Identification of a neuropeptide hormone that regulates sex pheromone production in female moths
A pheromone biosynthesis activating neuropeptide (PBAN) hormone that controls sex pheromone production in female moths was identified from the brain-subesophageal ganglion complexes of the adult corn earworm, Heliothis zea. PBAN has 33 amino acid residues and a molecular weight of 3900. Its amino ac...
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Veröffentlicht in: | Science (American Association for the Advancement of Science) 1989-05, Vol.244 (4906), p.796-798 |
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creator | Raina, A.K. (USDA, ARS, Insect Chemical Ecology Laboratory, Beltsville, MD.) Jaffe, H Kempe, T.G Keim, P Blacher, R.W Fales, H.M Riley, C.T Klun, J.A Ridgway, R.L Hayes, D.K |
description | A pheromone biosynthesis activating neuropeptide (PBAN) hormone that controls sex pheromone production in female moths was identified from the brain-subesophageal ganglion complexes of the adult corn earworm, Heliothis zea. PBAN has 33 amino acid residues and a molecular weight of 3900. Its amino acid sequence has no significant homology with any of the fully characterized peptide hormones. The synthetic peptide, at a dose of between 2 and 4 picomoles, induced production of a normal quantity of sex pheromone in ligated H. zea females. The peptide also induced pheromone production in six other species of moths, thus indicating that this or similar peptides may be responsible for the regulation of pheromone production in moths |
doi_str_mv | 10.1126/science.244.4906.796 |
format | Article |
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(USDA, ARS, Insect Chemical Ecology Laboratory, Beltsville, MD.) ; Jaffe, H ; Kempe, T.G ; Keim, P ; Blacher, R.W ; Fales, H.M ; Riley, C.T ; Klun, J.A ; Ridgway, R.L ; Hayes, D.K</creator><creatorcontrib>Raina, A.K. (USDA, ARS, Insect Chemical Ecology Laboratory, Beltsville, MD.) ; Jaffe, H ; Kempe, T.G ; Keim, P ; Blacher, R.W ; Fales, H.M ; Riley, C.T ; Klun, J.A ; Ridgway, R.L ; Hayes, D.K</creatorcontrib><description>A pheromone biosynthesis activating neuropeptide (PBAN) hormone that controls sex pheromone production in female moths was identified from the brain-subesophageal ganglion complexes of the adult corn earworm, Heliothis zea. PBAN has 33 amino acid residues and a molecular weight of 3900. Its amino acid sequence has no significant homology with any of the fully characterized peptide hormones. The synthetic peptide, at a dose of between 2 and 4 picomoles, induced production of a normal quantity of sex pheromone in ligated H. zea females. The peptide also induced pheromone production in six other species of moths, thus indicating that this or similar peptides may be responsible for the regulation of pheromone production in moths</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.244.4906.796</identifier><identifier>PMID: 17802237</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Amides ; Amino acids ; Aminoacids, peptides. Hormones. Neuropeptides ; Analysis ; Analytical, structural and metabolic biochemistry ; Biochemistry ; Biological and medical sciences ; BIOSINTESIS ; BIOSYNTHESE ; Biosynthesis ; Butterflies & moths ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; Female animals ; FEMELLE ; FEROMONAS ; Fundamental and applied biological sciences. Psychology ; Ganglia ; HELICOVERPA ZEA ; Heliothis zea ; HEMBRA ; HORMONAS ; HORMONAS DE INVERTEBRADOS ; HORMONE ; HORMONE D'INVERTEBRE ; Hormones ; LEPIDOPTERA ; Moths ; Neuropeptides ; Noctuidae ; PEPTIDE ; Peptide hormones ; PEPTIDOS ; PHEROMONE ; Pheromones ; Physiological aspects ; Proteins ; Sex attractants ; SEXE ; SEXO ; SISTEMA NERVIOSO ; Sulfoxides ; SYSTEME NERVEUX</subject><ispartof>Science (American Association for the Advancement of Science), 1989-05, Vol.244 (4906), p.796-798</ispartof><rights>Copyright 1989 The American Association for the Advancement of Science</rights><rights>1991 INIST-CNRS</rights><rights>COPYRIGHT 1989 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1989 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science May 19, 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c761t-f3cf3e58bb3fe263ddbd16f9d84cbdff39fbe5634109320763df71e7c1684f2c3</citedby><cites>FETCH-LOGICAL-c761t-f3cf3e58bb3fe263ddbd16f9d84cbdff39fbe5634109320763df71e7c1684f2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1703518$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1703518$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19409071$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17802237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raina, A.K. (USDA, ARS, Insect Chemical Ecology Laboratory, Beltsville, MD.)</creatorcontrib><creatorcontrib>Jaffe, H</creatorcontrib><creatorcontrib>Kempe, T.G</creatorcontrib><creatorcontrib>Keim, P</creatorcontrib><creatorcontrib>Blacher, R.W</creatorcontrib><creatorcontrib>Fales, H.M</creatorcontrib><creatorcontrib>Riley, C.T</creatorcontrib><creatorcontrib>Klun, J.A</creatorcontrib><creatorcontrib>Ridgway, R.L</creatorcontrib><creatorcontrib>Hayes, D.K</creatorcontrib><title>Identification of a neuropeptide hormone that regulates sex pheromone production in female moths</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>A pheromone biosynthesis activating neuropeptide (PBAN) hormone that controls sex pheromone production in female moths was identified from the brain-subesophageal ganglion complexes of the adult corn earworm, Heliothis zea. PBAN has 33 amino acid residues and a molecular weight of 3900. Its amino acid sequence has no significant homology with any of the fully characterized peptide hormones. The synthetic peptide, at a dose of between 2 and 4 picomoles, induced production of a normal quantity of sex pheromone in ligated H. zea females. The peptide also induced pheromone production in six other species of moths, thus indicating that this or similar peptides may be responsible for the regulation of pheromone production in moths</description><subject>Amides</subject><subject>Amino acids</subject><subject>Aminoacids, peptides. Hormones. Neuropeptides</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>BIOSINTESIS</subject><subject>BIOSYNTHESE</subject><subject>Biosynthesis</subject><subject>Butterflies & moths</subject><subject>COMPOSICION QUIMICA</subject><subject>COMPOSITION CHIMIQUE</subject><subject>Female animals</subject><subject>FEMELLE</subject><subject>FEROMONAS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia</subject><subject>HELICOVERPA ZEA</subject><subject>Heliothis zea</subject><subject>HEMBRA</subject><subject>HORMONAS</subject><subject>HORMONAS DE INVERTEBRADOS</subject><subject>HORMONE</subject><subject>HORMONE D'INVERTEBRE</subject><subject>Hormones</subject><subject>LEPIDOPTERA</subject><subject>Moths</subject><subject>Neuropeptides</subject><subject>Noctuidae</subject><subject>PEPTIDE</subject><subject>Peptide hormones</subject><subject>PEPTIDOS</subject><subject>PHEROMONE</subject><subject>Pheromones</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Sex attractants</subject><subject>SEXE</subject><subject>SEXO</subject><subject>SISTEMA NERVIOSO</subject><subject>Sulfoxides</subject><subject>SYSTEME NERVEUX</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN01Fv0zAQAOAIgVgZ_AE0oQgJ9jBa7DhxksdRQalU0YcxXo3jnFNXSVxsRxr_nutaaQVVrMpDpNzn0-V8F0UXlEwoTfhHrwz0CiZJmk7SkvBJXvIn0YiSMhuXCWFPoxEhjI8Lkmdn0Qvv14RgrGTPozOaFyRJWD6Kfs5r6IPRRslgbB9bHcu4h8HZDWyCqSFeWdfZHuKwkiF20AytDOBjD3fxZgXO3gc3ztaDus9g-lhDJ1uIOxtW_mX0TMvWw6v9-zy6_fL5-_TreLGczafXi7HKOQ1jzZRmkBVVxTQknNV1VVOuy7pIVVVrzUpdQcZZiv_HEpKj0DmFXFFepDpR7Dy63OXFUn4N4IPojFfQtrIHO3iRMzyW8SJB-f6_kmWUcZ7SR2FCKUtTTh6FNEtYiikRvv0Hru3geuwLJmMZK8tsW9_VDjXYRGF6bYOTqoEenGyx2drg5-ucIyUM9YcjGp8aOqOO8Mu_OIoAd6GRg_difvPtVLn8car8NDtRFrPFobw6JpVtW2hA4OhMl4c63WnlrPcOtNg400n3W1Aittsi9tsicFvEdlsEbgsee7O_jqHqoH44tF8PBO_2QHolW-1kr4x_cGVKSpJvJ-Vi59Y-WHeQh-AwFRh-vQtraYVsHKa4vSnxujMs_w_k0izD</recordid><startdate>19890519</startdate><enddate>19890519</enddate><creator>Raina, A.K. 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(USDA, ARS, Insect Chemical Ecology Laboratory, Beltsville, MD.) ; Jaffe, H ; Kempe, T.G ; Keim, P ; Blacher, R.W ; Fales, H.M ; Riley, C.T ; Klun, J.A ; Ridgway, R.L ; Hayes, D.K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c761t-f3cf3e58bb3fe263ddbd16f9d84cbdff39fbe5634109320763df71e7c1684f2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Amides</topic><topic>Amino acids</topic><topic>Aminoacids, peptides. Hormones. Neuropeptides</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>BIOSINTESIS</topic><topic>BIOSYNTHESE</topic><topic>Biosynthesis</topic><topic>Butterflies & moths</topic><topic>COMPOSICION QUIMICA</topic><topic>COMPOSITION CHIMIQUE</topic><topic>Female animals</topic><topic>FEMELLE</topic><topic>FEROMONAS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia</topic><topic>HELICOVERPA ZEA</topic><topic>Heliothis zea</topic><topic>HEMBRA</topic><topic>HORMONAS</topic><topic>HORMONAS DE INVERTEBRADOS</topic><topic>HORMONE</topic><topic>HORMONE D'INVERTEBRE</topic><topic>Hormones</topic><topic>LEPIDOPTERA</topic><topic>Moths</topic><topic>Neuropeptides</topic><topic>Noctuidae</topic><topic>PEPTIDE</topic><topic>Peptide hormones</topic><topic>PEPTIDOS</topic><topic>PHEROMONE</topic><topic>Pheromones</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Sex attractants</topic><topic>SEXE</topic><topic>SEXO</topic><topic>SISTEMA NERVIOSO</topic><topic>Sulfoxides</topic><topic>SYSTEME NERVEUX</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raina, A.K. 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Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raina, A.K. (USDA, ARS, Insect Chemical Ecology Laboratory, Beltsville, MD.)</au><au>Jaffe, H</au><au>Kempe, T.G</au><au>Keim, P</au><au>Blacher, R.W</au><au>Fales, H.M</au><au>Riley, C.T</au><au>Klun, J.A</au><au>Ridgway, R.L</au><au>Hayes, D.K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a neuropeptide hormone that regulates sex pheromone production in female moths</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1989-05-19</date><risdate>1989</risdate><volume>244</volume><issue>4906</issue><spage>796</spage><epage>798</epage><pages>796-798</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>A pheromone biosynthesis activating neuropeptide (PBAN) hormone that controls sex pheromone production in female moths was identified from the brain-subesophageal ganglion complexes of the adult corn earworm, Heliothis zea. PBAN has 33 amino acid residues and a molecular weight of 3900. Its amino acid sequence has no significant homology with any of the fully characterized peptide hormones. The synthetic peptide, at a dose of between 2 and 4 picomoles, induced production of a normal quantity of sex pheromone in ligated H. zea females. The peptide also induced pheromone production in six other species of moths, thus indicating that this or similar peptides may be responsible for the regulation of pheromone production in moths</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>17802237</pmid><doi>10.1126/science.244.4906.796</doi><tpages>3</tpages></addata></record> |
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ispartof | Science (American Association for the Advancement of Science), 1989-05, Vol.244 (4906), p.796-798 |
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source | American Association for the Advancement of Science; Jstor Complete Legacy |
subjects | Amides Amino acids Aminoacids, peptides. Hormones. Neuropeptides Analysis Analytical, structural and metabolic biochemistry Biochemistry Biological and medical sciences BIOSINTESIS BIOSYNTHESE Biosynthesis Butterflies & moths COMPOSICION QUIMICA COMPOSITION CHIMIQUE Female animals FEMELLE FEROMONAS Fundamental and applied biological sciences. Psychology Ganglia HELICOVERPA ZEA Heliothis zea HEMBRA HORMONAS HORMONAS DE INVERTEBRADOS HORMONE HORMONE D'INVERTEBRE Hormones LEPIDOPTERA Moths Neuropeptides Noctuidae PEPTIDE Peptide hormones PEPTIDOS PHEROMONE Pheromones Physiological aspects Proteins Sex attractants SEXE SEXO SISTEMA NERVIOSO Sulfoxides SYSTEME NERVEUX |
title | Identification of a neuropeptide hormone that regulates sex pheromone production in female moths |
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