Successful treatment of a patient with subcutaneous panniculitis‐like T‐cell lymphoma with high‐dose chemotherapy and total body irradiation
: A 24‐yr‐old man was referred for fever, right cheek swelling, subcutaneous tumor and liver dysfunction. Physical examination showed an elastic hard subcutaneous tumor on the right cheek, left axillary lymph node swelling and multiple small subcutaneous tumors in the trunk. Laboratory examinations...
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| Veröffentlicht in: | European journal of haematology 2003-06, Vol.70 (6), p.413-416 |
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| container_title | European journal of haematology |
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| creator | Mukai, Harumi Y. Okoshi, Yasushi Shimizu, Seiichi Katsura, Yukitaka Takei, Naoko Hasegawa, Yuichi Kojima, Hiroshi Mori, Naoyoshi Nagasawa, Toshiro |
| description | : A 24‐yr‐old man was referred for fever, right cheek swelling, subcutaneous tumor and liver dysfunction. Physical examination showed an elastic hard subcutaneous tumor on the right cheek, left axillary lymph node swelling and multiple small subcutaneous tumors in the trunk. Laboratory examinations showed elevated levels of transaminase, soluble interleukin‐2 receptor and ferritin. Biopsy of the subcutaneous tumor showed proliferation of medium‐sized cells with abundant clear cytoplasm and hyperchromatic nuclei among the subcutaneous fat tissues. These cells showed CD3+, CD4−, CD8+, CD56− and CD20− phenotype and possessed cytotoxic molecules such as granzyme B and T‐cell intracellular antigen‐1. Bone marrow aspiration showed proliferation of small numbers of abnormal lymphocytes with severe hemophagocytosis. He was thus diagnosed as having subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) and treated with dose‐escalated CHOP regimen. After three courses of the chemotherapy, he was further treated with high‐dose chemotherapy and total body irradiation (TBI) with autologous peripheral blood stem cell rescue. Thereafter, he has been in remission for more than 2 yr. We consider that SPTCL with hemophagocytosis is an extremely aggressive disease, and high‐dose chemotherapy and TBI should be included for the choice of the treatment. |
| doi_str_mv | 10.1034/j.1600-0609.2003.00058.x |
| format | Article |
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Physical examination showed an elastic hard subcutaneous tumor on the right cheek, left axillary lymph node swelling and multiple small subcutaneous tumors in the trunk. Laboratory examinations showed elevated levels of transaminase, soluble interleukin‐2 receptor and ferritin. Biopsy of the subcutaneous tumor showed proliferation of medium‐sized cells with abundant clear cytoplasm and hyperchromatic nuclei among the subcutaneous fat tissues. These cells showed CD3+, CD4−, CD8+, CD56− and CD20− phenotype and possessed cytotoxic molecules such as granzyme B and T‐cell intracellular antigen‐1. Bone marrow aspiration showed proliferation of small numbers of abnormal lymphocytes with severe hemophagocytosis. He was thus diagnosed as having subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) and treated with dose‐escalated CHOP regimen. After three courses of the chemotherapy, he was further treated with high‐dose chemotherapy and total body irradiation (TBI) with autologous peripheral blood stem cell rescue. Thereafter, he has been in remission for more than 2 yr. We consider that SPTCL with hemophagocytosis is an extremely aggressive disease, and high‐dose chemotherapy and TBI should be included for the choice of the treatment.</description><identifier>ISSN: 0902-4441</identifier><identifier>EISSN: 1600-0609</identifier><identifier>DOI: 10.1034/j.1600-0609.2003.00058.x</identifier><identifier>PMID: 12756026</identifier><identifier>CODEN: EJHAEC</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adult ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Bone Marrow Examination ; Dermatology ; Hematologic and hematopoietic diseases ; hemophagocytic syndrome ; high‐dose chemotherapy ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, T-Cell, Peripheral - diagnosis ; Lymphoma, T-Cell, Peripheral - therapy ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Neoplasm, Residual - diagnosis ; Panniculitis ; Peripheral Blood Stem Cell Transplantation ; Remission Induction - methods ; Skin involvement in other diseases. Miscellaneous. General aspects ; stem cell rescue ; subcutaneous panniculitis‐like T‐cell lymphoma ; Subcutaneous Tissue - pathology ; total body irradiation ; Whole-Body Irradiation</subject><ispartof>European journal of haematology, 2003-06, Vol.70 (6), p.413-416</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3948-ca88d02ceae38135b5bb2230f64d3a5b59ba58393d54cbf20fdb05b4ca0bb1883</citedby><cites>FETCH-LOGICAL-c3948-ca88d02ceae38135b5bb2230f64d3a5b59ba58393d54cbf20fdb05b4ca0bb1883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0609.2003.00058.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14769324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12756026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mukai, Harumi Y.</creatorcontrib><creatorcontrib>Okoshi, Yasushi</creatorcontrib><creatorcontrib>Shimizu, Seiichi</creatorcontrib><creatorcontrib>Katsura, Yukitaka</creatorcontrib><creatorcontrib>Takei, Naoko</creatorcontrib><creatorcontrib>Hasegawa, Yuichi</creatorcontrib><creatorcontrib>Kojima, Hiroshi</creatorcontrib><creatorcontrib>Mori, Naoyoshi</creatorcontrib><creatorcontrib>Nagasawa, Toshiro</creatorcontrib><title>Successful treatment of a patient with subcutaneous panniculitis‐like T‐cell lymphoma with high‐dose chemotherapy and total body irradiation</title><title>European journal of haematology</title><addtitle>Eur J Haematol</addtitle><description>: A 24‐yr‐old man was referred for fever, right cheek swelling, subcutaneous tumor and liver dysfunction. Physical examination showed an elastic hard subcutaneous tumor on the right cheek, left axillary lymph node swelling and multiple small subcutaneous tumors in the trunk. Laboratory examinations showed elevated levels of transaminase, soluble interleukin‐2 receptor and ferritin. Biopsy of the subcutaneous tumor showed proliferation of medium‐sized cells with abundant clear cytoplasm and hyperchromatic nuclei among the subcutaneous fat tissues. These cells showed CD3+, CD4−, CD8+, CD56− and CD20− phenotype and possessed cytotoxic molecules such as granzyme B and T‐cell intracellular antigen‐1. Bone marrow aspiration showed proliferation of small numbers of abnormal lymphocytes with severe hemophagocytosis. He was thus diagnosed as having subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) and treated with dose‐escalated CHOP regimen. After three courses of the chemotherapy, he was further treated with high‐dose chemotherapy and total body irradiation (TBI) with autologous peripheral blood stem cell rescue. Thereafter, he has been in remission for more than 2 yr. We consider that SPTCL with hemophagocytosis is an extremely aggressive disease, and high‐dose chemotherapy and TBI should be included for the choice of the treatment.</description><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Examination</subject><subject>Dermatology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>hemophagocytic syndrome</subject><subject>high‐dose chemotherapy</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, T-Cell, Peripheral - diagnosis</subject><subject>Lymphoma, T-Cell, Peripheral - therapy</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm, Residual - diagnosis</subject><subject>Panniculitis</subject><subject>Peripheral Blood Stem Cell Transplantation</subject><subject>Remission Induction - methods</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>stem cell rescue</subject><subject>subcutaneous panniculitis‐like T‐cell lymphoma</subject><subject>Subcutaneous Tissue - pathology</subject><subject>total body irradiation</subject><subject>Whole-Body Irradiation</subject><issn>0902-4441</issn><issn>1600-0609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxi0EokvhFZAvcEuY2E7WkbigqqWgShwoZ8t2HOLFiRfbUZsbj4B4RJ4Eh6zolZNn9P3G8-dDCFdQVkDZm0NZNQAFNNCWBICWAFDz8v4R2v0THqMdtEAKxlh1hp7FeMgQaav9U3RWkX3dAGl26NfnWWsTYz87nIKRaTRTwr7HEh9lsmtyZ9OA46z0nORk_ByzMk1Wz84mG3__-OnsN4Nvc6CNc9gt43Hwo9zqBvt1yErno8F6MKNPgwnyuGA5dTj5JB1WvluwDUF2Nnf003P0pJcumhen9xx9ubq8vbgubj69_3Dx7qbQtGW80JLzDog20lBe0VrVShFCoW9YR2VOWyVrTlva1UyrnkDfKagV0xKUqjin5-j19u8x-O-ziUmMNq4rbFuKPaUEOLAM8g3UwccYTC-OwY4yLKICsfohDmI9u1jPLlY_xF8_xH0ufXnqMavRdA-FJwMy8OoEyKil64OctI0PHNs3LSXrDG837s46s_z3AOLy43UO6B99Cqzr</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Mukai, Harumi Y.</creator><creator>Okoshi, Yasushi</creator><creator>Shimizu, Seiichi</creator><creator>Katsura, Yukitaka</creator><creator>Takei, Naoko</creator><creator>Hasegawa, Yuichi</creator><creator>Kojima, Hiroshi</creator><creator>Mori, Naoyoshi</creator><creator>Nagasawa, Toshiro</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Successful treatment of a patient with subcutaneous panniculitis‐like T‐cell lymphoma with high‐dose chemotherapy and total body irradiation</title><author>Mukai, Harumi Y. ; Okoshi, Yasushi ; Shimizu, Seiichi ; Katsura, Yukitaka ; Takei, Naoko ; Hasegawa, Yuichi ; Kojima, Hiroshi ; Mori, Naoyoshi ; Nagasawa, Toshiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3948-ca88d02ceae38135b5bb2230f64d3a5b59ba58393d54cbf20fdb05b4ca0bb1883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Examination</topic><topic>Dermatology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>hemophagocytic syndrome</topic><topic>high‐dose chemotherapy</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, T-Cell, Peripheral - diagnosis</topic><topic>Lymphoma, T-Cell, Peripheral - therapy</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasm, Residual - diagnosis</topic><topic>Panniculitis</topic><topic>Peripheral Blood Stem Cell Transplantation</topic><topic>Remission Induction - methods</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>stem cell rescue</topic><topic>subcutaneous panniculitis‐like T‐cell lymphoma</topic><topic>Subcutaneous Tissue - pathology</topic><topic>total body irradiation</topic><topic>Whole-Body Irradiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mukai, Harumi Y.</creatorcontrib><creatorcontrib>Okoshi, Yasushi</creatorcontrib><creatorcontrib>Shimizu, Seiichi</creatorcontrib><creatorcontrib>Katsura, Yukitaka</creatorcontrib><creatorcontrib>Takei, Naoko</creatorcontrib><creatorcontrib>Hasegawa, Yuichi</creatorcontrib><creatorcontrib>Kojima, Hiroshi</creatorcontrib><creatorcontrib>Mori, Naoyoshi</creatorcontrib><creatorcontrib>Nagasawa, Toshiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mukai, Harumi Y.</au><au>Okoshi, Yasushi</au><au>Shimizu, Seiichi</au><au>Katsura, Yukitaka</au><au>Takei, Naoko</au><au>Hasegawa, Yuichi</au><au>Kojima, Hiroshi</au><au>Mori, Naoyoshi</au><au>Nagasawa, Toshiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of a patient with subcutaneous panniculitis‐like T‐cell lymphoma with high‐dose chemotherapy and total body irradiation</atitle><jtitle>European journal of haematology</jtitle><addtitle>Eur J Haematol</addtitle><date>2003-06</date><risdate>2003</risdate><volume>70</volume><issue>6</issue><spage>413</spage><epage>416</epage><pages>413-416</pages><issn>0902-4441</issn><eissn>1600-0609</eissn><coden>EJHAEC</coden><abstract>: A 24‐yr‐old man was referred for fever, right cheek swelling, subcutaneous tumor and liver dysfunction. Physical examination showed an elastic hard subcutaneous tumor on the right cheek, left axillary lymph node swelling and multiple small subcutaneous tumors in the trunk. Laboratory examinations showed elevated levels of transaminase, soluble interleukin‐2 receptor and ferritin. Biopsy of the subcutaneous tumor showed proliferation of medium‐sized cells with abundant clear cytoplasm and hyperchromatic nuclei among the subcutaneous fat tissues. These cells showed CD3+, CD4−, CD8+, CD56− and CD20− phenotype and possessed cytotoxic molecules such as granzyme B and T‐cell intracellular antigen‐1. Bone marrow aspiration showed proliferation of small numbers of abnormal lymphocytes with severe hemophagocytosis. He was thus diagnosed as having subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) and treated with dose‐escalated CHOP regimen. After three courses of the chemotherapy, he was further treated with high‐dose chemotherapy and total body irradiation (TBI) with autologous peripheral blood stem cell rescue. Thereafter, he has been in remission for more than 2 yr. We consider that SPTCL with hemophagocytosis is an extremely aggressive disease, and high‐dose chemotherapy and TBI should be included for the choice of the treatment.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>12756026</pmid><doi>10.1034/j.1600-0609.2003.00058.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Bone Marrow Examination Dermatology Hematologic and hematopoietic diseases hemophagocytic syndrome high‐dose chemotherapy Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, T-Cell, Peripheral - diagnosis Lymphoma, T-Cell, Peripheral - therapy Magnetic Resonance Imaging Male Medical sciences Neoplasm, Residual - diagnosis Panniculitis Peripheral Blood Stem Cell Transplantation Remission Induction - methods Skin involvement in other diseases. Miscellaneous. General aspects stem cell rescue subcutaneous panniculitis‐like T‐cell lymphoma Subcutaneous Tissue - pathology total body irradiation Whole-Body Irradiation |
| title | Successful treatment of a patient with subcutaneous panniculitis‐like T‐cell lymphoma with high‐dose chemotherapy and total body irradiation |
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