Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man

1. Pharmacokinetics of dofetilide were studied in man, dog, rat and mouse after single i.v. and oral doses of dofetilide or 14C-dofetilide. 2. Dofetilide was absorbed completely in all species. Low metabolic clearance in man resulted in complete bioavailability following oral administration. Higher...

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Veröffentlicht in:	Xenobiotica 1992, Vol.22 (6), p.709-719
Hauptverfasser:	Smith, D. A., Rasmussen, H. S., Stopher, D. A., Walker, D. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Arrhythmia Agents - blood Anti-Arrhythmia Agents - pharmacokinetics Anti-Arrhythmia Agents - urine Antiarythmic agents Biological and medical sciences Cardiovascular system Dogs Female Humans Infusions, Intravenous Injections, Intravenous Male Medical sciences Mice Pharmacology. Drug treatments Phenethylamines - blood Phenethylamines - pharmacokinetics Phenethylamines - urine Rats Rats, Sprague-Dawley Sulfonamides - blood Sulfonamides - pharmacokinetics Sulfonamides - urine
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