Plasma Cytokines and Future Risk of Non-Hodgkin Lymphoma (NHL): A Case-Control Study Nested in the Italian European Prospective Investigation into Cancer and Nutrition
Recently, biological markers related to the immune system such as cytokines have been studied to further understand the etiology of non-Hodgkin Lymphoma (NHL). However, to date, there are no studies that have studied cytokine levels prospectively in relation to NHL risk in the general population. Us...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2010-06, Vol.19 (6), p.1577-1584 |
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| creator | FATEMAEH SABERI HOSNIJEH KROP, Esmeralda J. M LINSEISEN, Jakob VINEIS, Paolo VERMEULEN, Roel SCOCCIANTI, Chiara KROGH, Vittorio PALLI, Domenico PANICO, Salvatore TUMINO, Rosario SACREDOTE, Carlotta NAWROLY, Niga PORTENGEN, Lützen |
| description | Recently, biological markers related to the immune system such as cytokines have been studied to further understand the etiology of non-Hodgkin Lymphoma (NHL). However, to date, there are no studies that have studied cytokine levels prospectively in relation to NHL risk in the general population.
Using bead-based immunoassays, plasma levels of 11 cytokines, 4 chemokines, and 1 adhesion molecules were measured in prediagnostic blood samples of 86 NHL cases and 86 matched controls (average time between blood collection and diagnosis, 4.5 y). Conditional logistic regression adjusted for body mass index and alcohol consumption was used to analyze the association between individual plasma cytokine levels and the risk of developing NHL.
In multivariate models, excluding cases diagnosed within 2 years after inclusion, we observed a significant association for interleukin 2 (IL2; P trend = 0.004), interferon (IFN)-gamma (P trend = 0.05), and intercellular adhesion molecule (ICAM) (P trend = 0.04). Subanalyses of B-cell NHL patients showed a significant association with IL2 (P trend = 0.003), tumor necrosis factor-alpha (TNF-alpha; P trend = 0.03), and ICAM (P trend = 0.04) and a borderline association with IL5 (P trend = 0.07) and IFN-gamma (P trend = 0.08).
The results of this study suggest, in a prospective setting, a possible association between plasma levels of IL2, ICAM, IFN-gamma, and TNF-alpha with NHL risk and provide some evidence that risk of NHL might be related to a downregulation of T helper 1 cytokines.
Identification of subtle changes in immune response regulation quantified by plasma cytokine levels possibly provides new insights in the etiology of NHL. |
| doi_str_mv | 10.1158/1055-9965.EPI-09-1237 |
| format | Article |
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Using bead-based immunoassays, plasma levels of 11 cytokines, 4 chemokines, and 1 adhesion molecules were measured in prediagnostic blood samples of 86 NHL cases and 86 matched controls (average time between blood collection and diagnosis, 4.5 y). Conditional logistic regression adjusted for body mass index and alcohol consumption was used to analyze the association between individual plasma cytokine levels and the risk of developing NHL.
In multivariate models, excluding cases diagnosed within 2 years after inclusion, we observed a significant association for interleukin 2 (IL2; P trend = 0.004), interferon (IFN)-gamma (P trend = 0.05), and intercellular adhesion molecule (ICAM) (P trend = 0.04). Subanalyses of B-cell NHL patients showed a significant association with IL2 (P trend = 0.003), tumor necrosis factor-alpha (TNF-alpha; P trend = 0.03), and ICAM (P trend = 0.04) and a borderline association with IL5 (P trend = 0.07) and IFN-gamma (P trend = 0.08).
The results of this study suggest, in a prospective setting, a possible association between plasma levels of IL2, ICAM, IFN-gamma, and TNF-alpha with NHL risk and provide some evidence that risk of NHL might be related to a downregulation of T helper 1 cytokines.
Identification of subtle changes in immune response regulation quantified by plasma cytokine levels possibly provides new insights in the etiology of NHL.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-09-1237</identifier><identifier>PMID: 20501772</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Biomarkers ; Case-Control Studies ; Cytokines - blood ; Down-Regulation ; Female ; Hematologic and hematopoietic diseases ; Humans ; Italy - epidemiology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Non-Hodgkin - epidemiology ; Lymphoma, Non-Hodgkin - immunology ; Male ; Medical sciences ; Middle Aged ; Prospective Studies ; Risk Factors ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2010-06, Vol.19 (6), p.1577-1584</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 AACR.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-ecb135866bca44dc1405143aa0ea00d38b5bb3214828d8cd8e35590dd0f2667e3</citedby><cites>FETCH-LOGICAL-c437t-ecb135866bca44dc1405143aa0ea00d38b5bb3214828d8cd8e35590dd0f2667e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22878859$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20501772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FATEMAEH SABERI HOSNIJEH</creatorcontrib><creatorcontrib>KROP, Esmeralda J. M</creatorcontrib><creatorcontrib>LINSEISEN, Jakob</creatorcontrib><creatorcontrib>VINEIS, Paolo</creatorcontrib><creatorcontrib>VERMEULEN, Roel</creatorcontrib><creatorcontrib>SCOCCIANTI, Chiara</creatorcontrib><creatorcontrib>KROGH, Vittorio</creatorcontrib><creatorcontrib>PALLI, Domenico</creatorcontrib><creatorcontrib>PANICO, Salvatore</creatorcontrib><creatorcontrib>TUMINO, Rosario</creatorcontrib><creatorcontrib>SACREDOTE, Carlotta</creatorcontrib><creatorcontrib>NAWROLY, Niga</creatorcontrib><creatorcontrib>PORTENGEN, Lützen</creatorcontrib><title>Plasma Cytokines and Future Risk of Non-Hodgkin Lymphoma (NHL): A Case-Control Study Nested in the Italian European Prospective Investigation into Cancer and Nutrition</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Recently, biological markers related to the immune system such as cytokines have been studied to further understand the etiology of non-Hodgkin Lymphoma (NHL). However, to date, there are no studies that have studied cytokine levels prospectively in relation to NHL risk in the general population.
Using bead-based immunoassays, plasma levels of 11 cytokines, 4 chemokines, and 1 adhesion molecules were measured in prediagnostic blood samples of 86 NHL cases and 86 matched controls (average time between blood collection and diagnosis, 4.5 y). Conditional logistic regression adjusted for body mass index and alcohol consumption was used to analyze the association between individual plasma cytokine levels and the risk of developing NHL.
In multivariate models, excluding cases diagnosed within 2 years after inclusion, we observed a significant association for interleukin 2 (IL2; P trend = 0.004), interferon (IFN)-gamma (P trend = 0.05), and intercellular adhesion molecule (ICAM) (P trend = 0.04). Subanalyses of B-cell NHL patients showed a significant association with IL2 (P trend = 0.003), tumor necrosis factor-alpha (TNF-alpha; P trend = 0.03), and ICAM (P trend = 0.04) and a borderline association with IL5 (P trend = 0.07) and IFN-gamma (P trend = 0.08).
The results of this study suggest, in a prospective setting, a possible association between plasma levels of IL2, ICAM, IFN-gamma, and TNF-alpha with NHL risk and provide some evidence that risk of NHL might be related to a downregulation of T helper 1 cytokines.
Identification of subtle changes in immune response regulation quantified by plasma cytokine levels possibly provides new insights in the etiology of NHL.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Case-Control Studies</subject><subject>Cytokines - blood</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Non-Hodgkin - epidemiology</subject><subject>Lymphoma, Non-Hodgkin - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkd1u3CAQha2qVZOmfYRW3FRJLkjBGIN7F1mb7kqr7ao_1wgDTmhscAFH2ifqaxYnm_aKkeY7w8w5RfEeoyuMKf-EEaWwaWp6tdpvIGogLgl7UZxiSjhkjNKXuX5mToo3Mf5CCLGG0tfFSYkowoyVp8Wf_SDjKEF7SP7eOhOBdBrczGkOBnyz8R74Huy8g2uvbzMAtodxuvNZcbFbby8_g2vQymhg610KfgDf06wPYGdiMhpkPN0ZsElysNKB1Rz8ZHKxDz5ORiX7kJvuIcP2VibrXVYknwc6ZcLjIrs5Bbt03havejlE8-74nhU_b1Y_2jXcfv2yaa-3UFWEJWhUhwnldd0pWVVa4QpRXBEpkZEIacI72nWkxBUvueZKc0MobZDWqC_rmhlyVpw_zZ2C_z3nzcRoozLDIJ3xcxSMkJKiqkaZpE-kytfEYHoxBTvKcBAYiSUisdgvFvtFjkigRiwRZd2H4w9zNxr9T_WcSQY-HgEZlRz6kO2w8T9XcsY5bchfCIibIg</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>FATEMAEH SABERI HOSNIJEH</creator><creator>KROP, Esmeralda J. 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Myelofibrosis</topic><topic>Lymphoma, Non-Hodgkin - epidemiology</topic><topic>Lymphoma, Non-Hodgkin - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FATEMAEH SABERI HOSNIJEH</creatorcontrib><creatorcontrib>KROP, Esmeralda J. 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M</au><au>LINSEISEN, Jakob</au><au>VINEIS, Paolo</au><au>VERMEULEN, Roel</au><au>SCOCCIANTI, Chiara</au><au>KROGH, Vittorio</au><au>PALLI, Domenico</au><au>PANICO, Salvatore</au><au>TUMINO, Rosario</au><au>SACREDOTE, Carlotta</au><au>NAWROLY, Niga</au><au>PORTENGEN, Lützen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Cytokines and Future Risk of Non-Hodgkin Lymphoma (NHL): A Case-Control Study Nested in the Italian European Prospective Investigation into Cancer and Nutrition</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>19</volume><issue>6</issue><spage>1577</spage><epage>1584</epage><pages>1577-1584</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>Recently, biological markers related to the immune system such as cytokines have been studied to further understand the etiology of non-Hodgkin Lymphoma (NHL). However, to date, there are no studies that have studied cytokine levels prospectively in relation to NHL risk in the general population.
Using bead-based immunoassays, plasma levels of 11 cytokines, 4 chemokines, and 1 adhesion molecules were measured in prediagnostic blood samples of 86 NHL cases and 86 matched controls (average time between blood collection and diagnosis, 4.5 y). Conditional logistic regression adjusted for body mass index and alcohol consumption was used to analyze the association between individual plasma cytokine levels and the risk of developing NHL.
In multivariate models, excluding cases diagnosed within 2 years after inclusion, we observed a significant association for interleukin 2 (IL2; P trend = 0.004), interferon (IFN)-gamma (P trend = 0.05), and intercellular adhesion molecule (ICAM) (P trend = 0.04). Subanalyses of B-cell NHL patients showed a significant association with IL2 (P trend = 0.003), tumor necrosis factor-alpha (TNF-alpha; P trend = 0.03), and ICAM (P trend = 0.04) and a borderline association with IL5 (P trend = 0.07) and IFN-gamma (P trend = 0.08).
The results of this study suggest, in a prospective setting, a possible association between plasma levels of IL2, ICAM, IFN-gamma, and TNF-alpha with NHL risk and provide some evidence that risk of NHL might be related to a downregulation of T helper 1 cytokines.
Identification of subtle changes in immune response regulation quantified by plasma cytokine levels possibly provides new insights in the etiology of NHL.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>20501772</pmid><doi>10.1158/1055-9965.EPI-09-1237</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2010-06, Vol.19 (6), p.1577-1584 |
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| subjects | Adult Aged Biological and medical sciences Biomarkers Case-Control Studies Cytokines - blood Down-Regulation Female Hematologic and hematopoietic diseases Humans Italy - epidemiology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - epidemiology Lymphoma, Non-Hodgkin - immunology Male Medical sciences Middle Aged Prospective Studies Risk Factors Tumors |
| title | Plasma Cytokines and Future Risk of Non-Hodgkin Lymphoma (NHL): A Case-Control Study Nested in the Italian European Prospective Investigation into Cancer and Nutrition |
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