Monooxygenase Induction and Chlorobiphenyls in the Deep-Sea Fish Coryphaenoides armatus
Inhibition of liver microsomal ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase activities by α-naphthoflavone and by polyclonal antibodies to hydrocarbon-inducible cytochrome P-450E from teleost liver indicated a xenobiotic-induced origin of these activities in the deep-sea fish Coryph...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1986-03, Vol.231 (4743), p.1287-1289 |
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| creator | Stegeman, John J. Kloepper-Sams, Pamela J. Farrington, John W. |
| description | Inhibition of liver microsomal ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase activities by α-naphthoflavone and by polyclonal antibodies to hydrocarbon-inducible cytochrome P-450E from teleost liver indicated a xenobiotic-induced origin of these activities in the deep-sea fish Coryphaenoides armatus. Specific recognition of a protein by antibodies to P-450E in an immunoblot assay further indicated xenobiotic-induced cytochrome P-450 in these animals. Levels of apparently induced cytochrome P-450 and monooxygenase activity correlated positively with the tissue content of chlorobiphenyls of known inducing activity, implicating such compounds in biochemical effects occurring in the deep ocean. |
| doi_str_mv | 10.1126/science.231.4743.1287 |
| format | Article |
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Specific recognition of a protein by antibodies to P-450E in an immunoblot assay further indicated xenobiotic-induced cytochrome P-450 in these animals. Levels of apparently induced cytochrome P-450 and monooxygenase activity correlated positively with the tissue content of chlorobiphenyls of known inducing activity, implicating such compounds in biochemical effects occurring in the deep ocean.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.231.4743.1287</identifier><identifier>PMID: 17839567</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Abyssal zone ; Analytical, structural and metabolic biochemistry ; Animals ; Antibodies ; Biochemistry ; Biological and medical sciences ; Canyons ; Coryphaenoides armatus ; Cytochromes ; Deep-sea fishes ; Enzymes ; Enzymes and enzyme inhibitors ; Fish ; Fishes, Deep-sea ; Fundamental and applied biological sciences. Psychology ; Hazardous materials ; Liver ; Marine ; Marine biology ; Marine fishes ; Oceans ; Oxidoreductases ; Physiological aspects ; Pollution ; Polyclonal antibodies ; Xenobiotics</subject><ispartof>Science (American Association for the Advancement of Science), 1986-03, Vol.231 (4743), p.1287-1289</ispartof><rights>Copyright 1986 The American Association for the Advancement of Science</rights><rights>1986 INIST-CNRS</rights><rights>COPYRIGHT 1986 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1986 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Mar 14, 1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c744t-e0cc9af209efbd4953acfcdd1e45688695e53f3e15de6d5826cd117d9b3e74123</citedby><cites>FETCH-LOGICAL-c744t-e0cc9af209efbd4953acfcdd1e45688695e53f3e15de6d5826cd117d9b3e74123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1696153$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1696153$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8676302$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17839567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stegeman, John J.</creatorcontrib><creatorcontrib>Kloepper-Sams, Pamela J.</creatorcontrib><creatorcontrib>Farrington, John W.</creatorcontrib><title>Monooxygenase Induction and Chlorobiphenyls in the Deep-Sea Fish Coryphaenoides armatus</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Inhibition of liver microsomal ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase activities by α-naphthoflavone and by polyclonal antibodies to hydrocarbon-inducible cytochrome P-450E from teleost liver indicated a xenobiotic-induced origin of these activities in the deep-sea fish Coryphaenoides armatus. Specific recognition of a protein by antibodies to P-450E in an immunoblot assay further indicated xenobiotic-induced cytochrome P-450 in these animals. Levels of apparently induced cytochrome P-450 and monooxygenase activity correlated positively with the tissue content of chlorobiphenyls of known inducing activity, implicating such compounds in biochemical effects occurring in the deep ocean.</description><subject>Abyssal zone</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Canyons</subject><subject>Coryphaenoides armatus</subject><subject>Cytochromes</subject><subject>Deep-sea fishes</subject><subject>Enzymes</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Fish</subject><subject>Fishes, Deep-sea</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hazardous materials</subject><subject>Liver</subject><subject>Marine</subject><subject>Marine biology</subject><subject>Marine fishes</subject><subject>Oceans</subject><subject>Oxidoreductases</subject><subject>Physiological aspects</subject><subject>Pollution</subject><subject>Polyclonal antibodies</subject><subject>Xenobiotics</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNqN08tuEzEUBuARAtFQeANAowrRRZngu8fLEmiIFMiiXJaW4zmTTDWxgz0jNW-Po0S0oIhGXliyP5-Fz_mz7BVGQ4yJeB9tA87CkFA8ZJLRISalfJQNMFK8UATRx9kAISqKEkl-kj2L8QahdKfo0-wEy5IqLuQg-_nFO-9vNwtwJkI-cVVvu8a73LgqHy1bH_y8WS_BbdqYNy7vlpB_BFgX12DyqyYu85EPm_XSgPNNBTE3YWW6Pj7PntSmjfBiv59m368-fRt9Lqaz8WR0OS2sZKwrAFmrTE2QgnpeMcWpsbWtKgyMi7IUigOnNQXMKxAVL4mwFcayUnMKkmFCT7PzXd118L96iJ1eNdFC2xoHvo9aUkpoyZFM8u1_JRVMEV7iByHBuKSciQchZlQShlGCZ__AG98Hl_4lFaOcMMZUQhc7tDAt6MbVvgvGpr5AMK13UDfp-DKVZArRpN8d0GlVsGrsAX7-F0-ig9tuYfoY9eT667Fy9uNY-WF8pCzH0_vy4pC0vm1hATqNzmh2X_OdtsHHGKDW69CsTNhojPQ2JXqfEp1Sorcp0duUpHev9_3o5yuo7l7tY5HAmz0w0Zq2DsbZJv5xpZCCou3wvdyxm9j5cFdGKIE5pb8B0mEg5g</recordid><startdate>19860314</startdate><enddate>19860314</enddate><creator>Stegeman, John J.</creator><creator>Kloepper-Sams, Pamela J.</creator><creator>Farrington, John W.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7TV</scope><scope>7U7</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>7TN</scope><scope>H95</scope><scope>7X8</scope></search><sort><creationdate>19860314</creationdate><title>Monooxygenase Induction and Chlorobiphenyls in the Deep-Sea Fish Coryphaenoides armatus</title><author>Stegeman, John J. ; Kloepper-Sams, Pamela J. ; Farrington, John W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c744t-e0cc9af209efbd4953acfcdd1e45688695e53f3e15de6d5826cd117d9b3e74123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Abyssal zone</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Canyons</topic><topic>Coryphaenoides armatus</topic><topic>Cytochromes</topic><topic>Deep-sea fishes</topic><topic>Enzymes</topic><topic>Enzymes and enzyme inhibitors</topic><topic>Fish</topic><topic>Fishes, Deep-sea</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hazardous materials</topic><topic>Liver</topic><topic>Marine</topic><topic>Marine biology</topic><topic>Marine fishes</topic><topic>Oceans</topic><topic>Oxidoreductases</topic><topic>Physiological aspects</topic><topic>Pollution</topic><topic>Polyclonal antibodies</topic><topic>Xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stegeman, John J.</creatorcontrib><creatorcontrib>Kloepper-Sams, Pamela J.</creatorcontrib><creatorcontrib>Farrington, John W.</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Oceanic Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stegeman, John J.</au><au>Kloepper-Sams, Pamela J.</au><au>Farrington, John W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monooxygenase Induction and Chlorobiphenyls in the Deep-Sea Fish Coryphaenoides armatus</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1986-03-14</date><risdate>1986</risdate><volume>231</volume><issue>4743</issue><spage>1287</spage><epage>1289</epage><pages>1287-1289</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Inhibition of liver microsomal ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase activities by α-naphthoflavone and by polyclonal antibodies to hydrocarbon-inducible cytochrome P-450E from teleost liver indicated a xenobiotic-induced origin of these activities in the deep-sea fish Coryphaenoides armatus. Specific recognition of a protein by antibodies to P-450E in an immunoblot assay further indicated xenobiotic-induced cytochrome P-450 in these animals. Levels of apparently induced cytochrome P-450 and monooxygenase activity correlated positively with the tissue content of chlorobiphenyls of known inducing activity, implicating such compounds in biochemical effects occurring in the deep ocean.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>17839567</pmid><doi>10.1126/science.231.4743.1287</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1986-03, Vol.231 (4743), p.1287-1289 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733238507 |
| source | JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Abyssal zone Analytical, structural and metabolic biochemistry Animals Antibodies Biochemistry Biological and medical sciences Canyons Coryphaenoides armatus Cytochromes Deep-sea fishes Enzymes Enzymes and enzyme inhibitors Fish Fishes, Deep-sea Fundamental and applied biological sciences. Psychology Hazardous materials Liver Marine Marine biology Marine fishes Oceans Oxidoreductases Physiological aspects Pollution Polyclonal antibodies Xenobiotics |
| title | Monooxygenase Induction and Chlorobiphenyls in the Deep-Sea Fish Coryphaenoides armatus |
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