Endogenous protectant kynurenic acid in amyotrophic lateral sclerosis

Objectives – Excitotoxicity may play a role in neurodegeneration in amyotrophic lateral sclerosis (ALS). Kynurenic acid (KYNA), an endogenous antagonist of excitatory amino acid receptors, may inhibit excitotoxic lesions. The aim of this study was to determine the concentration of KYNA in ALS patie...

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Veröffentlicht in:	Acta neurologica Scandinavica 2003-06, Vol.107 (6), p.412-418
Hauptverfasser:	Iłżecka, J., Kocki, T., Stelmasiak, Z., Turski, W. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - cerebrospinal fluid Biological and medical sciences Case-Control Studies Chromatography, High Pressure Liquid Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Excitatory Amino Acid Antagonists - blood Excitatory Amino Acid Antagonists - cerebrospinal fluid Extremities Female human Humans kynurenic acid Kynurenic Acid - blood Kynurenic Acid - cerebrospinal fluid Male Medical sciences Medulla Oblongata Middle Aged neurodegeneration Neurology Neuroprotective Agents - blood Neuroprotective Agents - cerebrospinal fluid Sex Factors
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