Gastroduodenitis and Helicobacter pylori in Nigerians: histopathological assessment of endoscopic biopsies

Morphologic changes seen in the endoscopic biopsies are dynamic and could be predictive of more important sequelae of chronic H. pylori gastritis such as gastric carcinoma and lymphoma. The objective of the study was to review the biopsy appearances of endoscopic gastroduodenal biopsies using the up...

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Veröffentlicht in:The Nigerian postgraduate medical journal 2009-12, Vol.16 (4), p.264-267
Hauptverfasser: Badmos, K B, Ojo, O S, Olasode, O S, Arigbabu, A O
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container_title The Nigerian postgraduate medical journal
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creator Badmos, K B
Ojo, O S
Olasode, O S
Arigbabu, A O
description Morphologic changes seen in the endoscopic biopsies are dynamic and could be predictive of more important sequelae of chronic H. pylori gastritis such as gastric carcinoma and lymphoma. The objective of the study was to review the biopsy appearances of endoscopic gastroduodenal biopsies using the updated Sydney System of classification in order to throw some light on the biology of gastroduodenitis. A retrospective review of all endoscopic gastroduodenal biopsies received in the department of Morbid Anatomy of Obafemi Awolowo University Teaching Hospitals Complex between 1994 and 2003 was undertaken. Grading of the chronicity, activity, atrophy, H. pylori density and metaplasia were done using the updated Sydney System of classification and grading. A total of 1047 gastric and 47 duodenal biopsies from 1047 patients were reviewed. There was evidence of significant chronic gastritis in 98.1% of the gastric biopsies and in 78.0% of these, H. pylori was the main identifiable aetiological agent. Marked atrophic changes and intestinal metaplasia that are known to predispose to gastric malignances were seen in 4.9% and 9.3% of our cases respectively. Chronic duodenitis was seen in 83% of the duodenal biopsies and in 29.6%, H. pylori was seen on a background of gastric metaplasia. The prevalence of H. pylori was high and it was the single most important aetiological factor responsible for the biopsy changes associated with chronic gastroduodenitis.
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source MEDLINE; EZB-FREE-00999 freely available EZB journals
subjects Adolescent
Adult
Age Distribution
Aged
Biopsy
Child
Child, Preschool
Chronic Disease
Duodenitis - microbiology
Duodenitis - pathology
Endoscopy
Female
Gastritis - microbiology
Gastritis - pathology
Helicobacter Infections - complications
Helicobacter Infections - pathology
Helicobacter pylori - isolation & purification
Humans
Infant
Infant, Newborn
Male
Middle Aged
Nigeria
Prevalence
Retrospective Studies
Risk Factors
Young Adult
title Gastroduodenitis and Helicobacter pylori in Nigerians: histopathological assessment of endoscopic biopsies
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