Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis
Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2(3)) design was employed. The independent variables were polymer molecula...
Gespeichert in:
| Veröffentlicht in: | Drug delivery 2010-04, Vol.17 (3), p.178-186 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 186 |
|---|---|
| container_issue | 3 |
| container_start_page | 178 |
| container_title | Drug delivery |
| container_volume | 17 |
| creator | Sarisözen, Can Arica, Betül Orman, Mehmet N Hincal, A Atilla Caliş, Sema |
| description | Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2(3)) design was employed. The independent variables were polymer molecular weight, polymer concentration, and theoretical drug loading. Responses were the particle size, percentage of encapsulation efficiency, and the t(50%) release. The best formulation was prepared with 20% of PA and 1% of chitosan with medium molecular weight showing relative good yield of production (48.0 + or - 6.7%) and encapsulation efficiency (45.7 + or - 0.3%), and released the drug at a constant rate in 11 days. |
| doi_str_mv | 10.3109/10717541003667780 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_733255860</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733255860</sourcerecordid><originalsourceid>FETCH-LOGICAL-p125t-70ffec8d1d1642b8f5ee21dcdbbb71fdae54b3b1da82c80489a3aa1eedd1f53f3</originalsourceid><addsrcrecordid>eNo1kLtOwzAYhS0kREvhAViQN2AI-BLH7ogqblKlLjBHTvy7NUrsYDtI5elJRZnO8p2LDkJXlNxzSpYPlEgqRUkJ4VUlpSInaE4FowUpq3KGzlP6JIQoysQZmjFCl5UkYo72myG73v3o7ILHweIhgvEuhS54wLqFrDMUXdAGDG53LoekPe5dG0MadhAh4TE5v8Uas1t-h61uc4hOd9hAcluPbYiHzG_w-YBNhgw-JJcu0KnVXYLLoy7Qx_PT--q1WG9e3laP62KYtuZCEmuhVYYaWpWsUVYAMGpa0zSNpNZoEGXDG2q0Yq0ipVpqrjUFMIZawS1foJu_3CGGr3Gqr3uXWug67SGMqZacMyFURSby-kiOTQ-mHqLrddzX_2_xX0YVbl4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733255860</pqid></control><display><type>article</type><title>Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Sarisözen, Can ; Arica, Betül ; Orman, Mehmet N ; Hincal, A Atilla ; Caliş, Sema</creator><creatorcontrib>Sarisözen, Can ; Arica, Betül ; Orman, Mehmet N ; Hincal, A Atilla ; Caliş, Sema</creatorcontrib><description>Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2(3)) design was employed. The independent variables were polymer molecular weight, polymer concentration, and theoretical drug loading. Responses were the particle size, percentage of encapsulation efficiency, and the t(50%) release. The best formulation was prepared with 20% of PA and 1% of chitosan with medium molecular weight showing relative good yield of production (48.0 + or - 6.7%) and encapsulation efficiency (45.7 + or - 0.3%), and released the drug at a constant rate in 11 days.</description><identifier>EISSN: 1521-0464</identifier><identifier>DOI: 10.3109/10717541003667780</identifier><identifier>PMID: 20196705</identifier><language>eng</language><publisher>England</publisher><subject>Arteries - physiology ; Calorimetry, Differential Scanning ; Chitosan - chemistry ; Desiccation ; Drug Compounding ; Graft Occlusion, Vascular - prevention & control ; Hyperplasia - prevention & control ; Microscopy, Electron, Scanning ; Microspheres ; Particle Size ; Prednisolone - administration & dosage ; Prednisolone - analogs & derivatives ; Prednisolone - therapeutic use ; Prodrugs - administration & dosage ; Prodrugs - therapeutic use ; Solubility ; Stents</subject><ispartof>Drug delivery, 2010-04, Vol.17 (3), p.178-186</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20196705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarisözen, Can</creatorcontrib><creatorcontrib>Arica, Betül</creatorcontrib><creatorcontrib>Orman, Mehmet N</creatorcontrib><creatorcontrib>Hincal, A Atilla</creatorcontrib><creatorcontrib>Caliş, Sema</creatorcontrib><title>Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis</title><title>Drug delivery</title><addtitle>Drug Deliv</addtitle><description>Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2(3)) design was employed. The independent variables were polymer molecular weight, polymer concentration, and theoretical drug loading. Responses were the particle size, percentage of encapsulation efficiency, and the t(50%) release. The best formulation was prepared with 20% of PA and 1% of chitosan with medium molecular weight showing relative good yield of production (48.0 + or - 6.7%) and encapsulation efficiency (45.7 + or - 0.3%), and released the drug at a constant rate in 11 days.</description><subject>Arteries - physiology</subject><subject>Calorimetry, Differential Scanning</subject><subject>Chitosan - chemistry</subject><subject>Desiccation</subject><subject>Drug Compounding</subject><subject>Graft Occlusion, Vascular - prevention & control</subject><subject>Hyperplasia - prevention & control</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microspheres</subject><subject>Particle Size</subject><subject>Prednisolone - administration & dosage</subject><subject>Prednisolone - analogs & derivatives</subject><subject>Prednisolone - therapeutic use</subject><subject>Prodrugs - administration & dosage</subject><subject>Prodrugs - therapeutic use</subject><subject>Solubility</subject><subject>Stents</subject><issn>1521-0464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kLtOwzAYhS0kREvhAViQN2AI-BLH7ogqblKlLjBHTvy7NUrsYDtI5elJRZnO8p2LDkJXlNxzSpYPlEgqRUkJ4VUlpSInaE4FowUpq3KGzlP6JIQoysQZmjFCl5UkYo72myG73v3o7ILHweIhgvEuhS54wLqFrDMUXdAGDG53LoekPe5dG0MadhAh4TE5v8Uas1t-h61uc4hOd9hAcluPbYiHzG_w-YBNhgw-JJcu0KnVXYLLoy7Qx_PT--q1WG9e3laP62KYtuZCEmuhVYYaWpWsUVYAMGpa0zSNpNZoEGXDG2q0Yq0ipVpqrjUFMIZawS1foJu_3CGGr3Gqr3uXWug67SGMqZacMyFURSby-kiOTQ-mHqLrddzX_2_xX0YVbl4</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Sarisözen, Can</creator><creator>Arica, Betül</creator><creator>Orman, Mehmet N</creator><creator>Hincal, A Atilla</creator><creator>Caliş, Sema</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201004</creationdate><title>Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis</title><author>Sarisözen, Can ; Arica, Betül ; Orman, Mehmet N ; Hincal, A Atilla ; Caliş, Sema</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p125t-70ffec8d1d1642b8f5ee21dcdbbb71fdae54b3b1da82c80489a3aa1eedd1f53f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Arteries - physiology</topic><topic>Calorimetry, Differential Scanning</topic><topic>Chitosan - chemistry</topic><topic>Desiccation</topic><topic>Drug Compounding</topic><topic>Graft Occlusion, Vascular - prevention & control</topic><topic>Hyperplasia - prevention & control</topic><topic>Microscopy, Electron, Scanning</topic><topic>Microspheres</topic><topic>Particle Size</topic><topic>Prednisolone - administration & dosage</topic><topic>Prednisolone - analogs & derivatives</topic><topic>Prednisolone - therapeutic use</topic><topic>Prodrugs - administration & dosage</topic><topic>Prodrugs - therapeutic use</topic><topic>Solubility</topic><topic>Stents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarisözen, Can</creatorcontrib><creatorcontrib>Arica, Betül</creatorcontrib><creatorcontrib>Orman, Mehmet N</creatorcontrib><creatorcontrib>Hincal, A Atilla</creatorcontrib><creatorcontrib>Caliş, Sema</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Drug delivery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarisözen, Can</au><au>Arica, Betül</au><au>Orman, Mehmet N</au><au>Hincal, A Atilla</au><au>Caliş, Sema</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis</atitle><jtitle>Drug delivery</jtitle><addtitle>Drug Deliv</addtitle><date>2010-04</date><risdate>2010</risdate><volume>17</volume><issue>3</issue><spage>178</spage><epage>186</epage><pages>178-186</pages><eissn>1521-0464</eissn><abstract>Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2(3)) design was employed. The independent variables were polymer molecular weight, polymer concentration, and theoretical drug loading. Responses were the particle size, percentage of encapsulation efficiency, and the t(50%) release. The best formulation was prepared with 20% of PA and 1% of chitosan with medium molecular weight showing relative good yield of production (48.0 + or - 6.7%) and encapsulation efficiency (45.7 + or - 0.3%), and released the drug at a constant rate in 11 days.</abstract><cop>England</cop><pmid>20196705</pmid><doi>10.3109/10717541003667780</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1521-0464 |
| ispartof | Drug delivery, 2010-04, Vol.17 (3), p.178-186 |
| issn | 1521-0464 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733255860 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Arteries - physiology Calorimetry, Differential Scanning Chitosan - chemistry Desiccation Drug Compounding Graft Occlusion, Vascular - prevention & control Hyperplasia - prevention & control Microscopy, Electron, Scanning Microspheres Particle Size Prednisolone - administration & dosage Prednisolone - analogs & derivatives Prednisolone - therapeutic use Prodrugs - administration & dosage Prodrugs - therapeutic use Solubility Stents |
| title | Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T01%3A08%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Optimization%20of%20prednisolone%20acetate-loaded%20chitosan%20microspheres%20using%20a%202(3)%20factorial%20design%20for%20preventing%20restenosis&rft.jtitle=Drug%20delivery&rft.au=Saris%C3%B6zen,%20Can&rft.date=2010-04&rft.volume=17&rft.issue=3&rft.spage=178&rft.epage=186&rft.pages=178-186&rft.eissn=1521-0464&rft_id=info:doi/10.3109/10717541003667780&rft_dat=%3Cproquest_pubme%3E733255860%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733255860&rft_id=info:pmid/20196705&rfr_iscdi=true |