Virus entry by endocytosis
Although viruses are simple in structure and composition, their interactions with host cells are complex. Merely to gain entry, animal viruses make use of a repertoire of cellular processes that involve hundreds of cellular proteins. Although some viruses have the capacity to penetrate into the cyto...
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| Veröffentlicht in: | Annual review of biochemistry 2010-01, Vol.79 (1), p.803-833 |
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| container_title | Annual review of biochemistry |
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| creator | Mercer, Jason Schelhaas, Mario Helenius, Ari |
| description | Although viruses are simple in structure and composition, their interactions with host cells are complex. Merely to gain entry, animal viruses make use of a repertoire of cellular processes that involve hundreds of cellular proteins. Although some viruses have the capacity to penetrate into the cytosol directly through the plasma membrane, most depend on endocytic uptake, vesicular transport through the cytoplasm, and delivery to endosomes and other intracellular organelles. The internalization may involve clathrin-mediated endocytosis (CME), macropinocytosis, caveolar/lipid raft-mediated endocytosis, or a variety of other still poorly characterized mechanisms. This review focuses on the cell biology of virus entry and the different strategies and endocytic mechanisms used by animal viruses. |
| doi_str_mv | 10.1146/annurev-biochem-060208-104626 |
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| ispartof | Annual review of biochemistry, 2010-01, Vol.79 (1), p.803-833 |
| issn | 0066-4154 1545-4509 |
| language | eng |
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| source | Annual Reviews; MEDLINE |
| subjects | Animals Biochemistry Caveolae - metabolism Cells Cellular biology Clathrin - metabolism Endocytosis Lipids Membrane Microdomains - metabolism Phagocytosis Pinocytosis Proteins Virus Internalization Viruses |
| title | Virus entry by endocytosis |
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