Allosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: Implications for disease-associated kinases

Summary 1. The Src‐family protein tyrosine kinases (SFKs) are multidomain oncogenic protein tyrosine kinases. Their overactivation contributes to cancer formation and progression. Thus, synthetic inhibitors of SFKs are being developed as therapeutics for cancer treatment. Understanding the regulator...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2010-01, Vol.37 (1), p.93-101
Hauptverfasser:	Cheng, Heung-Chin, Johnson, Timothy M, Mills, Ryan D, Chong, Yuh-Ping, Chan, Khai-Chew, Culvenor, Janetta G
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site - genetics cancer Catalysis Drug Delivery Systems - methods Humans inhibitors Models, Biological Mutation - physiology Neoplasms - drug therapy oncogene phosphotransferase pp60C-Src Protein Conformation Protein Kinase Inhibitors - therapeutic use Protein Kinases - genetics Protein Kinases - metabolism protein tyrosine kinases Protein-Tyrosine Kinases - physiology proto-oncogene proteins Proto-Oncogene Proteins pp60(c-src) - physiology Signal Transduction Src-family kinases src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!