Cytotoxic activities of some Greek Labiatae herbs
Nineteen methanolic crude plant extracts of Labiatae family, collected in Greece from different locations, were evaluated for cytotoxic activity against brine shrimps and three human cancer cell lines along with a normal mouse cells as a control cell line. In the brine shrimp lethality test, Mentha...
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| Veröffentlicht in: | Phytotherapy research 2003-05, Vol.17 (5), p.472-476 |
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| container_end_page | 476 |
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| creator | Badisa, R. B. Tzakou, O. Couladis, M. Pilarinou, E. |
| description | Nineteen methanolic crude plant extracts of Labiatae family, collected in Greece from different locations, were evaluated for cytotoxic activity against brine shrimps and three human cancer cell lines along with a normal mouse cells as a control cell line. In the brine shrimp lethality test, Mentha pulegium was the only sample found to be active with an LC50 value 347.3 µg/ml, while all remaining samples had LC50 values greater than 1000 µg/ml. In case of Caco‐2 and HepG2 cell lines, only one sample, namely Thymus parnassicus Halacsy, was active with LC50 values 44.6 and 50.3 µg/ml respectively, while against MCF‐7 cell line, two samples, namely, Clinopodium vulgare L. (LC50: 60.4 µg/ml), and Thymus parnassicus Halacsy (LC50: 54.7 µg/ml), were found active. Copyright © 2003 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.1175 |
| format | Article |
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B. ; Tzakou, O. ; Couladis, M. ; Pilarinou, E.</creator><creatorcontrib>Badisa, R. B. ; Tzakou, O. ; Couladis, M. ; Pilarinou, E.</creatorcontrib><description>Nineteen methanolic crude plant extracts of Labiatae family, collected in Greece from different locations, were evaluated for cytotoxic activity against brine shrimps and three human cancer cell lines along with a normal mouse cells as a control cell line. In the brine shrimp lethality test, Mentha pulegium was the only sample found to be active with an LC50 value 347.3 µg/ml, while all remaining samples had LC50 values greater than 1000 µg/ml. In case of Caco‐2 and HepG2 cell lines, only one sample, namely Thymus parnassicus Halacsy, was active with LC50 values 44.6 and 50.3 µg/ml respectively, while against MCF‐7 cell line, two samples, namely, Clinopodium vulgare L. (LC50: 60.4 µg/ml), and Thymus parnassicus Halacsy (LC50: 54.7 µg/ml), were found active. 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B.</creatorcontrib><creatorcontrib>Tzakou, O.</creatorcontrib><creatorcontrib>Couladis, M.</creatorcontrib><creatorcontrib>Pilarinou, E.</creatorcontrib><title>Cytotoxic activities of some Greek Labiatae herbs</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Nineteen methanolic crude plant extracts of Labiatae family, collected in Greece from different locations, were evaluated for cytotoxic activity against brine shrimps and three human cancer cell lines along with a normal mouse cells as a control cell line. In the brine shrimp lethality test, Mentha pulegium was the only sample found to be active with an LC50 value 347.3 µg/ml, while all remaining samples had LC50 values greater than 1000 µg/ml. In case of Caco‐2 and HepG2 cell lines, only one sample, namely Thymus parnassicus Halacsy, was active with LC50 values 44.6 and 50.3 µg/ml respectively, while against MCF‐7 cell line, two samples, namely, Clinopodium vulgare L. (LC50: 60.4 µg/ml), and Thymus parnassicus Halacsy (LC50: 54.7 µg/ml), were found active. Copyright © 2003 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Artemia - drug effects</subject><subject>Biological and medical sciences</subject><subject>Brine shrimps</subject><subject>Caco-2</subject><subject>Caco-2 Cells - drug effects</subject><subject>cytotoxic activities</subject><subject>General pharmacology</subject><subject>Greece</subject><subject>HepG2</subject><subject>Humans</subject><subject>Labiatae species</subject><subject>Lamiaceae</subject><subject>MCF-7</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E9LwzAYx_Egis4p-AqkF8VL5_Mk6ZIeZegUh24y_9xCmqYY160z6dS9eysrevL0XD48P_gScoTQQwB6vqx9D1EkW6SDkKYxJoJtkw6kCcYc5cse2Q_hDQBSCnyX7CEVXKYSOwQH67qqqy9nIm1q9-FqZ0NUFVGo5jYaemtn0UhnTtfaRq_WZ-GA7BS6DPawvV3yeHU5HVzHo_vhzeBiFBsmkyROmJYWTG6LNE-okKkpUBqds1z3oVkvqMRMIKWIEljO84xCX2eScU0pZci65HTzd-mr95UNtZq7YGxZ6oWtVkEJxigHzht4toHGVyF4W6ild3Pt1wpB_eRRTR71k6ehx-3PVTa3-R9sezTgpAU6GF0WXi-MC3-Oiz4yAY2LN-7TlXb976AaTx_a4da7UNuvX6_9TPUFa-Dz3VDJJ5jcTsZUjdg3huaIuw</recordid><startdate>200305</startdate><enddate>200305</enddate><creator>Badisa, R. B.</creator><creator>Tzakou, O.</creator><creator>Couladis, M.</creator><creator>Pilarinou, E.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200305</creationdate><title>Cytotoxic activities of some Greek Labiatae herbs</title><author>Badisa, R. B. ; Tzakou, O. ; Couladis, M. ; Pilarinou, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3855-53a8e0cdef9d52789cf18cad3da60748f281b712211803d4db206ab834a222313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Artemia - drug effects</topic><topic>Biological and medical sciences</topic><topic>Brine shrimps</topic><topic>Caco-2</topic><topic>Caco-2 Cells - drug effects</topic><topic>cytotoxic activities</topic><topic>General pharmacology</topic><topic>Greece</topic><topic>HepG2</topic><topic>Humans</topic><topic>Labiatae species</topic><topic>Lamiaceae</topic><topic>MCF-7</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>Tumor Cells, Cultured - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Badisa, R. B.</creatorcontrib><creatorcontrib>Tzakou, O.</creatorcontrib><creatorcontrib>Couladis, M.</creatorcontrib><creatorcontrib>Pilarinou, E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Badisa, R. B.</au><au>Tzakou, O.</au><au>Couladis, M.</au><au>Pilarinou, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic activities of some Greek Labiatae herbs</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2003-05</date><risdate>2003</risdate><volume>17</volume><issue>5</issue><spage>472</spage><epage>476</epage><pages>472-476</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Nineteen methanolic crude plant extracts of Labiatae family, collected in Greece from different locations, were evaluated for cytotoxic activity against brine shrimps and three human cancer cell lines along with a normal mouse cells as a control cell line. In the brine shrimp lethality test, Mentha pulegium was the only sample found to be active with an LC50 value 347.3 µg/ml, while all remaining samples had LC50 values greater than 1000 µg/ml. 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| subjects | Animals Antineoplastic Agents, Phytogenic - pharmacology Artemia - drug effects Biological and medical sciences Brine shrimps Caco-2 Caco-2 Cells - drug effects cytotoxic activities General pharmacology Greece HepG2 Humans Labiatae species Lamiaceae MCF-7 Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Tumor Cells, Cultured - drug effects |
| title | Cytotoxic activities of some Greek Labiatae herbs |
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