Identification of fetuses with hemoglobin Bart's disease using middle cerebral artery peak systolic velocity
Objectives To determine the sensitivity and specificity of middle cerebral artery peak systolic velocity (MCA‐PSV) in mid‐pregnancy for the identification of homozygous α‐thalassemia‐1 (hemoglobin (Hb) Bart's disease) in fetuses at risk of the disease. Methods A total of 88 pregnancies (91 fetu...
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| Veröffentlicht in: | Ultrasound in obstetrics & gynecology 2009-06, Vol.33 (6), p.694-697 |
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| creator | Srisupundit, K. Piyamongkol, W. Tongsong, T. |
| description | Objectives
To determine the sensitivity and specificity of middle cerebral artery peak systolic velocity (MCA‐PSV) in mid‐pregnancy for the identification of homozygous α‐thalassemia‐1 (hemoglobin (Hb) Bart's disease) in fetuses at risk of the disease.
Methods
A total of 88 pregnancies (91 fetuses) at risk of Hb Bart's disease and undergoing MCA‐PSV measurement before cordocentesis at 18–22 weeks of gestation were recruited into the study. Definitive diagnosis was made using the gold standard technique of Hb typing by high‐performance liquid chromatography.
Results
The mean ± SD age of the 88 pregnant women recruited into the study was 28.3 ± 5.7 years, the gestational age was 18.8 ± 1.1 weeks and the incidence of Hb Bart's disease was 22% (20 fetuses). Using MCA‐PSV above 1.5 multiples of the median as a cut‐off point, the sensitivity of MCA‐PSV for detecting affected fetuses was 85% (17/20 cases), with a specificity of 100%, and positive and negative predictive values of 100% and 95.9% respectively. Three of 20 fetuses with Hb Bart's disease had normal MCA‐PSV.
Conclusions
MCA‐PSV assessment in mid‐pregnancy is a useful method for identifying Hb Bart's disease with high sensitivity and specificity among fetuses at risk, and may allow avoidance of unnecessary cordocentesis in some cases. Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/uog.6342 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733220833</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20072274</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4152-e57ff6d22f7582d510ca4e61066d5933abaff81cc0aae759c383dedd388b223c3</originalsourceid><addsrcrecordid>eNp90UFv1DAQBWALgehSkPgFyBcol5SxHTvJsVRQKlXqhZ4jxx5vDd548SRU-fek7ApOcJrLp_ekeYy9FnAuAOSHOW_PjarlE7YRtekqaEA_ZRvoDFSN6eQJe0H0DQBMrcxzdiI6pUErsWHp2uM4xRCdnWIeeQ484DQTEn-I0z2_x13epjzEkX-0ZToj7iOhJeQzxXHLd9H7hNxhwaHYxFeDZeF7tN85LTTlFB3_iSm7OC0v2bNgE-Gr4z1ld58_fb38Ut3cXl1fXtxUrhZaVqibEIyXMjS6lV4LcLZGI8AYrzul7GBDaIVzYC02unOqVR69V207SKmcOmVnh9x9yT9mpKnfRXKYkh0xz9Q3SkkJrVKrfPdfKQEaKZt6he8P0JVMVDD0-xJ3tiy9gP5xg37doH_cYKVvjpnzsEP_Fx6fvoK3R2DJ2RSKHV2kP04KLbramNVVB_cQEy7_LOzvbq9-F_8CYASemA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20072274</pqid></control><display><type>article</type><title>Identification of fetuses with hemoglobin Bart's disease using middle cerebral artery peak systolic velocity</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><creator>Srisupundit, K. ; Piyamongkol, W. ; Tongsong, T.</creator><creatorcontrib>Srisupundit, K. ; Piyamongkol, W. ; Tongsong, T.</creatorcontrib><description>Objectives
To determine the sensitivity and specificity of middle cerebral artery peak systolic velocity (MCA‐PSV) in mid‐pregnancy for the identification of homozygous α‐thalassemia‐1 (hemoglobin (Hb) Bart's disease) in fetuses at risk of the disease.
Methods
A total of 88 pregnancies (91 fetuses) at risk of Hb Bart's disease and undergoing MCA‐PSV measurement before cordocentesis at 18–22 weeks of gestation were recruited into the study. Definitive diagnosis was made using the gold standard technique of Hb typing by high‐performance liquid chromatography.
Results
The mean ± SD age of the 88 pregnant women recruited into the study was 28.3 ± 5.7 years, the gestational age was 18.8 ± 1.1 weeks and the incidence of Hb Bart's disease was 22% (20 fetuses). Using MCA‐PSV above 1.5 multiples of the median as a cut‐off point, the sensitivity of MCA‐PSV for detecting affected fetuses was 85% (17/20 cases), with a specificity of 100%, and positive and negative predictive values of 100% and 95.9% respectively. Three of 20 fetuses with Hb Bart's disease had normal MCA‐PSV.
Conclusions
MCA‐PSV assessment in mid‐pregnancy is a useful method for identifying Hb Bart's disease with high sensitivity and specificity among fetuses at risk, and may allow avoidance of unnecessary cordocentesis in some cases. Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0960-7692</identifier><identifier>EISSN: 1469-0705</identifier><identifier>DOI: 10.1002/uog.6342</identifier><identifier>PMID: 19350531</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; alpha-Thalassemia - blood ; alpha-Thalassemia - diagnostic imaging ; alpha-Thalassemia - physiopathology ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; Blood Flow Velocity - physiology ; Chromatography, High Pressure Liquid ; Cordocentesis ; Diseases of red blood cells ; Female ; Fetal Diseases - blood ; Fetal Diseases - diagnostic imaging ; Fetal Diseases - physiopathology ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Hb Bart's disease ; Hematologic and hematopoietic diseases ; Hemoglobins, Abnormal ; homozygous α‐thalassemia‐1 ; Humans ; MCA‐PSV ; Medical sciences ; Middle Cerebral Artery - diagnostic imaging ; Middle Cerebral Artery - embryology ; Middle Cerebral Artery - physiopathology ; middle cerebral artery peak systolic velocity ; Pregnancy ; Risk Factors ; Sensitivity and Specificity ; Ultrasonography, Prenatal - methods</subject><ispartof>Ultrasound in obstetrics & gynecology, 2009-06, Vol.33 (6), p.694-697</ispartof><rights>Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.</rights><rights>2009 INIST-CNRS</rights><rights>(c) 2009 ISUOG.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4152-e57ff6d22f7582d510ca4e61066d5933abaff81cc0aae759c383dedd388b223c3</citedby><cites>FETCH-LOGICAL-c4152-e57ff6d22f7582d510ca4e61066d5933abaff81cc0aae759c383dedd388b223c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fuog.6342$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fuog.6342$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21519466$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19350531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Srisupundit, K.</creatorcontrib><creatorcontrib>Piyamongkol, W.</creatorcontrib><creatorcontrib>Tongsong, T.</creatorcontrib><title>Identification of fetuses with hemoglobin Bart's disease using middle cerebral artery peak systolic velocity</title><title>Ultrasound in obstetrics & gynecology</title><addtitle>Ultrasound Obstet Gynecol</addtitle><description>Objectives
To determine the sensitivity and specificity of middle cerebral artery peak systolic velocity (MCA‐PSV) in mid‐pregnancy for the identification of homozygous α‐thalassemia‐1 (hemoglobin (Hb) Bart's disease) in fetuses at risk of the disease.
Methods
A total of 88 pregnancies (91 fetuses) at risk of Hb Bart's disease and undergoing MCA‐PSV measurement before cordocentesis at 18–22 weeks of gestation were recruited into the study. Definitive diagnosis was made using the gold standard technique of Hb typing by high‐performance liquid chromatography.
Results
The mean ± SD age of the 88 pregnant women recruited into the study was 28.3 ± 5.7 years, the gestational age was 18.8 ± 1.1 weeks and the incidence of Hb Bart's disease was 22% (20 fetuses). Using MCA‐PSV above 1.5 multiples of the median as a cut‐off point, the sensitivity of MCA‐PSV for detecting affected fetuses was 85% (17/20 cases), with a specificity of 100%, and positive and negative predictive values of 100% and 95.9% respectively. Three of 20 fetuses with Hb Bart's disease had normal MCA‐PSV.
Conclusions
MCA‐PSV assessment in mid‐pregnancy is a useful method for identifying Hb Bart's disease with high sensitivity and specificity among fetuses at risk, and may allow avoidance of unnecessary cordocentesis in some cases. Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>alpha-Thalassemia - blood</subject><subject>alpha-Thalassemia - diagnostic imaging</subject><subject>alpha-Thalassemia - physiopathology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - physiology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cordocentesis</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Fetal Diseases - blood</subject><subject>Fetal Diseases - diagnostic imaging</subject><subject>Fetal Diseases - physiopathology</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hb Bart's disease</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobins, Abnormal</subject><subject>homozygous α‐thalassemia‐1</subject><subject>Humans</subject><subject>MCA‐PSV</subject><subject>Medical sciences</subject><subject>Middle Cerebral Artery - diagnostic imaging</subject><subject>Middle Cerebral Artery - embryology</subject><subject>Middle Cerebral Artery - physiopathology</subject><subject>middle cerebral artery peak systolic velocity</subject><subject>Pregnancy</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonography, Prenatal - methods</subject><issn>0960-7692</issn><issn>1469-0705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90UFv1DAQBWALgehSkPgFyBcol5SxHTvJsVRQKlXqhZ4jxx5vDd548SRU-fek7ApOcJrLp_ekeYy9FnAuAOSHOW_PjarlE7YRtekqaEA_ZRvoDFSN6eQJe0H0DQBMrcxzdiI6pUErsWHp2uM4xRCdnWIeeQ484DQTEn-I0z2_x13epjzEkX-0ZToj7iOhJeQzxXHLd9H7hNxhwaHYxFeDZeF7tN85LTTlFB3_iSm7OC0v2bNgE-Gr4z1ld58_fb38Ut3cXl1fXtxUrhZaVqibEIyXMjS6lV4LcLZGI8AYrzul7GBDaIVzYC02unOqVR69V207SKmcOmVnh9x9yT9mpKnfRXKYkh0xz9Q3SkkJrVKrfPdfKQEaKZt6he8P0JVMVDD0-xJ3tiy9gP5xg37doH_cYKVvjpnzsEP_Fx6fvoK3R2DJ2RSKHV2kP04KLbramNVVB_cQEy7_LOzvbq9-F_8CYASemA</recordid><startdate>200906</startdate><enddate>200906</enddate><creator>Srisupundit, K.</creator><creator>Piyamongkol, W.</creator><creator>Tongsong, T.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200906</creationdate><title>Identification of fetuses with hemoglobin Bart's disease using middle cerebral artery peak systolic velocity</title><author>Srisupundit, K. ; Piyamongkol, W. ; Tongsong, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4152-e57ff6d22f7582d510ca4e61066d5933abaff81cc0aae759c383dedd388b223c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>alpha-Thalassemia - blood</topic><topic>alpha-Thalassemia - diagnostic imaging</topic><topic>alpha-Thalassemia - physiopathology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - physiology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cordocentesis</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>Fetal Diseases - blood</topic><topic>Fetal Diseases - diagnostic imaging</topic><topic>Fetal Diseases - physiopathology</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hb Bart's disease</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobins, Abnormal</topic><topic>homozygous α‐thalassemia‐1</topic><topic>Humans</topic><topic>MCA‐PSV</topic><topic>Medical sciences</topic><topic>Middle Cerebral Artery - diagnostic imaging</topic><topic>Middle Cerebral Artery - embryology</topic><topic>Middle Cerebral Artery - physiopathology</topic><topic>middle cerebral artery peak systolic velocity</topic><topic>Pregnancy</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonography, Prenatal - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Srisupundit, K.</creatorcontrib><creatorcontrib>Piyamongkol, W.</creatorcontrib><creatorcontrib>Tongsong, T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Srisupundit, K.</au><au>Piyamongkol, W.</au><au>Tongsong, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of fetuses with hemoglobin Bart's disease using middle cerebral artery peak systolic velocity</atitle><jtitle>Ultrasound in obstetrics & gynecology</jtitle><addtitle>Ultrasound Obstet Gynecol</addtitle><date>2009-06</date><risdate>2009</risdate><volume>33</volume><issue>6</issue><spage>694</spage><epage>697</epage><pages>694-697</pages><issn>0960-7692</issn><eissn>1469-0705</eissn><abstract>Objectives
To determine the sensitivity and specificity of middle cerebral artery peak systolic velocity (MCA‐PSV) in mid‐pregnancy for the identification of homozygous α‐thalassemia‐1 (hemoglobin (Hb) Bart's disease) in fetuses at risk of the disease.
Methods
A total of 88 pregnancies (91 fetuses) at risk of Hb Bart's disease and undergoing MCA‐PSV measurement before cordocentesis at 18–22 weeks of gestation were recruited into the study. Definitive diagnosis was made using the gold standard technique of Hb typing by high‐performance liquid chromatography.
Results
The mean ± SD age of the 88 pregnant women recruited into the study was 28.3 ± 5.7 years, the gestational age was 18.8 ± 1.1 weeks and the incidence of Hb Bart's disease was 22% (20 fetuses). Using MCA‐PSV above 1.5 multiples of the median as a cut‐off point, the sensitivity of MCA‐PSV for detecting affected fetuses was 85% (17/20 cases), with a specificity of 100%, and positive and negative predictive values of 100% and 95.9% respectively. Three of 20 fetuses with Hb Bart's disease had normal MCA‐PSV.
Conclusions
MCA‐PSV assessment in mid‐pregnancy is a useful method for identifying Hb Bart's disease with high sensitivity and specificity among fetuses at risk, and may allow avoidance of unnecessary cordocentesis in some cases. Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19350531</pmid><doi>10.1002/uog.6342</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0960-7692 |
| ispartof | Ultrasound in obstetrics & gynecology, 2009-06, Vol.33 (6), p.694-697 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content |
| subjects | Adult alpha-Thalassemia - blood alpha-Thalassemia - diagnostic imaging alpha-Thalassemia - physiopathology Anemias. Hemoglobinopathies Biological and medical sciences Blood Flow Velocity - physiology Chromatography, High Pressure Liquid Cordocentesis Diseases of red blood cells Female Fetal Diseases - blood Fetal Diseases - diagnostic imaging Fetal Diseases - physiopathology Gestational Age Gynecology. Andrology. Obstetrics Hb Bart's disease Hematologic and hematopoietic diseases Hemoglobins, Abnormal homozygous α‐thalassemia‐1 Humans MCA‐PSV Medical sciences Middle Cerebral Artery - diagnostic imaging Middle Cerebral Artery - embryology Middle Cerebral Artery - physiopathology middle cerebral artery peak systolic velocity Pregnancy Risk Factors Sensitivity and Specificity Ultrasonography, Prenatal - methods |
| title | Identification of fetuses with hemoglobin Bart's disease using middle cerebral artery peak systolic velocity |
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