Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities
Unusual expression of interleukin-1alpha, -1beta and -6 was previously found in the epiphyseal cartilage of rat fetuses prenatally exposed to various non-steroidal anti-inflammatory drugs (NSAID, i.e., ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitor (DFU). The aim of the pre...
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| Veröffentlicht in: | Folia histochemica et cytobiologica 2010-01, Vol.48 (1), p.30-36 |
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| creator | Burdan, Franciszek Szumilo, Justyna Korobowicz-Markiewicz, Agnieszka Dyndor, Katarzyna Szumilo, Michal Klepacz, Robert |
| description | Unusual expression of interleukin-1alpha, -1beta and -6 was previously found in the epiphyseal cartilage of rat fetuses prenatally exposed to various non-steroidal anti-inflammatory drugs (NSAID, i.e., ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitor (DFU). The aim of the present study was to evaluate the role of placenta in such phenomenon. Morphology of the organ, thickness of basal and labyrinth layer, immunoexpression of COX isoenzymes were examined, and confronted with maternal biochemical data and fetal developmental parameters. Higher maternal urea level, as well as lower placental weight and labyrinth thickness were found in the group of fetuses who revealed expression of genes coded the selected interleukins, when compared with the xenobiotic-exposed pups without the selected genes expression and untreated control. A significant correlation between placental weight and maternal total protein or urea level was revealed. Histological changes like inflammatory infiltration and calcification were observed sporadically. Location and intensity of COX-1 staining was similar in all cases. However, more intense COX-2 staining for majority of cells of the basal zone and in dispersed giant cells of the labyrinth was found in inflamed organs. It could be concluded that abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level. |
| doi_str_mv | 10.2478/v10042-008-0097-1 |
| format | Article |
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The aim of the present study was to evaluate the role of placenta in such phenomenon. Morphology of the organ, thickness of basal and labyrinth layer, immunoexpression of COX isoenzymes were examined, and confronted with maternal biochemical data and fetal developmental parameters. Higher maternal urea level, as well as lower placental weight and labyrinth thickness were found in the group of fetuses who revealed expression of genes coded the selected interleukins, when compared with the xenobiotic-exposed pups without the selected genes expression and untreated control. A significant correlation between placental weight and maternal total protein or urea level was revealed. Histological changes like inflammatory infiltration and calcification were observed sporadically. Location and intensity of COX-1 staining was similar in all cases. However, more intense COX-2 staining for majority of cells of the basal zone and in dispersed giant cells of the labyrinth was found in inflamed organs. It could be concluded that abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level.</description><identifier>ISSN: 0239-8508</identifier><identifier>EISSN: 1897-5631</identifier><identifier>DOI: 10.2478/v10042-008-0097-1</identifier><identifier>PMID: 20529813</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Abnormalities ; Animals ; Anti-inflammatory agents ; Calcification ; Cartilage ; Cartilage - enzymology ; Cartilage - metabolism ; Cartilage - pathology ; COX-2 inhibitors ; Cyclooxygenase 1 - metabolism ; Cyclooxygenase 2 - metabolism ; Cyclooxygenase-1 ; Cyclooxygenase-2 ; Cytokines ; Female ; Fetus - metabolism ; Fetus - pathology ; Fetuses ; Gene expression ; Gene Expression Regulation, Developmental ; Genes ; Giant cells ; Ibuprofen ; Immunohistochemistry ; Inflammation ; Interleukin 1 ; Interleukin-1 - genetics ; Interleukin-1 - metabolism ; Interleukin-6 - genetics ; Interleukin-6 - metabolism ; Isoenzymes ; Labyrinth ; Neutrophils - pathology ; Nonsteroidal anti-inflammatory drugs ; Organ Size ; Organs ; Piroxicam ; Placenta ; Placenta - abnormalities ; Placenta - enzymology ; Placenta - metabolism ; Placenta - pathology ; Pregnancy ; Rats ; Rats, Wistar ; Staining ; Thickness ; Tolmetin ; Urea</subject><ispartof>Folia histochemica et cytobiologica, 2010-01, Vol.48 (1), p.30-36</ispartof><rights>2010. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright Folia Histochemica et Cytobiologica 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-82f16475f1e2e0f2ba9d4c1d4d09f8aebd4024692360cac33f9b1e7830f157be3</citedby><cites>FETCH-LOGICAL-c355t-82f16475f1e2e0f2ba9d4c1d4d09f8aebd4024692360cac33f9b1e7830f157be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20529813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burdan, Franciszek</creatorcontrib><creatorcontrib>Szumilo, Justyna</creatorcontrib><creatorcontrib>Korobowicz-Markiewicz, Agnieszka</creatorcontrib><creatorcontrib>Dyndor, Katarzyna</creatorcontrib><creatorcontrib>Szumilo, Michal</creatorcontrib><creatorcontrib>Klepacz, Robert</creatorcontrib><title>Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities</title><title>Folia histochemica et cytobiologica</title><addtitle>Folia Histochem Cytobiol</addtitle><description>Unusual expression of interleukin-1alpha, -1beta and -6 was previously found in the epiphyseal cartilage of rat fetuses prenatally exposed to various non-steroidal anti-inflammatory drugs (NSAID, i.e., ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitor (DFU). The aim of the present study was to evaluate the role of placenta in such phenomenon. Morphology of the organ, thickness of basal and labyrinth layer, immunoexpression of COX isoenzymes were examined, and confronted with maternal biochemical data and fetal developmental parameters. Higher maternal urea level, as well as lower placental weight and labyrinth thickness were found in the group of fetuses who revealed expression of genes coded the selected interleukins, when compared with the xenobiotic-exposed pups without the selected genes expression and untreated control. A significant correlation between placental weight and maternal total protein or urea level was revealed. Histological changes like inflammatory infiltration and calcification were observed sporadically. Location and intensity of COX-1 staining was similar in all cases. However, more intense COX-2 staining for majority of cells of the basal zone and in dispersed giant cells of the labyrinth was found in inflamed organs. It could be concluded that abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level.</description><subject>Abnormalities</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Calcification</subject><subject>Cartilage</subject><subject>Cartilage - enzymology</subject><subject>Cartilage - metabolism</subject><subject>Cartilage - pathology</subject><subject>COX-2 inhibitors</subject><subject>Cyclooxygenase 1 - metabolism</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Cyclooxygenase-1</subject><subject>Cyclooxygenase-2</subject><subject>Cytokines</subject><subject>Female</subject><subject>Fetus - metabolism</subject><subject>Fetus - pathology</subject><subject>Fetuses</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes</subject><subject>Giant cells</subject><subject>Ibuprofen</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin-1 - genetics</subject><subject>Interleukin-1 - metabolism</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukin-6 - metabolism</subject><subject>Isoenzymes</subject><subject>Labyrinth</subject><subject>Neutrophils - pathology</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Organ Size</subject><subject>Organs</subject><subject>Piroxicam</subject><subject>Placenta</subject><subject>Placenta - abnormalities</subject><subject>Placenta - enzymology</subject><subject>Placenta - metabolism</subject><subject>Placenta - pathology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Staining</subject><subject>Thickness</subject><subject>Tolmetin</subject><subject>Urea</subject><issn>0239-8508</issn><issn>1897-5631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kU1v1DAQhi0EotvCD-BSWfTQU2DGH4lzRFWhlSpxoWfLccbgknUWO2nh3-PVlh4qcRjNSPPM6JUext4hfBCqMx_vEUCJBsDU6rsGX7ANmjroVuJLtgEh-8ZoMEfsuJQ7AN2CwtfsSIAWvUG5YXSb1rK6ice0UJ5o_RlTg9ylkTctp9-7TKXEOdU9D7RU0Lu8xMl9Jx4Ld6XMPrqFRv4Qlx98NzlPaY-5Ic1566a4RCpv2KvgpkJvH_sJu_18-e3iqrn5-uX64tNN46XWS2NEwFZ1OiAJgiAG14_K46hG6INxNIwKhGp7IVvwzksZ-gGpMxIC6m4gecLOD393ef61UlnsNhZP0-QSzWuxnZRC90qYSr5_Rt7Na041nNWi61AZpSt09j9I1BQGWsA9hQfK57mUTMHucty6_Mci2L0ne_Bkqye792Sx3pw-fl6HLY1PF__EyL9IR40-</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Burdan, Franciszek</creator><creator>Szumilo, Justyna</creator><creator>Korobowicz-Markiewicz, Agnieszka</creator><creator>Dyndor, Katarzyna</creator><creator>Szumilo, Michal</creator><creator>Klepacz, Robert</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities</title><author>Burdan, Franciszek ; Szumilo, Justyna ; Korobowicz-Markiewicz, Agnieszka ; Dyndor, Katarzyna ; Szumilo, Michal ; Klepacz, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-82f16475f1e2e0f2ba9d4c1d4d09f8aebd4024692360cac33f9b1e7830f157be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abnormalities</topic><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Calcification</topic><topic>Cartilage</topic><topic>Cartilage - enzymology</topic><topic>Cartilage - metabolism</topic><topic>Cartilage - pathology</topic><topic>COX-2 inhibitors</topic><topic>Cyclooxygenase 1 - metabolism</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Cyclooxygenase-1</topic><topic>Cyclooxygenase-2</topic><topic>Cytokines</topic><topic>Female</topic><topic>Fetus - metabolism</topic><topic>Fetus - pathology</topic><topic>Fetuses</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes</topic><topic>Giant cells</topic><topic>Ibuprofen</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Interleukin 1</topic><topic>Interleukin-1 - genetics</topic><topic>Interleukin-1 - metabolism</topic><topic>Interleukin-6 - genetics</topic><topic>Interleukin-6 - metabolism</topic><topic>Isoenzymes</topic><topic>Labyrinth</topic><topic>Neutrophils - pathology</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Organ Size</topic><topic>Organs</topic><topic>Piroxicam</topic><topic>Placenta</topic><topic>Placenta - 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Academic</collection><jtitle>Folia histochemica et cytobiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burdan, Franciszek</au><au>Szumilo, Justyna</au><au>Korobowicz-Markiewicz, Agnieszka</au><au>Dyndor, Katarzyna</au><au>Szumilo, Michal</au><au>Klepacz, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities</atitle><jtitle>Folia histochemica et cytobiologica</jtitle><addtitle>Folia Histochem Cytobiol</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>48</volume><issue>1</issue><spage>30</spage><epage>36</epage><pages>30-36</pages><issn>0239-8508</issn><eissn>1897-5631</eissn><abstract>Unusual expression of interleukin-1alpha, -1beta and -6 was previously found in the epiphyseal cartilage of rat fetuses prenatally exposed to various non-steroidal anti-inflammatory drugs (NSAID, i.e., ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitor (DFU). The aim of the present study was to evaluate the role of placenta in such phenomenon. Morphology of the organ, thickness of basal and labyrinth layer, immunoexpression of COX isoenzymes were examined, and confronted with maternal biochemical data and fetal developmental parameters. Higher maternal urea level, as well as lower placental weight and labyrinth thickness were found in the group of fetuses who revealed expression of genes coded the selected interleukins, when compared with the xenobiotic-exposed pups without the selected genes expression and untreated control. A significant correlation between placental weight and maternal total protein or urea level was revealed. Histological changes like inflammatory infiltration and calcification were observed sporadically. Location and intensity of COX-1 staining was similar in all cases. However, more intense COX-2 staining for majority of cells of the basal zone and in dispersed giant cells of the labyrinth was found in inflamed organs. It could be concluded that abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>20529813</pmid><doi>10.2478/v10042-008-0097-1</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Folia histochemica et cytobiologica, 2010-01, Vol.48 (1), p.30-36 |
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| subjects | Abnormalities Animals Anti-inflammatory agents Calcification Cartilage Cartilage - enzymology Cartilage - metabolism Cartilage - pathology COX-2 inhibitors Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase-1 Cyclooxygenase-2 Cytokines Female Fetus - metabolism Fetus - pathology Fetuses Gene expression Gene Expression Regulation, Developmental Genes Giant cells Ibuprofen Immunohistochemistry Inflammation Interleukin 1 Interleukin-1 - genetics Interleukin-1 - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Isoenzymes Labyrinth Neutrophils - pathology Nonsteroidal anti-inflammatory drugs Organ Size Organs Piroxicam Placenta Placenta - abnormalities Placenta - enzymology Placenta - metabolism Placenta - pathology Pregnancy Rats Rats, Wistar Staining Thickness Tolmetin Urea |
| title | Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities |
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