbU9eds59RUjTpu60iGUcgSAwyAoUZ4QdoijnjIeOgDtEUQIiQ9ZsJOvF-CwBUMXKMJgSokEDxFF1vnKl96opdGyzLpn4zbdHUQbIPXh7nwXNT7ivrjLfBanWKjnJTens2zhl6vVtuFg_h-ul-tZivQ8OZbEOZ2iymPE5ynhAOlsgkV3mWMSk5JEZQlQshCCjJMhJjCyBJrqQFRdMU05zO0OXg3bnmo7O-1VXhU1uWprZN57WklAgilerJi3_ktulc3T-nOchYYfoD3Q5Q6hrvnc31zhWVcXuNQX9X1WNVPVbVMtZDVT1U7RXn450uqWz2J_jNSL8Asvx2Tw</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Selth, Luke A</creator><creator>Sigurdsson, Stefan</creator><creator>Svejstrup, Jesper Q</creator><general>Annual Reviews, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Transcript Elongation by RNA Polymerase II</title><author>Selth, Luke A ; 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| ispartof | Annual review of biochemistry, 2010-01, Vol.79 (1), p.271-293 |
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| source | Annual Reviews; MEDLINE |
| subjects | Animals Biochemistry Chromatin Assembly and Disassembly Chromosomal Proteins, Non-Histone - metabolism Deoxyribonucleic acid DNA Gene expression Gene Expression Regulation Genetics Humans RNA polymerase RNA Polymerase II - metabolism Transcription, Genetic |
| title | Transcript Elongation by RNA Polymerase II |
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