How to predict product yield in kinetically controlled enzymatic peptide synthesis

How to predict product yield in kinetically controlled enzymatic peptide synthesis

The published theory of kinetically controlled enzymatic peptide synthesis needed experimental verification. We carried out the measurement of the peptide yield and estimation of the key parameters α and β for papain‐catalyzed synthesis of Mal‐L‐Phe‐L‐Ala‐LLeuNH2 from Mal‐L‐Phe‐L‐AlaOMe and L‐LeuNH2...

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Veröffentlicht in:Biotechnology and bioengineering 1992-07, Vol.40 (3), p.432-436
Hauptverfasser: Gololobov, Mikhail Yu, Kozlova, Elena V., Borisov, Ivan L., Schellenberger, Ute, Schellenberger, Volker, Jakubke, Hans-Dieter
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Biotechnology
Enzyme engineering
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Miscellaneous
papain-catalyzed peptide synthesis
progress curve kinetics
theory of enzymatic peptide synthesis
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container_end_page 436
container_issue 3
container_start_page 432
container_title Biotechnology and bioengineering
container_volume 40
creator Gololobov, Mikhail Yu
Kozlova, Elena V.
Borisov, Ivan L.
Schellenberger, Ute
Schellenberger, Volker
Jakubke, Hans-Dieter
description The published theory of kinetically controlled enzymatic peptide synthesis needed experimental verification. We carried out the measurement of the peptide yield and estimation of the key parameters α and β for papain‐catalyzed synthesis of Mal‐L‐Phe‐L‐Ala‐LLeuNH2 from Mal‐L‐Phe‐L‐AlaOMe and L‐LeuNH2. The experimental results demonstrate that this theory adequately describes the real process. © 1992 John Wiley & Sons, Inc.
doi_str_mv 10.1002/bit.260400313
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source Wiley Online Library Journals Frontfile Complete
subjects Biological and medical sciences
Biotechnology
Enzyme engineering
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Miscellaneous
papain-catalyzed peptide synthesis
progress curve kinetics
theory of enzymatic peptide synthesis
title How to predict product yield in kinetically controlled enzymatic peptide synthesis
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