Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of alpha-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker r...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic & biomolecular chemistry 2010-03, Vol.8 (6), p.1399-1405
Hauptverfasser:	Zhang, Guang-Wu, Zheng, Dong-Hua, Nie, Jing, Wang, Teng, Ma, Jun-An
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - chemistry Amines - chemistry Catalysis Cyanides - chemistry Ketones - chemistry Magnetic Resonance Spectroscopy Spectrometry, Mass, Electrospray Ionization Trimethylsilyl Compounds - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!