Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia
Background The aging population has resulted in more patients living with cardiovascular disease, such as atrial fibrillation (AF). Recent focus has been placed on understanding the long-term consequences of chronic cardiovascular disease, such as a potential increased risk of dementia. Objective Th...
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| Veröffentlicht in: | Heart rhythm 2010-04, Vol.7 (4), p.433-437 |
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| creator | Bunch, T. Jared, MD Weiss, J. Peter, MD Crandall, Brian G., MD May, Heidi T., PhD, MSPH Bair, Tami L., RN Osborn, Jeffrey S., MD Anderson, Jeffrey L., MD Muhlestein, Joseph B., MD Horne, Benjamin D., PhD, MSPH Lappe, Donald L., MD Day, John D., MD, FHRS |
| description | Background The aging population has resulted in more patients living with cardiovascular disease, such as atrial fibrillation (AF). Recent focus has been placed on understanding the long-term consequences of chronic cardiovascular disease, such as a potential increased risk of dementia. Objective This study sought to determine whether there is an association between AF and dementia and whether their coexistence is an independent marker of risk. Methods A total of 37,025 consecutive patients from the large ongoing prospective Intermountain Heart Collaborative Study database were evaluated and followed up for a mean of 5 years for the development of AF and dementia. Dementia was sub-typed into vascular (VD), senile (SD), Alzheimer's (AD), and nonspecified (ND). Results Of the 37,025 patients with a mean age of 60.6 ± 17.9 years, 10,161 (27%) developed AF and 1,535 (4.1%) developed dementia (179 VD, 321 SD, 347 AD, 688 ND) during the 5-year follow-up. Patients with dementia were older and had higher rates of hypertension, coronary artery disease, renal failure, heart failure, and prior strokes. In age-based analysis, AF independently was significantly associated with all dementia types. The highest risk was in the younger group ( |
| doi_str_mv | 10.1016/j.hrthm.2009.12.004 |
| format | Article |
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Jared, MD ; Weiss, J. Peter, MD ; Crandall, Brian G., MD ; May, Heidi T., PhD, MSPH ; Bair, Tami L., RN ; Osborn, Jeffrey S., MD ; Anderson, Jeffrey L., MD ; Muhlestein, Joseph B., MD ; Horne, Benjamin D., PhD, MSPH ; Lappe, Donald L., MD ; Day, John D., MD, FHRS</creator><creatorcontrib>Bunch, T. Jared, MD ; Weiss, J. Peter, MD ; Crandall, Brian G., MD ; May, Heidi T., PhD, MSPH ; Bair, Tami L., RN ; Osborn, Jeffrey S., MD ; Anderson, Jeffrey L., MD ; Muhlestein, Joseph B., MD ; Horne, Benjamin D., PhD, MSPH ; Lappe, Donald L., MD ; Day, John D., MD, FHRS</creatorcontrib><description>Background The aging population has resulted in more patients living with cardiovascular disease, such as atrial fibrillation (AF). Recent focus has been placed on understanding the long-term consequences of chronic cardiovascular disease, such as a potential increased risk of dementia. Objective This study sought to determine whether there is an association between AF and dementia and whether their coexistence is an independent marker of risk. Methods A total of 37,025 consecutive patients from the large ongoing prospective Intermountain Heart Collaborative Study database were evaluated and followed up for a mean of 5 years for the development of AF and dementia. Dementia was sub-typed into vascular (VD), senile (SD), Alzheimer's (AD), and nonspecified (ND). Results Of the 37,025 patients with a mean age of 60.6 ± 17.9 years, 10,161 (27%) developed AF and 1,535 (4.1%) developed dementia (179 VD, 321 SD, 347 AD, 688 ND) during the 5-year follow-up. Patients with dementia were older and had higher rates of hypertension, coronary artery disease, renal failure, heart failure, and prior strokes. In age-based analysis, AF independently was significantly associated with all dementia types. The highest risk was in the younger group (<70). After dementia diagnosis, the presence of AF was associated with a marked increased risk of mortality (VD: hazard ratio [HR] = 1.38, P = .01; SD: HR = 1.41, P = .001; AD: HR = 1.45; ND: HR = 1.38, P <.0001). Conclusion AF was independently associated with all forms of dementia. Although dementia is strongly associated with aging, the highest risk of AD was in the younger group, in support of the observed association. The presence of AF also identified dementia patients at high risk of death.</description><identifier>ISSN: 1547-5271</identifier><identifier>EISSN: 1556-3871</identifier><identifier>DOI: 10.1016/j.hrthm.2009.12.004</identifier><identifier>PMID: 20122875</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aging ; Alzheimer Disease - complications ; Alzheimer Disease - mortality ; Alzheimer's ; Atrial fibrillation ; Atrial Fibrillation - complications ; Atrial Fibrillation - mortality ; Cardiovascular ; Dementia ; Dementia, Vascular - complications ; Dementia, Vascular - mortality ; Female ; Humans ; Hypertension ; Male ; Middle Aged ; Risk Factors ; Stroke</subject><ispartof>Heart rhythm, 2010-04, Vol.7 (4), p.433-437</ispartof><rights>Heart Rhythm Society</rights><rights>2010 Heart Rhythm Society</rights><rights>Copyright 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-a3e8ed008f6aad51bda12f01b3c3e38bee13714929fa7997f2f59369e0b1fd803</citedby><cites>FETCH-LOGICAL-c458t-a3e8ed008f6aad51bda12f01b3c3e38bee13714929fa7997f2f59369e0b1fd803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.hrthm.2009.12.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20122875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bunch, T. Jared, MD</creatorcontrib><creatorcontrib>Weiss, J. Peter, MD</creatorcontrib><creatorcontrib>Crandall, Brian G., MD</creatorcontrib><creatorcontrib>May, Heidi T., PhD, MSPH</creatorcontrib><creatorcontrib>Bair, Tami L., RN</creatorcontrib><creatorcontrib>Osborn, Jeffrey S., MD</creatorcontrib><creatorcontrib>Anderson, Jeffrey L., MD</creatorcontrib><creatorcontrib>Muhlestein, Joseph B., MD</creatorcontrib><creatorcontrib>Horne, Benjamin D., PhD, MSPH</creatorcontrib><creatorcontrib>Lappe, Donald L., MD</creatorcontrib><creatorcontrib>Day, John D., MD, FHRS</creatorcontrib><title>Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia</title><title>Heart rhythm</title><addtitle>Heart Rhythm</addtitle><description>Background The aging population has resulted in more patients living with cardiovascular disease, such as atrial fibrillation (AF). Recent focus has been placed on understanding the long-term consequences of chronic cardiovascular disease, such as a potential increased risk of dementia. Objective This study sought to determine whether there is an association between AF and dementia and whether their coexistence is an independent marker of risk. Methods A total of 37,025 consecutive patients from the large ongoing prospective Intermountain Heart Collaborative Study database were evaluated and followed up for a mean of 5 years for the development of AF and dementia. Dementia was sub-typed into vascular (VD), senile (SD), Alzheimer's (AD), and nonspecified (ND). Results Of the 37,025 patients with a mean age of 60.6 ± 17.9 years, 10,161 (27%) developed AF and 1,535 (4.1%) developed dementia (179 VD, 321 SD, 347 AD, 688 ND) during the 5-year follow-up. Patients with dementia were older and had higher rates of hypertension, coronary artery disease, renal failure, heart failure, and prior strokes. In age-based analysis, AF independently was significantly associated with all dementia types. The highest risk was in the younger group (<70). After dementia diagnosis, the presence of AF was associated with a marked increased risk of mortality (VD: hazard ratio [HR] = 1.38, P = .01; SD: HR = 1.41, P = .001; AD: HR = 1.45; ND: HR = 1.38, P <.0001). Conclusion AF was independently associated with all forms of dementia. Although dementia is strongly associated with aging, the highest risk of AD was in the younger group, in support of the observed association. The presence of AF also identified dementia patients at high risk of death.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - mortality</subject><subject>Alzheimer's</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - mortality</subject><subject>Cardiovascular</subject><subject>Dementia</subject><subject>Dementia, Vascular - complications</subject><subject>Dementia, Vascular - mortality</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Stroke</subject><issn>1547-5271</issn><issn>1556-3871</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERUvhFyAh33ppgj_iJD6AtKqAIlXqoXC2HHuincVJFjtptfz6OmzLgQuX8RzeZ6x5hpB3nJWc8frDrtzGeTuUgjFdclEyVr0gZ1ypupBtw1-ufdUUSjT8lLxOaceY0DWTr8ipYFyItlFnxGzmiDbQHruIIdgZp5Fiojh62EMu4xwO1KY0ObQzePqA85YmGDHAJb23yS3BxktqR0834fcWcIB4kaiHIaNo35CT3oYEb5_ec_Ljy-fvV9fFze3Xb1ebm8JVqp0LK6EFz1jb19Z6xTtvuegZ76STINsOgMuGV1ro3jZaN73olZa1Btbx3rdMnpOL49x9nH4tkGYzYHKQNxphWpJppBSqrmSVk_KYdHFKKUJv9hEHGw-GM7OKNTvzR6xZxRouTBabqfdP85duAP-XeTaZAx-PAchb3iNEkxzC6MBjBDcbP-F_Pvj0D-8Cjuhs-AkHSLtpiWMWaLhJGTB3623X0zLNshrVyEd5u6C8</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Bunch, T. Jared, MD</creator><creator>Weiss, J. Peter, MD</creator><creator>Crandall, Brian G., MD</creator><creator>May, Heidi T., PhD, MSPH</creator><creator>Bair, Tami L., RN</creator><creator>Osborn, Jeffrey S., MD</creator><creator>Anderson, Jeffrey L., MD</creator><creator>Muhlestein, Joseph B., MD</creator><creator>Horne, Benjamin D., PhD, MSPH</creator><creator>Lappe, Donald L., MD</creator><creator>Day, John D., MD, FHRS</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100401</creationdate><title>Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia</title><author>Bunch, T. Jared, MD ; Weiss, J. Peter, MD ; Crandall, Brian G., MD ; May, Heidi T., PhD, MSPH ; Bair, Tami L., RN ; Osborn, Jeffrey S., MD ; Anderson, Jeffrey L., MD ; Muhlestein, Joseph B., MD ; Horne, Benjamin D., PhD, MSPH ; Lappe, Donald L., MD ; Day, John D., MD, FHRS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-a3e8ed008f6aad51bda12f01b3c3e38bee13714929fa7997f2f59369e0b1fd803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - mortality</topic><topic>Alzheimer's</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - mortality</topic><topic>Cardiovascular</topic><topic>Dementia</topic><topic>Dementia, Vascular - complications</topic><topic>Dementia, Vascular - mortality</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bunch, T. Jared, MD</creatorcontrib><creatorcontrib>Weiss, J. Peter, MD</creatorcontrib><creatorcontrib>Crandall, Brian G., MD</creatorcontrib><creatorcontrib>May, Heidi T., PhD, MSPH</creatorcontrib><creatorcontrib>Bair, Tami L., RN</creatorcontrib><creatorcontrib>Osborn, Jeffrey S., MD</creatorcontrib><creatorcontrib>Anderson, Jeffrey L., MD</creatorcontrib><creatorcontrib>Muhlestein, Joseph B., MD</creatorcontrib><creatorcontrib>Horne, Benjamin D., PhD, MSPH</creatorcontrib><creatorcontrib>Lappe, Donald L., MD</creatorcontrib><creatorcontrib>Day, John D., MD, FHRS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart rhythm</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bunch, T. Jared, MD</au><au>Weiss, J. Peter, MD</au><au>Crandall, Brian G., MD</au><au>May, Heidi T., PhD, MSPH</au><au>Bair, Tami L., RN</au><au>Osborn, Jeffrey S., MD</au><au>Anderson, Jeffrey L., MD</au><au>Muhlestein, Joseph B., MD</au><au>Horne, Benjamin D., PhD, MSPH</au><au>Lappe, Donald L., MD</au><au>Day, John D., MD, FHRS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia</atitle><jtitle>Heart rhythm</jtitle><addtitle>Heart Rhythm</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>7</volume><issue>4</issue><spage>433</spage><epage>437</epage><pages>433-437</pages><issn>1547-5271</issn><eissn>1556-3871</eissn><abstract>Background The aging population has resulted in more patients living with cardiovascular disease, such as atrial fibrillation (AF). Recent focus has been placed on understanding the long-term consequences of chronic cardiovascular disease, such as a potential increased risk of dementia. Objective This study sought to determine whether there is an association between AF and dementia and whether their coexistence is an independent marker of risk. Methods A total of 37,025 consecutive patients from the large ongoing prospective Intermountain Heart Collaborative Study database were evaluated and followed up for a mean of 5 years for the development of AF and dementia. Dementia was sub-typed into vascular (VD), senile (SD), Alzheimer's (AD), and nonspecified (ND). Results Of the 37,025 patients with a mean age of 60.6 ± 17.9 years, 10,161 (27%) developed AF and 1,535 (4.1%) developed dementia (179 VD, 321 SD, 347 AD, 688 ND) during the 5-year follow-up. Patients with dementia were older and had higher rates of hypertension, coronary artery disease, renal failure, heart failure, and prior strokes. In age-based analysis, AF independently was significantly associated with all dementia types. The highest risk was in the younger group (<70). After dementia diagnosis, the presence of AF was associated with a marked increased risk of mortality (VD: hazard ratio [HR] = 1.38, P = .01; SD: HR = 1.41, P = .001; AD: HR = 1.45; ND: HR = 1.38, P <.0001). Conclusion AF was independently associated with all forms of dementia. Although dementia is strongly associated with aging, the highest risk of AD was in the younger group, in support of the observed association. The presence of AF also identified dementia patients at high risk of death.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20122875</pmid><doi>10.1016/j.hrthm.2009.12.004</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aging Alzheimer Disease - complications Alzheimer Disease - mortality Alzheimer's Atrial fibrillation Atrial Fibrillation - complications Atrial Fibrillation - mortality Cardiovascular Dementia Dementia, Vascular - complications Dementia, Vascular - mortality Female Humans Hypertension Male Middle Aged Risk Factors Stroke |
| title | Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia |
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