Oropharyngeal tularemia – a differential diagnosis of tonsillopharyngitis and cervical lymphadenitis
Summary Francisella tularensis , the causative agent of tularemia, has been recognized as a human and zoonotic pathogen for almost 100 years. The increasing number of tularemia outbreaks in regions of Europe outside the classic endemic areas in recent years has prompted renewed interest in this rare...
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| Veröffentlicht in: | Wiener Klinische Wochenschrift 2010-02, Vol.122 (3-4), p.110-114 |
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| container_title | Wiener Klinische Wochenschrift |
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| creator | Dlugaiczyk, Julia Harrer, Thomas Zwerina, Jochen Traxdorf, Maximilian Schwarz, Stephan Splettstoesser, Wolf Geißdörfer, Walter Schoerner, Christoph |
| description | Summary
Francisella tularensis
, the causative agent of tularemia, has been recognized as a human and zoonotic pathogen for almost 100 years. The increasing number of tularemia outbreaks in regions of Europe outside the classic endemic areas in recent years has prompted renewed interest in this rare infectious disease. We report on a case of oropharyngeal tularemia in an 18-year-old girl from Bavaria (Germany) who presented with tonsillopharyngitis and cervical lymphadenitis. Strongly positive serological tests and PCR detection of
F. tularensis
subsp.
holarctica
in lymph node tissue led to the diagnosis of tularemia. After long-term treatment with doxycycline, partly in combination with ciprofloxacin, the patient recovered completely. Clinical presentation, diagnostics, treatment and recent epidemiological aspects of tularemia in Europe are discussed in this case report and review of the literature. |
| doi_str_mv | 10.1007/s00508-009-1274-8 |
| format | Article |
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Francisella tularensis
, the causative agent of tularemia, has been recognized as a human and zoonotic pathogen for almost 100 years. The increasing number of tularemia outbreaks in regions of Europe outside the classic endemic areas in recent years has prompted renewed interest in this rare infectious disease. We report on a case of oropharyngeal tularemia in an 18-year-old girl from Bavaria (Germany) who presented with tonsillopharyngitis and cervical lymphadenitis. Strongly positive serological tests and PCR detection of
F. tularensis
subsp.
holarctica
in lymph node tissue led to the diagnosis of tularemia. After long-term treatment with doxycycline, partly in combination with ciprofloxacin, the patient recovered completely. Clinical presentation, diagnostics, treatment and recent epidemiological aspects of tularemia in Europe are discussed in this case report and review of the literature.</description><identifier>ISSN: 0043-5325</identifier><identifier>EISSN: 1613-7671</identifier><identifier>DOI: 10.1007/s00508-009-1274-8</identifier><identifier>PMID: 20213378</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Case Report ; Diagnosis, Differential ; Endocrinology ; Female ; Gastroenterology ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Mouth Diseases - diagnosis ; Neck ; Pharyngeal Diseases - diagnosis ; Pharyngitis - complications ; Pharyngitis - diagnosis ; Pneumology/Respiratory System ; Tonsillitis - complications ; Tonsillitis - diagnosis ; Tuberculosis, Lymph Node - diagnosis ; Tularemia - diagnosis ; Young Adult</subject><ispartof>Wiener Klinische Wochenschrift, 2010-02, Vol.122 (3-4), p.110-114</ispartof><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-c522b210a036b648a26fc29df7070ddda6d3af0a1458702901fb432bd062606e3</citedby><cites>FETCH-LOGICAL-c409t-c522b210a036b648a26fc29df7070ddda6d3af0a1458702901fb432bd062606e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00508-009-1274-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00508-009-1274-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20213378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dlugaiczyk, Julia</creatorcontrib><creatorcontrib>Harrer, Thomas</creatorcontrib><creatorcontrib>Zwerina, Jochen</creatorcontrib><creatorcontrib>Traxdorf, Maximilian</creatorcontrib><creatorcontrib>Schwarz, Stephan</creatorcontrib><creatorcontrib>Splettstoesser, Wolf</creatorcontrib><creatorcontrib>Geißdörfer, Walter</creatorcontrib><creatorcontrib>Schoerner, Christoph</creatorcontrib><title>Oropharyngeal tularemia – a differential diagnosis of tonsillopharyngitis and cervical lymphadenitis</title><title>Wiener Klinische Wochenschrift</title><addtitle>Wien Klin Wochenschr</addtitle><addtitle>Wien Klin Wochenschr</addtitle><description>Summary
Francisella tularensis
, the causative agent of tularemia, has been recognized as a human and zoonotic pathogen for almost 100 years. The increasing number of tularemia outbreaks in regions of Europe outside the classic endemic areas in recent years has prompted renewed interest in this rare infectious disease. We report on a case of oropharyngeal tularemia in an 18-year-old girl from Bavaria (Germany) who presented with tonsillopharyngitis and cervical lymphadenitis. Strongly positive serological tests and PCR detection of
F. tularensis
subsp.
holarctica
in lymph node tissue led to the diagnosis of tularemia. After long-term treatment with doxycycline, partly in combination with ciprofloxacin, the patient recovered completely. Clinical presentation, diagnostics, treatment and recent epidemiological aspects of tularemia in Europe are discussed in this case report and review of the literature.</description><subject>Case Report</subject><subject>Diagnosis, Differential</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mouth Diseases - diagnosis</subject><subject>Neck</subject><subject>Pharyngeal Diseases - diagnosis</subject><subject>Pharyngitis - complications</subject><subject>Pharyngitis - diagnosis</subject><subject>Pneumology/Respiratory System</subject><subject>Tonsillitis - complications</subject><subject>Tonsillitis - diagnosis</subject><subject>Tuberculosis, Lymph Node - diagnosis</subject><subject>Tularemia - diagnosis</subject><subject>Young Adult</subject><issn>0043-5325</issn><issn>1613-7671</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1OwzAQxy0EoqXwACwoG5PhbCd2MqKKL6lSF5gtJ7aLKycpdoLExjvwhjwJrtoyMp10_4_T_RC6JHBDAMRtBCigxAAVJlTkuDxCU8IJw4ILcoymADnDBaPFBJ3FuAZgRS7IKZpQoIQxUU6RXYZ-86bCZ7cyymfD6FUwrVPZz9d3pjLtrDXBdINLonZq1fXRxay32dB30Xl_CLshrVWns8aED9ckt_9sk6ZNt5XO0YlVPpqL_Zyh14f7l_kTXiwfn-d3C9zkUA24KSitKQEFjNc8LxXltqGVtgIEaK0V10xZUCQvSgG0AmLrnNFaA6ccuGEzdL3r3YT-fTRxkK2LjfFedaYfoxQs0UinquQkO2cT-hiDsXITXJt-kQTklq7c0ZWJrtzSlWXKXO3bx7o1-i9xwJkMdGeISUpEg1z3Y-jSx_-0_gL2coeB</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Dlugaiczyk, Julia</creator><creator>Harrer, Thomas</creator><creator>Zwerina, Jochen</creator><creator>Traxdorf, Maximilian</creator><creator>Schwarz, Stephan</creator><creator>Splettstoesser, Wolf</creator><creator>Geißdörfer, Walter</creator><creator>Schoerner, Christoph</creator><general>Springer Vienna</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100201</creationdate><title>Oropharyngeal tularemia – a differential diagnosis of tonsillopharyngitis and cervical lymphadenitis</title><author>Dlugaiczyk, Julia ; Harrer, Thomas ; Zwerina, Jochen ; Traxdorf, Maximilian ; Schwarz, Stephan ; Splettstoesser, Wolf ; Geißdörfer, Walter ; Schoerner, Christoph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-c522b210a036b648a26fc29df7070ddda6d3af0a1458702901fb432bd062606e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Case Report</topic><topic>Diagnosis, Differential</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mouth Diseases - diagnosis</topic><topic>Neck</topic><topic>Pharyngeal Diseases - diagnosis</topic><topic>Pharyngitis - complications</topic><topic>Pharyngitis - diagnosis</topic><topic>Pneumology/Respiratory System</topic><topic>Tonsillitis - complications</topic><topic>Tonsillitis - diagnosis</topic><topic>Tuberculosis, Lymph Node - diagnosis</topic><topic>Tularemia - diagnosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dlugaiczyk, Julia</creatorcontrib><creatorcontrib>Harrer, Thomas</creatorcontrib><creatorcontrib>Zwerina, Jochen</creatorcontrib><creatorcontrib>Traxdorf, Maximilian</creatorcontrib><creatorcontrib>Schwarz, Stephan</creatorcontrib><creatorcontrib>Splettstoesser, Wolf</creatorcontrib><creatorcontrib>Geißdörfer, Walter</creatorcontrib><creatorcontrib>Schoerner, Christoph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Wiener Klinische Wochenschrift</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dlugaiczyk, Julia</au><au>Harrer, Thomas</au><au>Zwerina, Jochen</au><au>Traxdorf, Maximilian</au><au>Schwarz, Stephan</au><au>Splettstoesser, Wolf</au><au>Geißdörfer, Walter</au><au>Schoerner, Christoph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oropharyngeal tularemia – a differential diagnosis of tonsillopharyngitis and cervical lymphadenitis</atitle><jtitle>Wiener Klinische Wochenschrift</jtitle><stitle>Wien Klin Wochenschr</stitle><addtitle>Wien Klin Wochenschr</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>122</volume><issue>3-4</issue><spage>110</spage><epage>114</epage><pages>110-114</pages><issn>0043-5325</issn><eissn>1613-7671</eissn><abstract>Summary
Francisella tularensis
, the causative agent of tularemia, has been recognized as a human and zoonotic pathogen for almost 100 years. The increasing number of tularemia outbreaks in regions of Europe outside the classic endemic areas in recent years has prompted renewed interest in this rare infectious disease. We report on a case of oropharyngeal tularemia in an 18-year-old girl from Bavaria (Germany) who presented with tonsillopharyngitis and cervical lymphadenitis. Strongly positive serological tests and PCR detection of
F. tularensis
subsp.
holarctica
in lymph node tissue led to the diagnosis of tularemia. After long-term treatment with doxycycline, partly in combination with ciprofloxacin, the patient recovered completely. Clinical presentation, diagnostics, treatment and recent epidemiological aspects of tularemia in Europe are discussed in this case report and review of the literature.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>20213378</pmid><doi>10.1007/s00508-009-1274-8</doi><tpages>5</tpages></addata></record> |
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| subjects | Case Report Diagnosis, Differential Endocrinology Female Gastroenterology Humans Internal Medicine Medicine Medicine & Public Health Mouth Diseases - diagnosis Neck Pharyngeal Diseases - diagnosis Pharyngitis - complications Pharyngitis - diagnosis Pneumology/Respiratory System Tonsillitis - complications Tonsillitis - diagnosis Tuberculosis, Lymph Node - diagnosis Tularemia - diagnosis Young Adult |
| title | Oropharyngeal tularemia – a differential diagnosis of tonsillopharyngitis and cervical lymphadenitis |
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