Mechanism of tumor cell-induced T-cell apoptosis mediated by galectin-1

Abstract Galectin-1 (Gal-1) has been implicated in tumor progression partly via the induction of T-cell apoptosis. However the mechanism of Gal-1 induced T-cell death was mostly studied using recombinant, soluble Gal-1 producing controversial results. To explore the true mechanism of Gal-1 and hence...

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Veröffentlicht in:	Immunology letters 2010-01, Vol.127 (2), p.108-118
Hauptverfasser:	Kovács-Sólyom, Ferenc, Blaskó, Andrea, Fajka-Boja, Roberta, Katona, Róbert L, Végh, Lea, Novák, Julianna, Szebeni, Gábor János, Krenács, László, Uher, Ferenc, Tubak, Vilmos, Kiss, Robert, Monostori, Éva
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Apoptosis - immunology Caspases - metabolism Cell Communication Coculture Techniques Disease Progression Galectin 1 - genetics Galectin 1 - immunology Galectin 1 - metabolism Galectin-1 Gene Expression Regulation, Neoplastic HeLa Cells Humans Jurkat Cells Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Membrane Potential, Mitochondrial Mitochondria - physiology Neoplasm Proteins - genetics Neoplasm Proteins - immunology Neoplasm Proteins - metabolism Neoplasms - immunology Neoplasms - pathology Neoplasms - physiopathology RNA, Small Interfering - genetics T-cell apoptosis T-Lymphocytes - immunology T-Lymphocytes - pathology Transgenes - genetics Tumor cells Tumor Escape Tumor-associated stroma cells ZAP-70 Protein-Tyrosine Kinase - genetics ZAP-70 Protein-Tyrosine Kinase - metabolism
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