Biological variation in Trichinella species and genotypes
At present, the genus Trichinella comprises seven species of which five have encapsulated muscle larvae (T. spiralis, T. nativa, T. britovi, T. nelsoni and T. murrelli) and two do not (T. pseudospiralis and T. papuae) plus three genotypes of non-specific status (T6, T8 and T9). The diagnostic charac...
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| Veröffentlicht in: | Journal of helminthology 2003-06, Vol.77 (2), p.111-118 |
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| creator | Bolas-Fernández, F. |
| description | At present, the genus Trichinella comprises seven species of which five have encapsulated muscle larvae (T. spiralis, T. nativa, T. britovi, T. nelsoni and T. murrelli) and two do not (T. pseudospiralis and T. papuae) plus three genotypes of non-specific status (T6, T8 and T9). The diagnostic characteristics of these species are based on biological, biochemical and genetic criteria. Of biological significance is variation observed among species and isolates in parameters such as infectivity and immunogenicity. Infectivity of Trichinella species or isolates is determined, among other considerations, by the immune status of the host in response to species- or isolate-specific antigens. Common and particular antigens determine the extent of protective responses against homologous or heterologous challenge. The kinetics of isotype, cytokine and inflammatory responses against T. spiralis infections are isolate-dependent. Trichinella spiralis and T. pseudospiralis induce different dose-dependent T-cell polarizations in the early host response, with T. spiralis initially preferentially promoting Th1-type responses before switching to Th2 and T. pseudospiralis driving Th2-type responses from the outset. |
| doi_str_mv | 10.1079/JOH2003170 |
| format | Article |
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The diagnostic characteristics of these species are based on biological, biochemical and genetic criteria. Of biological significance is variation observed among species and isolates in parameters such as infectivity and immunogenicity. Infectivity of Trichinella species or isolates is determined, among other considerations, by the immune status of the host in response to species- or isolate-specific antigens. Common and particular antigens determine the extent of protective responses against homologous or heterologous challenge. The kinetics of isotype, cytokine and inflammatory responses against T. spiralis infections are isolate-dependent. Trichinella spiralis and T. pseudospiralis induce different dose-dependent T-cell polarizations in the early host response, with T. spiralis initially preferentially promoting Th1-type responses before switching to Th2 and T. pseudospiralis driving Th2-type responses from the outset.</description><identifier>ISSN: 0022-149X</identifier><identifier>EISSN: 1475-2697</identifier><identifier>DOI: 10.1079/JOH2003170</identifier><identifier>PMID: 12756064</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animals ; Antigens, Helminth - immunology ; Genotype ; Host-Parasite Interactions ; Intestinal Diseases, Parasitic - immunology ; Mice ; Mice, Inbred Strains ; Species Specificity ; Th1 Cells - immunology ; Th2 Cells - immunology ; Trichinella - genetics ; Trichinella - physiology ; Trichinellosis - immunology ; Trichinellosis - parasitology</subject><ispartof>Journal of helminthology, 2003-06, Vol.77 (2), p.111-118</ispartof><rights>Cambridge University Press 2003</rights><rights>Cambridge University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-f94d695636a016976208ec360a3b74c078fc7be97e1e74b6f5f4bffe8cb5228b3</citedby><cites>FETCH-LOGICAL-c385t-f94d695636a016976208ec360a3b74c078fc7be97e1e74b6f5f4bffe8cb5228b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022149X03000209/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,781,785,27929,27930,55633</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12756064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bolas-Fernández, F.</creatorcontrib><title>Biological variation in Trichinella species and genotypes</title><title>Journal of helminthology</title><addtitle>J. Helminthol</addtitle><description>At present, the genus Trichinella comprises seven species of which five have encapsulated muscle larvae (T. spiralis, T. nativa, T. britovi, T. nelsoni and T. murrelli) and two do not (T. pseudospiralis and T. papuae) plus three genotypes of non-specific status (T6, T8 and T9). The diagnostic characteristics of these species are based on biological, biochemical and genetic criteria. Of biological significance is variation observed among species and isolates in parameters such as infectivity and immunogenicity. Infectivity of Trichinella species or isolates is determined, among other considerations, by the immune status of the host in response to species- or isolate-specific antigens. Common and particular antigens determine the extent of protective responses against homologous or heterologous challenge. The kinetics of isotype, cytokine and inflammatory responses against T. spiralis infections are isolate-dependent. Trichinella spiralis and T. pseudospiralis induce different dose-dependent T-cell polarizations in the early host response, with T. spiralis initially preferentially promoting Th1-type responses before switching to Th2 and T. pseudospiralis driving Th2-type responses from the outset.</description><subject>Animals</subject><subject>Antigens, Helminth - immunology</subject><subject>Genotype</subject><subject>Host-Parasite Interactions</subject><subject>Intestinal Diseases, Parasitic - immunology</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Species Specificity</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><subject>Trichinella - genetics</subject><subject>Trichinella - physiology</subject><subject>Trichinellosis - immunology</subject><subject>Trichinellosis - parasitology</subject><issn>0022-149X</issn><issn>1475-2697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpt0E9LwzAYBvAgipvTix9AigcPYjV_2qQ9uk03ZTAGU7yFNH07o11bk1bct7dzw4F4yiE_3ufhQeiU4GuCRXzzOB1TjBkReA91SSBCn_JY7KMuxpT6JIhfOujIuTe8RjQ8RB1CRcgxD7oo7psyLxdGq9z7VNao2pSFZwpvbo1-NQXkufJcBdqA81SRegsoynpVgTtGB5nKHZxs3x56ur-bD8b-ZDp6GNxOfM2isPazOEh5HHLGFSZtLU5xBJpxrFgiAo1FlGmRQCyAgAgSnoVZkGQZRDoJKY0S1kMXm7uVLT8acLVcGqfXvQooGycFY5TjKGrh-R_4Vja2aLtJSljQRv-gyw3StnTOQiYra5bKriTBcr2m3K3Z4rPtxSZZQrqj2_la4G-AcTV8_f4r-y65YCKUfDSTQzIbjvrDSD63_mqbrpaJNekCdh3_yf8GgiuK3g</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Bolas-Fernández, F.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7SN</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H95</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Biological variation in Trichinella species and genotypes</title><author>Bolas-Fernández, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-f94d695636a016976208ec360a3b74c078fc7be97e1e74b6f5f4bffe8cb5228b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antigens, Helminth - immunology</topic><topic>Genotype</topic><topic>Host-Parasite Interactions</topic><topic>Intestinal Diseases, Parasitic - immunology</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Species Specificity</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><topic>Trichinella - genetics</topic><topic>Trichinella - physiology</topic><topic>Trichinellosis - immunology</topic><topic>Trichinellosis - parasitology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bolas-Fernández, F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Ecology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of helminthology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bolas-Fernández, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological variation in Trichinella species and genotypes</atitle><jtitle>Journal of helminthology</jtitle><addtitle>J. Helminthol</addtitle><date>2003-06</date><risdate>2003</risdate><volume>77</volume><issue>2</issue><spage>111</spage><epage>118</epage><pages>111-118</pages><issn>0022-149X</issn><eissn>1475-2697</eissn><abstract>At present, the genus Trichinella comprises seven species of which five have encapsulated muscle larvae (T. spiralis, T. nativa, T. britovi, T. nelsoni and T. murrelli) and two do not (T. pseudospiralis and T. papuae) plus three genotypes of non-specific status (T6, T8 and T9). The diagnostic characteristics of these species are based on biological, biochemical and genetic criteria. Of biological significance is variation observed among species and isolates in parameters such as infectivity and immunogenicity. Infectivity of Trichinella species or isolates is determined, among other considerations, by the immune status of the host in response to species- or isolate-specific antigens. Common and particular antigens determine the extent of protective responses against homologous or heterologous challenge. The kinetics of isotype, cytokine and inflammatory responses against T. spiralis infections are isolate-dependent. Trichinella spiralis and T. pseudospiralis induce different dose-dependent T-cell polarizations in the early host response, with T. spiralis initially preferentially promoting Th1-type responses before switching to Th2 and T. pseudospiralis driving Th2-type responses from the outset.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>12756064</pmid><doi>10.1079/JOH2003170</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Antigens, Helminth - immunology Genotype Host-Parasite Interactions Intestinal Diseases, Parasitic - immunology Mice Mice, Inbred Strains Species Specificity Th1 Cells - immunology Th2 Cells - immunology Trichinella - genetics Trichinella - physiology Trichinellosis - immunology Trichinellosis - parasitology |
| title | Biological variation in Trichinella species and genotypes |
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