Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging
It has been suggested that the pathophysiology of panic disorder (PD) may involve abnormalities in several brain structures, including the amygdala. To date, however, no study has used quantitative structural neuroimaging techniques to examine amygdalar anatomy in this disorder. Volumetric magnetic...
Gespeichert in:
| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2003-05, Vol.19 (1), p.80-90 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 90 |
|---|---|
| container_issue | 1 |
| container_start_page | 80 |
| container_title | NeuroImage (Orlando, Fla.) |
| container_volume | 19 |
| creator | Massana, Guillem Serra-Grabulosa, Josep Maria Salgado-Pineda, Pilar Gastó, Cristòbal Junqué, Carme Massana, Joan Mercader, José Maria Gómez, Beatriz Tobeña, Adolf Salamero, Manel |
| description | It has been suggested that the pathophysiology of panic disorder (PD) may involve abnormalities in several brain structures, including the amygdala. To date, however, no study has used quantitative structural neuroimaging techniques to examine amygdalar anatomy in this disorder. Volumetric magnetic resonance imaging (MRI) studies of the amygdalas, hippocampi, and temporal lobes were conducted in 12 drug-free, symptomatic PD patients (six females and six males), and 12 case-matched healthy comparison subjects. Volumetric MRI data were normalized for brain size. PD patients were found to have smaller left-sided and right-sided amygdalar volumes than controls. No differences were found in either hippocampi or temporal lobes. These findings provide new evidence of changes in amygdalar structure in PD and warrant further anatomical and MRI brain studies of patients with this disorder. |
| doi_str_mv | 10.1016/S1053-8119(03)00036-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73318402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1053811903000363</els_id><sourcerecordid>3244193911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-51edcfbc61e19114eac86f187214ce28ffc5b3336f614c9b0ee7c1e2392ba833</originalsourceid><addsrcrecordid>eNqFkE1r3DAQQEVJ6W42_QkphkBID040lmXLpxBC-gGBHpJzhSyNN1psaSvJgf330WYXCr0UHWY0PI1mHiHnQK-BQnPzBJSzUgB0V5R9pZSypmQfyBJox8uOt9XJPj8iC3Ia4yZDHdTiE1lA1QpoK7Ekv--m3dqoUYVCpeC3L7vCumKrnNWFsdEHgyFfk0WXYmEwoU5oin5XvPpxnjCFDE5q7TDlJGD0TjmNhc0169Zn5OOgxoifj3FFnr89PN__KB9_ff95f_dY6przVHJAo4deN4DQAdSotGgGEG0FtcZKDIPmPWOsGZpc6HqK2GrAinVVrwRjK3J5aLsN_s-MMcnJRo3jqBz6OcqWMRA1rTJ48Q-48XNweTQJnDa8E_lkih8oHXyMAQe5DXmhsJNA5d6-fLcv92olZfLdvtyP8eXYfe4nNH9fHXVn4PYAYHbxajHIqLNZjcaGLFYab__zxRuwp5Ud</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506598989</pqid></control><display><type>article</type><title>Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Massana, Guillem ; Serra-Grabulosa, Josep Maria ; Salgado-Pineda, Pilar ; Gastó, Cristòbal ; Junqué, Carme ; Massana, Joan ; Mercader, José Maria ; Gómez, Beatriz ; Tobeña, Adolf ; Salamero, Manel</creator><creatorcontrib>Massana, Guillem ; Serra-Grabulosa, Josep Maria ; Salgado-Pineda, Pilar ; Gastó, Cristòbal ; Junqué, Carme ; Massana, Joan ; Mercader, José Maria ; Gómez, Beatriz ; Tobeña, Adolf ; Salamero, Manel</creatorcontrib><description>It has been suggested that the pathophysiology of panic disorder (PD) may involve abnormalities in several brain structures, including the amygdala. To date, however, no study has used quantitative structural neuroimaging techniques to examine amygdalar anatomy in this disorder. Volumetric magnetic resonance imaging (MRI) studies of the amygdalas, hippocampi, and temporal lobes were conducted in 12 drug-free, symptomatic PD patients (six females and six males), and 12 case-matched healthy comparison subjects. Volumetric MRI data were normalized for brain size. PD patients were found to have smaller left-sided and right-sided amygdalar volumes than controls. No differences were found in either hippocampi or temporal lobes. These findings provide new evidence of changes in amygdalar structure in PD and warrant further anatomical and MRI brain studies of patients with this disorder.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/S1053-8119(03)00036-3</identifier><identifier>PMID: 12781728</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Amygdala - pathology ; Anxiety ; Atrophy ; Female ; Hippocampus - pathology ; Humans ; Magnetic Resonance Imaging ; Male ; NMR ; Nuclear magnetic resonance ; Panic attacks ; Panic Disorder - diagnosis ; Schizophrenia ; Temporal Lobe - pathology</subject><ispartof>NeuroImage (Orlando, Fla.), 2003-05, Vol.19 (1), p.80-90</ispartof><rights>2003 Elsevier Science (USA)</rights><rights>Copyright Elsevier Limited May 1, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-51edcfbc61e19114eac86f187214ce28ffc5b3336f614c9b0ee7c1e2392ba833</citedby><cites>FETCH-LOGICAL-c455t-51edcfbc61e19114eac86f187214ce28ffc5b3336f614c9b0ee7c1e2392ba833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1506598989?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12781728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Massana, Guillem</creatorcontrib><creatorcontrib>Serra-Grabulosa, Josep Maria</creatorcontrib><creatorcontrib>Salgado-Pineda, Pilar</creatorcontrib><creatorcontrib>Gastó, Cristòbal</creatorcontrib><creatorcontrib>Junqué, Carme</creatorcontrib><creatorcontrib>Massana, Joan</creatorcontrib><creatorcontrib>Mercader, José Maria</creatorcontrib><creatorcontrib>Gómez, Beatriz</creatorcontrib><creatorcontrib>Tobeña, Adolf</creatorcontrib><creatorcontrib>Salamero, Manel</creatorcontrib><title>Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>It has been suggested that the pathophysiology of panic disorder (PD) may involve abnormalities in several brain structures, including the amygdala. To date, however, no study has used quantitative structural neuroimaging techniques to examine amygdalar anatomy in this disorder. Volumetric magnetic resonance imaging (MRI) studies of the amygdalas, hippocampi, and temporal lobes were conducted in 12 drug-free, symptomatic PD patients (six females and six males), and 12 case-matched healthy comparison subjects. Volumetric MRI data were normalized for brain size. PD patients were found to have smaller left-sided and right-sided amygdalar volumes than controls. No differences were found in either hippocampi or temporal lobes. These findings provide new evidence of changes in amygdalar structure in PD and warrant further anatomical and MRI brain studies of patients with this disorder.</description><subject>Adult</subject><subject>Amygdala - pathology</subject><subject>Anxiety</subject><subject>Atrophy</subject><subject>Female</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Panic attacks</subject><subject>Panic Disorder - diagnosis</subject><subject>Schizophrenia</subject><subject>Temporal Lobe - pathology</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkE1r3DAQQEVJ6W42_QkphkBID040lmXLpxBC-gGBHpJzhSyNN1psaSvJgf330WYXCr0UHWY0PI1mHiHnQK-BQnPzBJSzUgB0V5R9pZSypmQfyBJox8uOt9XJPj8iC3Ia4yZDHdTiE1lA1QpoK7Ekv--m3dqoUYVCpeC3L7vCumKrnNWFsdEHgyFfk0WXYmEwoU5oin5XvPpxnjCFDE5q7TDlJGD0TjmNhc0169Zn5OOgxoifj3FFnr89PN__KB9_ff95f_dY6przVHJAo4deN4DQAdSotGgGEG0FtcZKDIPmPWOsGZpc6HqK2GrAinVVrwRjK3J5aLsN_s-MMcnJRo3jqBz6OcqWMRA1rTJ48Q-48XNweTQJnDa8E_lkih8oHXyMAQe5DXmhsJNA5d6-fLcv92olZfLdvtyP8eXYfe4nNH9fHXVn4PYAYHbxajHIqLNZjcaGLFYab__zxRuwp5Ud</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Massana, Guillem</creator><creator>Serra-Grabulosa, Josep Maria</creator><creator>Salgado-Pineda, Pilar</creator><creator>Gastó, Cristòbal</creator><creator>Junqué, Carme</creator><creator>Massana, Joan</creator><creator>Mercader, José Maria</creator><creator>Gómez, Beatriz</creator><creator>Tobeña, Adolf</creator><creator>Salamero, Manel</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging</title><author>Massana, Guillem ; Serra-Grabulosa, Josep Maria ; Salgado-Pineda, Pilar ; Gastó, Cristòbal ; Junqué, Carme ; Massana, Joan ; Mercader, José Maria ; Gómez, Beatriz ; Tobeña, Adolf ; Salamero, Manel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-51edcfbc61e19114eac86f187214ce28ffc5b3336f614c9b0ee7c1e2392ba833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Amygdala - pathology</topic><topic>Anxiety</topic><topic>Atrophy</topic><topic>Female</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Panic attacks</topic><topic>Panic Disorder - diagnosis</topic><topic>Schizophrenia</topic><topic>Temporal Lobe - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Massana, Guillem</creatorcontrib><creatorcontrib>Serra-Grabulosa, Josep Maria</creatorcontrib><creatorcontrib>Salgado-Pineda, Pilar</creatorcontrib><creatorcontrib>Gastó, Cristòbal</creatorcontrib><creatorcontrib>Junqué, Carme</creatorcontrib><creatorcontrib>Massana, Joan</creatorcontrib><creatorcontrib>Mercader, José Maria</creatorcontrib><creatorcontrib>Gómez, Beatriz</creatorcontrib><creatorcontrib>Tobeña, Adolf</creatorcontrib><creatorcontrib>Salamero, Manel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Massana, Guillem</au><au>Serra-Grabulosa, Josep Maria</au><au>Salgado-Pineda, Pilar</au><au>Gastó, Cristòbal</au><au>Junqué, Carme</au><au>Massana, Joan</au><au>Mercader, José Maria</au><au>Gómez, Beatriz</au><au>Tobeña, Adolf</au><au>Salamero, Manel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>19</volume><issue>1</issue><spage>80</spage><epage>90</epage><pages>80-90</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>It has been suggested that the pathophysiology of panic disorder (PD) may involve abnormalities in several brain structures, including the amygdala. To date, however, no study has used quantitative structural neuroimaging techniques to examine amygdalar anatomy in this disorder. Volumetric magnetic resonance imaging (MRI) studies of the amygdalas, hippocampi, and temporal lobes were conducted in 12 drug-free, symptomatic PD patients (six females and six males), and 12 case-matched healthy comparison subjects. Volumetric MRI data were normalized for brain size. PD patients were found to have smaller left-sided and right-sided amygdalar volumes than controls. No differences were found in either hippocampi or temporal lobes. These findings provide new evidence of changes in amygdalar structure in PD and warrant further anatomical and MRI brain studies of patients with this disorder.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12781728</pmid><doi>10.1016/S1053-8119(03)00036-3</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-8119 |
| ispartof | NeuroImage (Orlando, Fla.), 2003-05, Vol.19 (1), p.80-90 |
| issn | 1053-8119 1095-9572 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73318402 |
| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Adult Amygdala - pathology Anxiety Atrophy Female Hippocampus - pathology Humans Magnetic Resonance Imaging Male NMR Nuclear magnetic resonance Panic attacks Panic Disorder - diagnosis Schizophrenia Temporal Lobe - pathology |
| title | Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T04%3A42%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Amygdalar%20atrophy%20in%20panic%20disorder%20patients%20detected%20by%20volumetric%20magnetic%20resonance%20imaging&rft.jtitle=NeuroImage%20(Orlando,%20Fla.)&rft.au=Massana,%20Guillem&rft.date=2003-05-01&rft.volume=19&rft.issue=1&rft.spage=80&rft.epage=90&rft.pages=80-90&rft.issn=1053-8119&rft.eissn=1095-9572&rft_id=info:doi/10.1016/S1053-8119(03)00036-3&rft_dat=%3Cproquest_cross%3E3244193911%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1506598989&rft_id=info:pmid/12781728&rft_els_id=S1053811903000363&rfr_iscdi=true |