Human Immunodeficiency Virus-1 RNA Levels in Cerebrospinal Fluid Exhibit a Set Point in Clinically Stable Patients Not Receiving Antiretroviral Therapy
To characterize, over time, cerebrospinal fluid (CSF) virus-load change in clinically stable patients, human immunodeficiency virus (HIV)-1 RNA levels were measured in serial CSF samples and in plasma samples obtained, during periods of 20 days–6 years, from 17 HIV-infected individuals not receiving...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 2003-06, Vol.187 (11), p.1818-1821 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1821 |
|---|---|
| container_issue | 11 |
| container_start_page | 1818 |
| container_title | The Journal of infectious diseases |
| container_volume | 187 |
| creator | Ellis, Ronald J. Childers, Meredith E. Zimmerman, Joshua D. Frost, Simon D. W. Deutsch, Reena McCutchan, J. Allen |
| description | To characterize, over time, cerebrospinal fluid (CSF) virus-load change in clinically stable patients, human immunodeficiency virus (HIV)-1 RNA levels were measured in serial CSF samples and in plasma samples obtained, during periods of 20 days–6 years, from 17 HIV-infected individuals not receiving antiretroviral treatment. Longitudinal trends were analyzed by linear regression and restricted maximum-likelihood techniques. CSF HIV-1 RNA levels varied within a restricted range (±0.5 log10 copies/mL) around each subject-specific mean. Although 16 of the 17 subjects had CSF slopes not significantly different from zero, slopes that were more positive were associated with lower CD4 counts. In an individual patient, a CSF virus-load change >0.5 log10 copies/mL may be clinically significant. Furthermore, our data suggest that, if the CSF virus load reflects the size of the reservoir of infected cells in the central nervous system, this reservoir may increase in those individuals with advanced immunosuppression but is stable, over several years, in patients without AIDS |
| doi_str_mv | 10.1086/375152 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_73320443</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30085672</jstor_id><oup_id>10.1086/375152</oup_id><sourcerecordid>30085672</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-7ac6df60aa69438ba31416edcf9def1d8b8267667209453c7b5578c5b35cb92d3</originalsourceid><addsrcrecordid>eNqF0d1u0zAUB_AIgVgZ8AYgDwnuAv6IP3JZqm2dVI1pHRPixnIch7kkTrCdan0SXhdDqlVCQlz54vz8PzrnZNlLBN8jKNgHwimi-FE2Q5TwnDFEHmczCDHOkSjLo-xZCBsIYUEYf5odIZw4LNAs-7kcO-XARdeNrq9NY7U1Tu_ArfVjyBG4vpyDldmaNgDrwMJ4U_k-DNapFpy1o63B6f2drWwECqxNBFe9dfEPba2zWrXtDqyjqloDrlRM2TGAyz6Ca6ON3Vr3DcxdtN5E32-tT6E3d8arYfc8e9KoNpgX-_c4-3x2erNY5qtP5xeL-SrXhUAx50qzumFQKVYWRFSKoAIxU-umTMOgWlQCM84Yx7AsKNG8opQLTStCdVXimhxn76bcwfc_RhOi7GzQpm2VM_0YJCcEw6Ig_4VIiNSFswTf_AU3_ejTvoLEmJSooCU-pOm0zeBNIwdvO-V3EkH5-6ByOmiCr_dpY9WZ-sD2F0zg7R6okNbdeOW0DQdXCMoJhMmdTK4fh383ezWZTYi9f1Dpu6BpuFTPp7oN0dw_1JX_LhlPGXL55assP96uV-eQSEJ-AWsyygQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223914592</pqid></control><display><type>article</type><title>Human Immunodeficiency Virus-1 RNA Levels in Cerebrospinal Fluid Exhibit a Set Point in Clinically Stable Patients Not Receiving Antiretroviral Therapy</title><source>Jstor Complete Legacy</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Ellis, Ronald J. ; Childers, Meredith E. ; Zimmerman, Joshua D. ; Frost, Simon D. W. ; Deutsch, Reena ; McCutchan, J. Allen</creator><creatorcontrib>Ellis, Ronald J. ; Childers, Meredith E. ; Zimmerman, Joshua D. ; Frost, Simon D. W. ; Deutsch, Reena ; McCutchan, J. Allen ; HIV Neurobehavioral Research Center Group ; HIV Neurobehavioral Research Center Group ; the HIV Neurobehavioral Research Center Group</creatorcontrib><description>To characterize, over time, cerebrospinal fluid (CSF) virus-load change in clinically stable patients, human immunodeficiency virus (HIV)-1 RNA levels were measured in serial CSF samples and in plasma samples obtained, during periods of 20 days–6 years, from 17 HIV-infected individuals not receiving antiretroviral treatment. Longitudinal trends were analyzed by linear regression and restricted maximum-likelihood techniques. CSF HIV-1 RNA levels varied within a restricted range (±0.5 log10 copies/mL) around each subject-specific mean. Although 16 of the 17 subjects had CSF slopes not significantly different from zero, slopes that were more positive were associated with lower CD4 counts. In an individual patient, a CSF virus-load change >0.5 log10 copies/mL may be clinically significant. Furthermore, our data suggest that, if the CSF virus load reflects the size of the reservoir of infected cells in the central nervous system, this reservoir may increase in those individuals with advanced immunosuppression but is stable, over several years, in patients without AIDS</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/375152</identifier><identifier>PMID: 12751041</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; AIDS ; Anti-HIV Agents - therapeutic use ; antiretroviral therapy ; Antiretrovirals ; Biological and medical sciences ; Blood plasma ; CD4 antigen ; CD4 Lymphocyte Count ; Cerebrospinal fluid ; Disease reservoirs ; Female ; HIV ; HIV 1 ; HIV Infections - cerebrospinal fluid ; HIV Infections - drug therapy ; HIV Infections - virology ; HIV-1 - genetics ; HIV-1 - isolation & purification ; HIV/AIDS ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Likelihood Functions ; Linear Models ; Male ; Medical sciences ; Middle Aged ; Research facilities ; RNA ; RNA, Viral - cerebrospinal fluid ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Viruses</subject><ispartof>The Journal of infectious diseases, 2003-06, Vol.187 (11), p.1818-1821</ispartof><rights>Copyright 2003 Infectious Diseases Society of America</rights><rights>2003 by the Infectious Diseases Society of America 2003</rights><rights>2003 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jun 1 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-7ac6df60aa69438ba31416edcf9def1d8b8267667209453c7b5578c5b35cb92d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30085672$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30085672$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14857300$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12751041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellis, Ronald J.</creatorcontrib><creatorcontrib>Childers, Meredith E.</creatorcontrib><creatorcontrib>Zimmerman, Joshua D.</creatorcontrib><creatorcontrib>Frost, Simon D. W.</creatorcontrib><creatorcontrib>Deutsch, Reena</creatorcontrib><creatorcontrib>McCutchan, J. Allen</creatorcontrib><creatorcontrib>HIV Neurobehavioral Research Center Group</creatorcontrib><creatorcontrib>HIV Neurobehavioral Research Center Group</creatorcontrib><creatorcontrib>the HIV Neurobehavioral Research Center Group</creatorcontrib><title>Human Immunodeficiency Virus-1 RNA Levels in Cerebrospinal Fluid Exhibit a Set Point in Clinically Stable Patients Not Receiving Antiretroviral Therapy</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>To characterize, over time, cerebrospinal fluid (CSF) virus-load change in clinically stable patients, human immunodeficiency virus (HIV)-1 RNA levels were measured in serial CSF samples and in plasma samples obtained, during periods of 20 days–6 years, from 17 HIV-infected individuals not receiving antiretroviral treatment. Longitudinal trends were analyzed by linear regression and restricted maximum-likelihood techniques. CSF HIV-1 RNA levels varied within a restricted range (±0.5 log10 copies/mL) around each subject-specific mean. Although 16 of the 17 subjects had CSF slopes not significantly different from zero, slopes that were more positive were associated with lower CD4 counts. In an individual patient, a CSF virus-load change >0.5 log10 copies/mL may be clinically significant. Furthermore, our data suggest that, if the CSF virus load reflects the size of the reservoir of infected cells in the central nervous system, this reservoir may increase in those individuals with advanced immunosuppression but is stable, over several years, in patients without AIDS</description><subject>Adult</subject><subject>AIDS</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>antiretroviral therapy</subject><subject>Antiretrovirals</subject><subject>Biological and medical sciences</subject><subject>Blood plasma</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>Cerebrospinal fluid</subject><subject>Disease reservoirs</subject><subject>Female</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Infections - cerebrospinal fluid</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - isolation & purification</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Likelihood Functions</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Research facilities</subject><subject>RNA</subject><subject>RNA, Viral - cerebrospinal fluid</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0d1u0zAUB_AIgVgZ8AYgDwnuAv6IP3JZqm2dVI1pHRPixnIch7kkTrCdan0SXhdDqlVCQlz54vz8PzrnZNlLBN8jKNgHwimi-FE2Q5TwnDFEHmczCDHOkSjLo-xZCBsIYUEYf5odIZw4LNAs-7kcO-XARdeNrq9NY7U1Tu_ArfVjyBG4vpyDldmaNgDrwMJ4U_k-DNapFpy1o63B6f2drWwECqxNBFe9dfEPba2zWrXtDqyjqloDrlRM2TGAyz6Ca6ON3Vr3DcxdtN5E32-tT6E3d8arYfc8e9KoNpgX-_c4-3x2erNY5qtP5xeL-SrXhUAx50qzumFQKVYWRFSKoAIxU-umTMOgWlQCM84Yx7AsKNG8opQLTStCdVXimhxn76bcwfc_RhOi7GzQpm2VM_0YJCcEw6Ig_4VIiNSFswTf_AU3_ejTvoLEmJSooCU-pOm0zeBNIwdvO-V3EkH5-6ByOmiCr_dpY9WZ-sD2F0zg7R6okNbdeOW0DQdXCMoJhMmdTK4fh383ezWZTYi9f1Dpu6BpuFTPp7oN0dw_1JX_LhlPGXL55assP96uV-eQSEJ-AWsyygQ</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Ellis, Ronald J.</creator><creator>Childers, Meredith E.</creator><creator>Zimmerman, Joshua D.</creator><creator>Frost, Simon D. W.</creator><creator>Deutsch, Reena</creator><creator>McCutchan, J. Allen</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Human Immunodeficiency Virus-1 RNA Levels in Cerebrospinal Fluid Exhibit a Set Point in Clinically Stable Patients Not Receiving Antiretroviral Therapy</title><author>Ellis, Ronald J. ; Childers, Meredith E. ; Zimmerman, Joshua D. ; Frost, Simon D. W. ; Deutsch, Reena ; McCutchan, J. Allen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-7ac6df60aa69438ba31416edcf9def1d8b8267667209453c7b5578c5b35cb92d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>AIDS</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>antiretroviral therapy</topic><topic>Antiretrovirals</topic><topic>Biological and medical sciences</topic><topic>Blood plasma</topic><topic>CD4 antigen</topic><topic>CD4 Lymphocyte Count</topic><topic>Cerebrospinal fluid</topic><topic>Disease reservoirs</topic><topic>Female</topic><topic>HIV</topic><topic>HIV 1</topic><topic>HIV Infections - cerebrospinal fluid</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - isolation & purification</topic><topic>HIV/AIDS</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Likelihood Functions</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Research facilities</topic><topic>RNA</topic><topic>RNA, Viral - cerebrospinal fluid</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ellis, Ronald J.</creatorcontrib><creatorcontrib>Childers, Meredith E.</creatorcontrib><creatorcontrib>Zimmerman, Joshua D.</creatorcontrib><creatorcontrib>Frost, Simon D. W.</creatorcontrib><creatorcontrib>Deutsch, Reena</creatorcontrib><creatorcontrib>McCutchan, J. Allen</creatorcontrib><creatorcontrib>HIV Neurobehavioral Research Center Group</creatorcontrib><creatorcontrib>HIV Neurobehavioral Research Center Group</creatorcontrib><creatorcontrib>the HIV Neurobehavioral Research Center Group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellis, Ronald J.</au><au>Childers, Meredith E.</au><au>Zimmerman, Joshua D.</au><au>Frost, Simon D. W.</au><au>Deutsch, Reena</au><au>McCutchan, J. Allen</au><aucorp>HIV Neurobehavioral Research Center Group</aucorp><aucorp>HIV Neurobehavioral Research Center Group</aucorp><aucorp>the HIV Neurobehavioral Research Center Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Immunodeficiency Virus-1 RNA Levels in Cerebrospinal Fluid Exhibit a Set Point in Clinically Stable Patients Not Receiving Antiretroviral Therapy</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>187</volume><issue>11</issue><spage>1818</spage><epage>1821</epage><pages>1818-1821</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To characterize, over time, cerebrospinal fluid (CSF) virus-load change in clinically stable patients, human immunodeficiency virus (HIV)-1 RNA levels were measured in serial CSF samples and in plasma samples obtained, during periods of 20 days–6 years, from 17 HIV-infected individuals not receiving antiretroviral treatment. Longitudinal trends were analyzed by linear regression and restricted maximum-likelihood techniques. CSF HIV-1 RNA levels varied within a restricted range (±0.5 log10 copies/mL) around each subject-specific mean. Although 16 of the 17 subjects had CSF slopes not significantly different from zero, slopes that were more positive were associated with lower CD4 counts. In an individual patient, a CSF virus-load change >0.5 log10 copies/mL may be clinically significant. Furthermore, our data suggest that, if the CSF virus load reflects the size of the reservoir of infected cells in the central nervous system, this reservoir may increase in those individuals with advanced immunosuppression but is stable, over several years, in patients without AIDS</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12751041</pmid><doi>10.1086/375152</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2003-06, Vol.187 (11), p.1818-1821 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73320443 |
| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult AIDS Anti-HIV Agents - therapeutic use antiretroviral therapy Antiretrovirals Biological and medical sciences Blood plasma CD4 antigen CD4 Lymphocyte Count Cerebrospinal fluid Disease reservoirs Female HIV HIV 1 HIV Infections - cerebrospinal fluid HIV Infections - drug therapy HIV Infections - virology HIV-1 - genetics HIV-1 - isolation & purification HIV/AIDS Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Likelihood Functions Linear Models Male Medical sciences Middle Aged Research facilities RNA RNA, Viral - cerebrospinal fluid Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Viruses |
| title | Human Immunodeficiency Virus-1 RNA Levels in Cerebrospinal Fluid Exhibit a Set Point in Clinically Stable Patients Not Receiving Antiretroviral Therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T00%3A51%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20Immunodeficiency%20Virus-1%20RNA%20Levels%20in%20Cerebrospinal%20Fluid%20Exhibit%20a%20Set%20Point%20in%20Clinically%20Stable%20Patients%20Not%20Receiving%20Antiretroviral%20Therapy&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Ellis,%20Ronald%20J.&rft.aucorp=HIV%20Neurobehavioral%20Research%20Center%20Group&rft.date=2003-06-01&rft.volume=187&rft.issue=11&rft.spage=1818&rft.epage=1821&rft.pages=1818-1821&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1086/375152&rft_dat=%3Cjstor_proqu%3E30085672%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223914592&rft_id=info:pmid/12751041&rft_jstor_id=30085672&rft_oup_id=10.1086/375152&rfr_iscdi=true |