Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes

The Na(+)/Ca(2+) exchanger (NCX1) plays a key role in maintaining Ca(2+) homeostasis in cardiomyocytes. Disruption of Ncx1 gene in mice results in embryonic lethality between embryonic day 9 and 10, with the mice lacking spontaneous heartbeats. We examined the mechanism of lack of heartbeats in Ncx1...

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Veröffentlicht in:	Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2003-05, Vol.135 (1), p.9-15
Hauptverfasser:	Wakimoto, Koji, Fujimura, Hisako, Iwamoto, Takahiro, Oka, Toru, Kobayashi, Kinji, Kita, Satomi, Kudoh, Sumiyo, Kuro-o, Makoto, Nabeshima, Yo ichi, Shigekawa, Munekazu, Imai, Yuji, Komuro, Issei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Brain - metabolism Cells, Cultured Embryo, Mammalian Gene Expression Regulation Heart Kidney - metabolism Mice Mice, Knockout Mitochondria - metabolism Mitochondria - ultrastructure Myocytes, Cardiac - chemistry Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Myofibrils - chemistry Myofibrils - metabolism Myofibrils - ultrastructure Reverse Transcriptase Polymerase Chain Reaction Sodium-Calcium Exchanger - analysis Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - physiology
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