Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs

Summary Virtually all new tuberculosis vaccine candidates are tested in animals using the laboratory strains H37Rv or Erdman. However, naturally occurring M. tuberculosis infections are caused by strains that are widely different in phenotype and genotype. Very little is known about the characterist...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2009-05, Vol.89 (3), p.203-209
Hauptverfasser:	Palanisamy, Gopinath S, DuTeau, Nancy, Eisenach, Kathleen D, Cave, Donald M, Theus, Susan A, Kreiswirth, Barry N, Basaraba, Randall J, Orme, Ian M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Resistance, Multiple, Bacterial - genetics Female Genotype Guinea pig model Guinea Pigs Infectious Disease Lung - pathology MDR tuberculosis Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - pathogenicity Pulmonary/Respiratory Species Specificity Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - pathology Virulence W-Beijing strains
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