Vascularization—The Conduit to Viable Engineered Tissues
Long-term viability of thick three-dimensional engineered tissue constructs is a major challenge. Addressing it requires development of vessel-like network that will allow the survival of the construct in vitro and its integration in vivo owing to improved vascularization after implantation. Resulti...
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| Veröffentlicht in: | Tissue engineering. Part B, Reviews Reviews, 2009-06, Vol.15 (2), p.159-169 |
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| container_title | Tissue engineering. Part B, Reviews |
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| creator | Kaully, Tamar Kaufman-Francis, Keren Lesman, Ayelet Levenberg, Shulamit |
| description | Long-term viability of thick three-dimensional engineered tissue constructs is a major challenge. Addressing it requires development of vessel-like network that will allow the survival of the construct
in vitro
and its integration
in vivo
owing to improved vascularization after implantation. Resulting from work of various research groups, several approaches were developed aiming engineered tissue vascularization: (1) embodiment of angiogenesis growth factors in the polymeric scaffolds for prolonged release, (2) coculture of endothelial cells with target tissue cells and angiogenesis signaling cells, (3) use of microfabrication methods for creating designed channels for allowing nutrients to flow and/or for directing endothelial cells attachment, and (4) decellularization of organs and blood vessels for creating extracellular matrix. A synergistic effect is expected by combining several of these approaches as already demonstrated in some of the latest studies. Current paper reviews the progress in each approach and recent achievements toward vascularization of engineered tissues. |
| doi_str_mv | 10.1089/ten.teb.2008.0193 |
| format | Article |
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in vitro
and its integration
in vivo
owing to improved vascularization after implantation. Resulting from work of various research groups, several approaches were developed aiming engineered tissue vascularization: (1) embodiment of angiogenesis growth factors in the polymeric scaffolds for prolonged release, (2) coculture of endothelial cells with target tissue cells and angiogenesis signaling cells, (3) use of microfabrication methods for creating designed channels for allowing nutrients to flow and/or for directing endothelial cells attachment, and (4) decellularization of organs and blood vessels for creating extracellular matrix. A synergistic effect is expected by combining several of these approaches as already demonstrated in some of the latest studies. Current paper reviews the progress in each approach and recent achievements toward vascularization of engineered tissues.</description><identifier>ISSN: 1937-3368</identifier><identifier>EISSN: 1937-3376</identifier><identifier>DOI: 10.1089/ten.teb.2008.0193</identifier><identifier>PMID: 19309238</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animals ; Blood Vessels - physiology ; Cell culture ; Cellular biology ; Coculture Techniques ; Extracellular matrix ; Humans ; Integrated approach ; Intercellular Signaling Peptides and Proteins - secretion ; Methods ; Neovascularization, Physiologic ; Physiological aspects ; Tissue engineering ; Tissue Engineering - methods ; Tissue Scaffolds - chemistry ; Veins & arteries</subject><ispartof>Tissue engineering. Part B, Reviews, 2009-06, Vol.15 (2), p.159-169</ispartof><rights>2009, Mary Ann Liebert, Inc.</rights><rights>COPYRIGHT 2009 Mary Ann Liebert, Inc.</rights><rights>(©) Copyright 2009, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-2e83dbc3ae6dd88573d893a7c02d484fa37cb76d17dec1ebae2af63607b8fee83</citedby><cites>FETCH-LOGICAL-c539t-2e83dbc3ae6dd88573d893a7c02d484fa37cb76d17dec1ebae2af63607b8fee83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/ten.teb.2008.0193$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/ten.teb.2008.0193$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>314,777,781,3029,21704,27905,27906,55272,55284</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19309238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaully, Tamar</creatorcontrib><creatorcontrib>Kaufman-Francis, Keren</creatorcontrib><creatorcontrib>Lesman, Ayelet</creatorcontrib><creatorcontrib>Levenberg, Shulamit</creatorcontrib><title>Vascularization—The Conduit to Viable Engineered Tissues</title><title>Tissue engineering. Part B, Reviews</title><addtitle>Tissue Eng Part B Rev</addtitle><description>Long-term viability of thick three-dimensional engineered tissue constructs is a major challenge. Addressing it requires development of vessel-like network that will allow the survival of the construct
in vitro
and its integration
in vivo
owing to improved vascularization after implantation. Resulting from work of various research groups, several approaches were developed aiming engineered tissue vascularization: (1) embodiment of angiogenesis growth factors in the polymeric scaffolds for prolonged release, (2) coculture of endothelial cells with target tissue cells and angiogenesis signaling cells, (3) use of microfabrication methods for creating designed channels for allowing nutrients to flow and/or for directing endothelial cells attachment, and (4) decellularization of organs and blood vessels for creating extracellular matrix. A synergistic effect is expected by combining several of these approaches as already demonstrated in some of the latest studies. Current paper reviews the progress in each approach and recent achievements toward vascularization of engineered tissues.</description><subject>Animals</subject><subject>Blood Vessels - physiology</subject><subject>Cell culture</subject><subject>Cellular biology</subject><subject>Coculture Techniques</subject><subject>Extracellular matrix</subject><subject>Humans</subject><subject>Integrated approach</subject><subject>Intercellular Signaling Peptides and Proteins - secretion</subject><subject>Methods</subject><subject>Neovascularization, Physiologic</subject><subject>Physiological aspects</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Veins & arteries</subject><issn>1937-3368</issn><issn>1937-3376</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc2OFCEQx4nRuOvqA3gxHU30NG0Bs0B720zWj2QTL-NeCR_VK5seWIE-6MmH8An3SZbOTDQaYwyBIsXvXxT8CXlKoaeghtcVY1_R9gxA9UAHfo8ct1WuOJfi_s-9UEfkUSnXAAKEVA_JUTuAgXF1TN5cmuLmyeTwzdSQ4u33H9vP2G1S9HOoXU3dZTB2wu48XoWImNF321DKjOUxeTCaqeCTQzwhn96ebzfvVxcf333YnF2s3Ckf6oqh4t46blB4r9Sp5F4N3EgHzK_VejRcOiuFp9Kjo2gNMjMKLkBaNWITn5BX-7o3OX1p91a9C8XhNJmIaS5acs4YKAaNfPlPkoEYKB3WDXz-B3id5hzbKxrD28eA4g16sYeuzIQ6xDHVbNxSUZ8xkJRyyZfu-r9QbXjcBZcijqHlfxPQvcDlVErGUd_ksDP5q6agF1t1s7VNqxdb9WJr0zw79DvbHfpfioOPDZB7YEmbGKeAFnP9j9J3fRGxBA</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Kaully, Tamar</creator><creator>Kaufman-Francis, Keren</creator><creator>Lesman, Ayelet</creator><creator>Levenberg, Shulamit</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Vascularization—The Conduit to Viable Engineered Tissues</title><author>Kaully, Tamar ; 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Part B, Reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaully, Tamar</au><au>Kaufman-Francis, Keren</au><au>Lesman, Ayelet</au><au>Levenberg, Shulamit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascularization—The Conduit to Viable Engineered Tissues</atitle><jtitle>Tissue engineering. Part B, Reviews</jtitle><addtitle>Tissue Eng Part B Rev</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>15</volume><issue>2</issue><spage>159</spage><epage>169</epage><pages>159-169</pages><issn>1937-3368</issn><eissn>1937-3376</eissn><abstract>Long-term viability of thick three-dimensional engineered tissue constructs is a major challenge. Addressing it requires development of vessel-like network that will allow the survival of the construct
in vitro
and its integration
in vivo
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| identifier | ISSN: 1937-3368 |
| ispartof | Tissue engineering. Part B, Reviews, 2009-06, Vol.15 (2), p.159-169 |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Blood Vessels - physiology Cell culture Cellular biology Coculture Techniques Extracellular matrix Humans Integrated approach Intercellular Signaling Peptides and Proteins - secretion Methods Neovascularization, Physiologic Physiological aspects Tissue engineering Tissue Engineering - methods Tissue Scaffolds - chemistry Veins & arteries |
| title | Vascularization—The Conduit to Viable Engineered Tissues |
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