Enzyme promiscuity: a mechanistic and evolutionary perspective
Many, if not most, enzymes can promiscuously catalyze reactions, or act on substrates, other than those for which they evolved. Here, we discuss the structural, mechanistic, and evolutionary implications of this manifestation of infidelity of molecular recognition. We define promiscuity and related...
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| Veröffentlicht in: | Annual review of biochemistry 2010-01, Vol.79 (1), p.471-505 |
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| container_title | Annual review of biochemistry |
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| creator | Khersonsky, Olga Tawfik, Dan S |
| description | Many, if not most, enzymes can promiscuously catalyze reactions, or act on substrates, other than those for which they evolved. Here, we discuss the structural, mechanistic, and evolutionary implications of this manifestation of infidelity of molecular recognition. We define promiscuity and related phenomena and also address their generality and physiological implications. We discuss the mechanistic enzymology of promiscuity--how enzymes, which generally exert exquisite specificity, catalyze other, and sometimes barely related, reactions. Finally, we address the hypothesis that promiscuous enzymatic activities serve as evolutionary starting points and highlight the unique evolutionary features of promiscuous enzyme functions. |
| doi_str_mv | 10.1146/annurev-biochem-030409-143718 |
| format | Article |
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| ispartof | Annual review of biochemistry, 2010-01, Vol.79 (1), p.471-505 |
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| language | eng |
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| source | Annual Reviews; MEDLINE |
| subjects | Biochemistry Catalysis Catalytic Domain Enzymatic activity Enzymes Enzymes - chemistry Enzymes - genetics Enzymes - metabolism Evolution Evolution, Molecular Humans Molecules Substrate Specificity |
| title | Enzyme promiscuity: a mechanistic and evolutionary perspective |
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