Theophylline Attenuates the Adhesion of Eosinophils to Endothelial Cells

Background: Bronchial asthma is characterized by infiltration of eosinophils and other inflammatory cells into the airways. Binding to adhesion molecules expressed on endothelial cells is an initial step of eosinophil accumulation in the airways of asthmatic patients. Theophylline has been widely us...

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Veröffentlicht in:	International archives of allergy and immunology 2003-01, Vol.131 (Suppl 1), p.40-45
Hauptverfasser:	Choo, Jae Hong, Nagata, Makoto, Sutani, Akihisa, Kikuchi, Izumi, Sakamoto, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergic diseases Asthma - blood Asthma - drug therapy Biological and medical sciences Bronchodilator Agents - therapeutic use Cell Adhesion - drug effects Cyclic AMP - metabolism Cyclic AMP - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Eosinophils - cytology Eosinophils - drug effects Female Humans Immunopathology Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - drug effects Interleukin-4 - pharmacology Interleukin-5 - pharmacology Male Medical sciences N-Formylmethionine Leucyl-Phenylalanine - pharmacology Original Paper Phosphodiesterase Inhibitors - pharmacology Phosphoric Diester Hydrolases - drug effects Respiratory and ent allergic diseases Rolipram - pharmacology Theophylline - therapeutic use Tumor Necrosis Factor-alpha - pharmacology Umbilical Veins - cytology Umbilical Veins - metabolism Vascular Cell Adhesion Molecule-1 - biosynthesis Vascular Cell Adhesion Molecule-1 - drug effects
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