New Therapies Targeting the Genetic Mutations Responsible for Different Types of Melanoma

A number of molecular alterations have been described for melanoma. Melanomas with BRAF mutations tend to be located in areas of intermittent sun exposure, whereas melanomas with KIT mutations mostly appear in acral areas, the mucosa, and areas of chronic sun exposure. Sorafenib, a BRAF inhibitor, h...

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Veröffentlicht in:	Actas dermo-sifiliográficas (English ed.) 2010-06, Vol.101 (5), p.394-400
Hauptverfasser:	Botella-Estrada, R., Sanmartín Jiménez, O.
Format:	Artikel
Sprache:	eng ; spa
Schlagworte:	BRAF Humans Imatinib MAPK Melanoma Melanoma - drug therapy Melanoma - genetics Mitogen-Activated Protein Kinases - genetics Mutation Proto-Oncogene Proteins c-kit - genetics Skin Neoplasms - drug therapy Skin Neoplasms - genetics Sorafenib
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