5-Arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists

The structure–activity relationships of a series of 5-arylamino-1,2,4-triazin-6(1H)-ones as corticotropin releasing factor-1 receptor antagonists was investigated. A series of 5-arylamino-1,2,4-triazin-6(1H)-ones was synthesized and evaluated as antagonists at the corticotropin releasing factor rece...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-06, Vol.20 (12), p.3579-3583
Hauptverfasser:	Schmitz, William D., Brenner, Allison B., Bronson, Joanne J., Ditta, Jonathan L., Griffin, Corrine R., Li, Yu-Wen, Lodge, Nicholas J., Molski, Thaddeus F., Olson, Richard E., Zhuo, Xiaoliang, Macor, John E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Corticotropin releasing factor Depression Humans Inhibitory Concentration 50 Medical sciences Neuropharmacology Oxidation-Reduction Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyrazines Rats Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Structure-Activity Relationship Triazines - chemical synthesis Triazines - pharmacology Triazinone
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