Role of viral receptors TLR3, RIG-I and MDA5 in mesothelial tissue-type plasminogen activator and plasminogen activator inhibitor-1 synthesis

Summary Tissue-type plasminogen activator (t-PA) and its specific inhibitor plasminogen activator inhibitor-1 (PAI-1) are key mediators in the regulation of fibrin generation and fibrinolysis. Mesothelial cells (MC) line the inner surface of serosal cavities and are a source of procoagulant and fibr...

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Veröffentlicht in:	Thrombosis and haemostasis 2009-06, Vol.101 (6), p.1128-1137
Hauptverfasser:	Wörnle, Markus, Sauter, Matthias, Kastenmüller, Kathrin, Ribeiro, Andrea, Mussack, Thomas, Ladurner, Roland, Sitter, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured DEAD Box Protein 58 DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - immunology DEAD-box RNA Helicases - metabolism Epithelium - metabolism Epithelium - pathology Epithelium - virology Feedback, Physiological Fibrin - metabolism Fibrinolysis - immunology Humans Immunity, Innate Interferon-Induced Helicase, IFIH1 MDA5 Mesothelial PAI-1 Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - immunology Plasminogen Activator Inhibitor 1 - metabolism Receptors, Immunologic RIG-I RNA, Small Interfering - genetics RNA, Viral - immunology RNA, Viral - metabolism Serous Membrane - pathology Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - immunology Tissue Plasminogen Activator - metabolism Toll-like receptor 3 Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - immunology Toll-Like Receptor 3 - metabolism Wound Healing and Inflammation/Infection
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