White blood cells as a novel mortality predictor in haemodialysis patients
Background. Many conventional cardiovascular risk factors in the general population are not as predictive in end‐stage renal disease (ESRD). As absolute neutrophil count and total white blood cell (WBC) count are associated with adverse cardiovascular outcomes and all‐cause mortality, this analysis...
Gespeichert in:
| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2003-06, Vol.18 (6), p.1167-1173 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1173 |
|---|---|
| container_issue | 6 |
| container_start_page | 1167 |
| container_title | Nephrology, dialysis, transplantation |
| container_volume | 18 |
| creator | Reddan, Donal N. Klassen, Preston S. Szczech, Lynda A. Coladonato, Joseph A. O'Shea, Susan Owen Jr, William F. Lowrie, Edmund G. |
| description | Background. Many conventional cardiovascular risk factors in the general population are not as predictive in end‐stage renal disease (ESRD). As absolute neutrophil count and total white blood cell (WBC) count are associated with adverse cardiovascular outcomes and all‐cause mortality, this analysis was undertaken to explore the associations of WBC variables with mortality risk in ESRD. Methods. Of a total study population of 44 114 ESRD patients receiving haemodialysis during 1998 at facilities operated by Fresenius Medical Care, North America, 25 661 patients who underwent differential white cell count and had complete follow‐up were included. Information on case mix (age, gender, race), clinical (diabetes, body mass index), and laboratory variables (haematocrit, albumin, creatinine, potassium, calcium, phosphorus, bicarbonate, ferritin, transferrin saturation and differential WBC count) was obtained. Associations between lymphocyte count, neutrophil count and demographic and clinical variables were examined using linear regression. Associations between WBC variables and survival were estimated using Cox proportional hazard regression. Results. A higher lymphocyte count was associated with higher serum albumin and creatinine, lower age and black race. High neutrophil count was associated with lower serum albumin and creatinine, younger age and white race (all Ps |
| doi_str_mv | 10.1093/ndt/gfg066 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73320663</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73320663</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-dbbdd36d02f2d2769c4c523e1a99ee0f90d9af9100c11bf4168c7ff7ce67a1db3</originalsourceid><addsrcrecordid>eNpFkMtKxDAUhoMoOl42PoBkowuhetK0TbOU8a6gC2-4CWkuGm2bMcmI8_Z2mEHhwFn8H_85fAjtEjgiwOlxr9Pxm32DqlpBI1JUkOW0LlfRaAhJBiXwDbQZ4wcA8JyxdbRBclbUtCQjdP387pLBTeu9xsq0bcRyGNz7b9PizockW5dmeBKMdir5gF2P36XpvHaynUUX8UQmZ_oUt9GalW00O8u9hR7Pzx7Gl9nt3cXV-OQ2U7RmKdNNozWtNOQ21zmruCpUmVNDJOfGgOWgubScAChCGluQqlbMWqZMxSTRDd1CB4veSfBfUxOT6Fycvy5746dRMErzwQUdwMMFqIKPMRgrJsF1MswEATE3JwZzYmFugPeWrdOmM_ofXaoagP0lIKOSrQ2yVy7-cwWnNeHzq9mCczGZn79chk9RMcpKcfnyKuD-4f7mFU7FE_0FzK-HvA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73320663</pqid></control><display><type>article</type><title>White blood cells as a novel mortality predictor in haemodialysis patients</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Reddan, Donal N. ; Klassen, Preston S. ; Szczech, Lynda A. ; Coladonato, Joseph A. ; O'Shea, Susan ; Owen Jr, William F. ; Lowrie, Edmund G.</creator><creatorcontrib>Reddan, Donal N. ; Klassen, Preston S. ; Szczech, Lynda A. ; Coladonato, Joseph A. ; O'Shea, Susan ; Owen Jr, William F. ; Lowrie, Edmund G.</creatorcontrib><description>Background. Many conventional cardiovascular risk factors in the general population are not as predictive in end‐stage renal disease (ESRD). As absolute neutrophil count and total white blood cell (WBC) count are associated with adverse cardiovascular outcomes and all‐cause mortality, this analysis was undertaken to explore the associations of WBC variables with mortality risk in ESRD. Methods. Of a total study population of 44 114 ESRD patients receiving haemodialysis during 1998 at facilities operated by Fresenius Medical Care, North America, 25 661 patients who underwent differential white cell count and had complete follow‐up were included. Information on case mix (age, gender, race), clinical (diabetes, body mass index), and laboratory variables (haematocrit, albumin, creatinine, potassium, calcium, phosphorus, bicarbonate, ferritin, transferrin saturation and differential WBC count) was obtained. Associations between lymphocyte count, neutrophil count and demographic and clinical variables were examined using linear regression. Associations between WBC variables and survival were estimated using Cox proportional hazard regression. Results. A higher lymphocyte count was associated with higher serum albumin and creatinine, lower age and black race. High neutrophil count was associated with lower serum albumin and creatinine, younger age and white race (all Ps <0.0001). Cox proportional hazard regression showed an increased lymphocyte count was associated with reduced mortality risk [HR 0.86 (0.83–0.89) per 500/ml increase in lymphocyte count] and an increased neutrophil count was associated with increased mortality risk [HR 1.08 (1.06–1.09) per 1000/ml increase in neutrophil count]. Conclusions. An increased neutrophil count is strongly associated with, and reduced lymphocyte count associated less strongly with, many surrogates of both malnutrition and inflammation. An increased neutrophil count and reduced lymphocyte count are independent predictors of increased mortality risk in haemodialysis patients.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfg066</identifier><identifier>PMID: 12748351</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Coronary Disease - immunology ; Coronary Disease - mortality ; Emergency and intensive care: renal failure. Dialysis management ; end‐stage renal disease ; Female ; Ferritins - metabolism ; haemodialysis ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - immunology ; Kidney Failure, Chronic - mortality ; Leukocyte Count ; Linear Models ; lymphocytes ; Lymphocytes - metabolism ; Male ; Medical sciences ; Middle Aged ; mortality ; neutrophils ; Neutrophils - metabolism ; Renal Dialysis ; Risk Factors</subject><ispartof>Nephrology, dialysis, transplantation, 2003-06, Vol.18 (6), p.1167-1173</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-dbbdd36d02f2d2769c4c523e1a99ee0f90d9af9100c11bf4168c7ff7ce67a1db3</citedby><cites>FETCH-LOGICAL-c387t-dbbdd36d02f2d2769c4c523e1a99ee0f90d9af9100c11bf4168c7ff7ce67a1db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14938193$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12748351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reddan, Donal N.</creatorcontrib><creatorcontrib>Klassen, Preston S.</creatorcontrib><creatorcontrib>Szczech, Lynda A.</creatorcontrib><creatorcontrib>Coladonato, Joseph A.</creatorcontrib><creatorcontrib>O'Shea, Susan</creatorcontrib><creatorcontrib>Owen Jr, William F.</creatorcontrib><creatorcontrib>Lowrie, Edmund G.</creatorcontrib><title>White blood cells as a novel mortality predictor in haemodialysis patients</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol. Dial. Transplant</addtitle><description>Background. Many conventional cardiovascular risk factors in the general population are not as predictive in end‐stage renal disease (ESRD). As absolute neutrophil count and total white blood cell (WBC) count are associated with adverse cardiovascular outcomes and all‐cause mortality, this analysis was undertaken to explore the associations of WBC variables with mortality risk in ESRD. Methods. Of a total study population of 44 114 ESRD patients receiving haemodialysis during 1998 at facilities operated by Fresenius Medical Care, North America, 25 661 patients who underwent differential white cell count and had complete follow‐up were included. Information on case mix (age, gender, race), clinical (diabetes, body mass index), and laboratory variables (haematocrit, albumin, creatinine, potassium, calcium, phosphorus, bicarbonate, ferritin, transferrin saturation and differential WBC count) was obtained. Associations between lymphocyte count, neutrophil count and demographic and clinical variables were examined using linear regression. Associations between WBC variables and survival were estimated using Cox proportional hazard regression. Results. A higher lymphocyte count was associated with higher serum albumin and creatinine, lower age and black race. High neutrophil count was associated with lower serum albumin and creatinine, younger age and white race (all Ps <0.0001). Cox proportional hazard regression showed an increased lymphocyte count was associated with reduced mortality risk [HR 0.86 (0.83–0.89) per 500/ml increase in lymphocyte count] and an increased neutrophil count was associated with increased mortality risk [HR 1.08 (1.06–1.09) per 1000/ml increase in neutrophil count]. Conclusions. An increased neutrophil count is strongly associated with, and reduced lymphocyte count associated less strongly with, many surrogates of both malnutrition and inflammation. An increased neutrophil count and reduced lymphocyte count are independent predictors of increased mortality risk in haemodialysis patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Coronary Disease - immunology</subject><subject>Coronary Disease - mortality</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>end‐stage renal disease</subject><subject>Female</subject><subject>Ferritins - metabolism</subject><subject>haemodialysis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - immunology</subject><subject>Kidney Failure, Chronic - mortality</subject><subject>Leukocyte Count</subject><subject>Linear Models</subject><subject>lymphocytes</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mortality</subject><subject>neutrophils</subject><subject>Neutrophils - metabolism</subject><subject>Renal Dialysis</subject><subject>Risk Factors</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtKxDAUhoMoOl42PoBkowuhetK0TbOU8a6gC2-4CWkuGm2bMcmI8_Z2mEHhwFn8H_85fAjtEjgiwOlxr9Pxm32DqlpBI1JUkOW0LlfRaAhJBiXwDbQZ4wcA8JyxdbRBclbUtCQjdP387pLBTeu9xsq0bcRyGNz7b9PizockW5dmeBKMdir5gF2P36XpvHaynUUX8UQmZ_oUt9GalW00O8u9hR7Pzx7Gl9nt3cXV-OQ2U7RmKdNNozWtNOQ21zmruCpUmVNDJOfGgOWgubScAChCGluQqlbMWqZMxSTRDd1CB4veSfBfUxOT6Fycvy5746dRMErzwQUdwMMFqIKPMRgrJsF1MswEATE3JwZzYmFugPeWrdOmM_ofXaoagP0lIKOSrQ2yVy7-cwWnNeHzq9mCczGZn79chk9RMcpKcfnyKuD-4f7mFU7FE_0FzK-HvA</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Reddan, Donal N.</creator><creator>Klassen, Preston S.</creator><creator>Szczech, Lynda A.</creator><creator>Coladonato, Joseph A.</creator><creator>O'Shea, Susan</creator><creator>Owen Jr, William F.</creator><creator>Lowrie, Edmund G.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>White blood cells as a novel mortality predictor in haemodialysis patients</title><author>Reddan, Donal N. ; Klassen, Preston S. ; Szczech, Lynda A. ; Coladonato, Joseph A. ; O'Shea, Susan ; Owen Jr, William F. ; Lowrie, Edmund G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-dbbdd36d02f2d2769c4c523e1a99ee0f90d9af9100c11bf4168c7ff7ce67a1db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Coronary Disease - immunology</topic><topic>Coronary Disease - mortality</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>end‐stage renal disease</topic><topic>Female</topic><topic>Ferritins - metabolism</topic><topic>haemodialysis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - immunology</topic><topic>Kidney Failure, Chronic - mortality</topic><topic>Leukocyte Count</topic><topic>Linear Models</topic><topic>lymphocytes</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mortality</topic><topic>neutrophils</topic><topic>Neutrophils - metabolism</topic><topic>Renal Dialysis</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reddan, Donal N.</creatorcontrib><creatorcontrib>Klassen, Preston S.</creatorcontrib><creatorcontrib>Szczech, Lynda A.</creatorcontrib><creatorcontrib>Coladonato, Joseph A.</creatorcontrib><creatorcontrib>O'Shea, Susan</creatorcontrib><creatorcontrib>Owen Jr, William F.</creatorcontrib><creatorcontrib>Lowrie, Edmund G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reddan, Donal N.</au><au>Klassen, Preston S.</au><au>Szczech, Lynda A.</au><au>Coladonato, Joseph A.</au><au>O'Shea, Susan</au><au>Owen Jr, William F.</au><au>Lowrie, Edmund G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>White blood cells as a novel mortality predictor in haemodialysis patients</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol. Dial. Transplant</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>18</volume><issue>6</issue><spage>1167</spage><epage>1173</epage><pages>1167-1173</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Many conventional cardiovascular risk factors in the general population are not as predictive in end‐stage renal disease (ESRD). As absolute neutrophil count and total white blood cell (WBC) count are associated with adverse cardiovascular outcomes and all‐cause mortality, this analysis was undertaken to explore the associations of WBC variables with mortality risk in ESRD. Methods. Of a total study population of 44 114 ESRD patients receiving haemodialysis during 1998 at facilities operated by Fresenius Medical Care, North America, 25 661 patients who underwent differential white cell count and had complete follow‐up were included. Information on case mix (age, gender, race), clinical (diabetes, body mass index), and laboratory variables (haematocrit, albumin, creatinine, potassium, calcium, phosphorus, bicarbonate, ferritin, transferrin saturation and differential WBC count) was obtained. Associations between lymphocyte count, neutrophil count and demographic and clinical variables were examined using linear regression. Associations between WBC variables and survival were estimated using Cox proportional hazard regression. Results. A higher lymphocyte count was associated with higher serum albumin and creatinine, lower age and black race. High neutrophil count was associated with lower serum albumin and creatinine, younger age and white race (all Ps <0.0001). Cox proportional hazard regression showed an increased lymphocyte count was associated with reduced mortality risk [HR 0.86 (0.83–0.89) per 500/ml increase in lymphocyte count] and an increased neutrophil count was associated with increased mortality risk [HR 1.08 (1.06–1.09) per 1000/ml increase in neutrophil count]. Conclusions. An increased neutrophil count is strongly associated with, and reduced lymphocyte count associated less strongly with, many surrogates of both malnutrition and inflammation. An increased neutrophil count and reduced lymphocyte count are independent predictors of increased mortality risk in haemodialysis patients.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12748351</pmid><doi>10.1093/ndt/gfg066</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-0509 |
| ispartof | Nephrology, dialysis, transplantation, 2003-06, Vol.18 (6), p.1167-1173 |
| issn | 0931-0509 1460-2385 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73320663 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Coronary Disease - immunology Coronary Disease - mortality Emergency and intensive care: renal failure. Dialysis management end‐stage renal disease Female Ferritins - metabolism haemodialysis Humans Intensive care medicine Kidney Failure, Chronic - immunology Kidney Failure, Chronic - mortality Leukocyte Count Linear Models lymphocytes Lymphocytes - metabolism Male Medical sciences Middle Aged mortality neutrophils Neutrophils - metabolism Renal Dialysis Risk Factors |
| title | White blood cells as a novel mortality predictor in haemodialysis patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T16%3A39%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=White%20blood%20cells%20as%20a%20novel%20mortality%20predictor%20in%20haemodialysis%20patients&rft.jtitle=Nephrology,%20dialysis,%20transplantation&rft.au=Reddan,%20Donal%20N.&rft.date=2003-06-01&rft.volume=18&rft.issue=6&rft.spage=1167&rft.epage=1173&rft.pages=1167-1173&rft.issn=0931-0509&rft.eissn=1460-2385&rft.coden=NDTREA&rft_id=info:doi/10.1093/ndt/gfg066&rft_dat=%3Cproquest_cross%3E73320663%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73320663&rft_id=info:pmid/12748351&rfr_iscdi=true |