Biochemical and pharmacological effects of the direct thrombin inhibitor AR-H067637

Summary AZD0837 is in development as a new oral anticoagulant for use in thromboembolic disorders. In vivo , AZD0837 is converted to AR-H067637, a selective and reversible direct thrombin inhibitor. Established biochemical methods were used to assess and measure the biochemical and pharmacological p...

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Veröffentlicht in:	Thrombosis and haemostasis 2009-06, Vol.101 (6), p.1051-1059
Hauptverfasser:	Deinum, Johanna, Mattsson, Christer, Inghardt, Tord, Elg, Margareta
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidines - pharmacokinetics Amidines - pharmacology Anticoagulants - pharmacology Azetidines - pharmacokinetics Azetidines - pharmacology Biacore Binding, Competitive Biological and medical sciences Blood Coagulation - drug effects Blood Coagulation Factors - metabolism Blood Coagulation, Fibrinolysis and Cellular Haemostasis Blood coagulation. Blood cells Blood Platelets - enzymology Dose-Response Relationship, Drug Drug Evaluation, Preclinical enzyme kinetics Female Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Humans Inhibitory Concentration 50 Male Medical sciences Molecular and cellular biology plasma coagulation Platelet Activation - drug effects Platelet diseases and coagulopathies Protein Binding Thrombin - antagonists & inhibitors thrombin inhibitor Whole Blood Coagulation Time
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